Article
Oncology
Gai Zhang, Haijian Zheng, Ling Wang
Summary: The present study identified miR-491-3p as a tumor suppressor in non-small cell lung cancer (NSCLC) by directly targeting fibroblast growth factor 5 (FGF5).
Article
Biotechnology & Applied Microbiology
Yunfei Wang, Xiaobo Li, Huaqi Wang, Guojun Zhang
Summary: This study reveals a novel mechanism involving circCAMSAP1/miR-1182/BIRC5 axis that promotes the progression of non-small cell lung cancer (NSCLC).
Article
Chemistry, Medicinal
Clement Veys, Manon Jammes, Francoise Redini, Laurent Poulain, Christophe Denoyelle, Florence Legendre, Philippe Galera
Summary: This study identifies the tumor-suppressive activity of miR-342-5p and miR-491-5p in osteosarcoma cells. Both miRNAs induce apoptosis and target different proteins, offering potential for therapeutic intervention in osteosarcomas.
Article
Oncology
Hongyu Wu, Yangbao Tao, Weiyuan Zhang, Guiyu Wang, Qian Zhang
Summary: The study showed that hsa_circ_0000212 acts as a sponge for miR-491, modulating CRC cell proliferation by targeting FOXP4. Decreased miR-491 expression or increased FOXP4 expression was associated with CRC patient pathological staging. Additionally, circ-0000212 was upregulated in CRC tissues and promoted CRC cell viability by sponging miR-491 and modulating FOXP4.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, Research & Experimental
Qi Li, Xiaoxia Liu, Weifang Liu, Yang Zhang, Mengying Wu, Zhirui Chen, Yin Zhao, Li Zou
Summary: In early-onset preeclampsia (EOPE), decreased expression of MALAT1 and PFKFB3 is associated with endothelial cell dysfunction. PFKFB3 modulates the proliferation, migration, and tube formation of ECs by regulating glycolysis, while MALAT1 regulates PFKFB3 expression by sponging miR-26a/26b. MALAT1 knockdown reduces EC angiogenesis by inhibiting PFKFB3-mediated glycolysis flux, suggesting that strategies targeting PFKFB3-driven glycolysis may be a promising approach for EOPE treatment.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Reproductive Biology
Shijie Lyu, Yaying Zhai, Xiaoting Zhu, Qiaoting Shi, Fuying Chen, Geyang Zhang, Zijing Zhang, Eryao Wang
Summary: Embryonic mortality is a major factor contributing to reduced conception rates in the cattle industry. Insufficient endometrial receptivity is a key factor causing embryo implantation failure and losses. The study found that bta-miR-200b can influence the apoptosis of bovine endometrial epithelial cells by targeting the MYB gene.
Review
Biochemistry & Molecular Biology
Ruifang Sun, Zhigang Liu, Yun Lv, Yanqi Yang, Yu Xiang, Qiuyu Jiang, Changan Zhao, Moqi Lv, Jian Zhang, Juan Zhang, Caixia Ding, Dangxia Zhou
Summary: This study found that FOCAD acts as a tumor suppressor in gastric cancer and its high expression level may serve as a better prognostic marker. Additionally, FOCAD and miR-491-5p may be negatively regulated by EGR1.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2022)
Article
Hematology
Fengjie Liu, Yumei Gao, Bufang Xu, Shan Xiong, Shengguo Yi, Jingru Sun, Zhuojing Chen, Xiangjun Liu, Yingyi Li, Yuchieh Lin, Yujie Wen, Yao Qin, Shuxia Yang, Hang Li, Trilokraj Tejasvi, Lam Tsoi, Ping Tu, Xianwen Ren, Yang Wang
Summary: This study identified unique transcriptional programs and enriched expression of genes at the chr7q locus in tumors undergoing large-cell transformation (LCT) in late-stage mycosis fungoides (MF). Aberrant expression of the imprinted gene Paternally Expressed Gene 10 (PEG10) in LCT was shown to drive cell size increase, promote proliferation, and confer treatment resistance through a PEG10/KLF2/NF-kappa B axis. Pharmacological targeting of PEG10 reversed the proliferation and treatment resistance phenotypes in LCT, suggesting PEG10 inhibition as a promising therapeutic approach.
Article
Medicine, Research & Experimental
Lei Wang, Yan Liu, Zhengtao Yu, Jianwu Gong, Zhiyong Deng, Nianjun Ren, Zhe Zhong, Hao Cai, Zhi Tang, Haofeng Cheng, Shuai Chen, Zhengwen He
Summary: The study investigates the pathogenesis and potential molecular markers of glioma by examining the differential expression of miRNA and mRNA. Several miRNAs and mRNAs were identified as having significant impact on glioma cell behavior, with miR-139-5p/GABRA1 axis suggested as a novel therapeutic target.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Yan Su, Jiani Xu, Rufei Gao, Xiaoli Liu, Taihang Liu, Cong Li, Yubin Ding, Xuemei Chen, Junlin He, Xueqing Liu, Chunli Li, Hongbo Qi, Yingxiong Wang
Summary: In this study, we found that circ-CYP24A1 plays a role in RM by impairing the balance of cell proliferation and apoptosis by sponging miR-224, thereby regulating PRLR.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Fatemeh Dodangeh, Zahra Sadeghi, Parichehr Maleki, Jamshid Raheb
Summary: This study demonstrates that long non-coding RNA SOX2 overlapping transcript (SOX2-OT) plays an oncogenic role in lung cancer by regulating the miR-122-3p/FOXO1 and miR-194-5p/FOXA1 pathways, affecting the biological behaviors of lung cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ge Yang, Mei Li, Qiwen Yang, Xiangqin Zhai, Jafari Halima, Qiaoyan Hu, Chuzhao Lei, Ruihua Dang
Summary: This study reveals that bta-miR-127 inhibits proliferation and promotes apoptosis of bovine Sertoli cells (SC) by downregulating ITGA6, which has implications for male fecundity and reproductive potential.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Anatomy & Morphology
Youwen Xu, Ling Lin, Dongqing Lv, Shuangquan Yan, Susu He, Hongfei Ge
Summary: LINC01089 inhibits the proliferation of lung adenocarcinoma cells and promotes apoptosis by regulating miR-543, which is beneficial to the overall survival of LUAD patients.
Article
Cell Biology
Mengling Ye, Lu Zhao, Lu Zhang, Siyi Wu, Zhao Li, Yi Qin, Fei Lin, Linghui Pan
Summary: Colorectal cancer is a common tumor worldwide, and long non-coding RNAs play important roles in its development. This study reveals that NALT1 promotes the proliferation and migration of colorectal cancer cells by competitively regulating the expression of miRNA-574-5p and PEG10. These findings suggest the potential of NALT1 as a biomarker and therapeutic target for colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Food Science & Technology
Fei Yu, Cong Chen, Shuna Chen, Kaixi Wang, Haitao Huang, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: During the processing of black tea, the content of organic acids shows different trends in withering and rolling stages, which are regulated by various enzymes. This study provides insights into the dynamic changes and regulatory mechanisms of organic acids in black tea production.
Article
Biochemistry & Molecular Biology
Kaixi Wang, Jiafan Wu, Shuna Chen, Hangye Zhao, Puming He, Youying Tu, Bo Li
Summary: Theaflavins (TFs), characteristic components of black tea, have potential anti-diabetic activity by improving pancreatic function, intestinal tight junctions, and mitochondrial biogenesis.
Article
Food Science & Technology
Hyunuk Kang, Hui Zhou, Yushan Ye, Jiangfan Yang, Zhonghua Liu, Puming He, Bo Li, Yuanyuan Wu, Yaomin Wang, Youying Tu
Summary: Tieguanyin tea extracts have positive effects on the cognitive ability and neuroprotection of APP/PS1 mice by alleviating inflammation and improving antioxidant capacity.
Article
Biochemistry & Molecular Biology
Cong Chen, Huanqing Zhu, Jiaxin Kang, Hasitha Kalhari Warusawitharana, Shuna Chen, Kaixi Wang, Fei Yu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: This study provides a comprehensive understanding of saponin biosynthesis and accumulation in tea plants, identifying key enzymes and transcription factors involved in saponin biosynthesis through analysis of tea flower and seed samples. The mevalonate pathway, along with HMGS, MVD, IDI enzymes, were found to be responsible for saponin accumulation, highlighting the potential regulatory role of ten transcription factors in tea plant saponin biosynthesis.
Article
Biochemistry & Molecular Biology
Youying Tu, Hyunuk Kang, Eunhye Kim, Jiangfan Yang, Puming He, Yuanyuan Wu, Bo Li, Xiaobo Liu, Junsheng Liu
Summary: The study found that Tieguanyin tea extracts could alter fecal metabolites in AD mice, with Tgy-C being the most effective. Metabolomics analysis showed Tgy-C's reduction effect on fecal metabolites in AD mice, which may involve pathways like protein digestion and absorption, and amino acid biosynthesis.
Article
Environmental Sciences
Ang Li, Bo Li, Bin Lu, Dong Yang, Suxia Hou, Xiaolong Song
Summary: The generation estimation of retired mobile phones in China is calculated based on sales data and subscriber numbers. The study also analyzes the mass and material characteristics of retired mobile phones, and proposes policy implications for improving the sustainable management system.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Cong Chen, Fei Yu, Xinli Wen, Shuna Chen, Kaixi Wang, Feiquan Wang, Jianming Zhang, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: This study reveals the formation and mechanisms of (E)-2-hexenal during tea processing, and identifies the role of CsHI in this process. Additionally, it shows that abiotic stresses can regulate the proportions of (Z)-3-hexenal and (E)-2-hexenal in torn tea leaves by modulating CsHI expression levels. The findings of this study are important for the development of tea flavor and plant defense against abiotic stresses.
Editorial Material
Ecology
Ming Nie, Wenwen Liu, Steven C. Pennings, Bo Li
Article
Nutrition & Dietetics
Huanqing Zhu, Kaixi Wang, Shuna Chen, Jiaxin Kang, Na Guo, Hongbo Chen, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: Tea seed saponins can stimulate GIP expression via SGLT1 and TGR5, and have potential effects on improving metabolism and related diseases.
Review
Biochemistry & Molecular Biology
Shuna Chen, Jiaxin Kang, Huanqing Zhu, Kaixi Wang, Ziyi Han, Leyu Wang, Junsheng Liu, Yuanyuan Wu, Puming He, Youying Tu, Bo Li
Summary: L-theanine is the main amino acid in tea leaves and has both flavor and health benefits. Its immunomodulatory effects, particularly on reducing immunosuppression and improving immunity, have been studied in clinical and epidemiological research. Numerous studies on cells and animals have also shown that theanine plays a role in regulating inflammation, nerve damage, the intestinal tract, and tumors by regulating certain cellular functions.
Review
Biochemistry & Molecular Biology
Hongbo Chen, Fei Yu, Jiaxin Kang, Qiao Li, Hasitha Kalhari Warusawitharana, Bo Li
Summary: The composition and contents of organic acids vary in different types of tea. They play important roles in the metabolism of tea plants, nutrient absorption and growth regulation, as well as the aroma and taste quality of tea. However, the research on organic acids in tea is still limited. This article reviewed the progress made in studying organic acids in tea, including analysis methods, physiological functions, composition and influencing factors, sensory contributions, as well as health benefits like antioxidation and digestion promotion. It aims to provide references for further research on organic acids in tea.
Article
Plant Sciences
Yuanfei Pan, Mu Liu, Alejandro Sosa, Bo Li, Mang Shi, Xiaoyun Pan
Summary: This study investigates the metacommunities of endophytic fungi in the leaves of an invasive plant and finds that the structure of these fungal communities is influenced by multiple spatial scales and different drivers. These findings are important for understanding the global patterns of fungal diversity.
Article
Computer Science, Interdisciplinary Applications
Xian Song, Bo Li, Pengyu Wang, Yizhao Zhou, Jian Wang, Yaqun Wang, Chengbing Fang, Meiyuan Jin
Summary: This article fabricated a flexible piezoelectric sensor to gather data for the pulse-taking procedure and used it to recognize whether a woman is pregnant. The pulse signal was processed by GoogleNet and achieved a 90.48% correction rate, which solidified the objectivity of pulse diagnosis and raised the digitalization level of TCM.
ENGINEERING REPORTS
(2023)
Article
Remote Sensing
Xi Zhang, Xiangming Xiao, Xinxin Wang, Xiao Xu, Shiyun Qiu, Lianghao Pan, Jun Ma, Ruiting Ju, Jihua Wu, Bo Li
Summary: Biological invasions, especially by Spartina alterniflora, are significantly impacting the structure and functions of coastal ecosystems in China. Urgent efforts to control the spread of this invasive species are hindered by the lack of time-series data. By using satellite images, this study successfully generated annual maps of Spartina saltmarshes from 1985 to 2020, revealing a continuous expansion of Spartina along the coast. The invasion history and frequency of changes were found to be influenced by latitude, with low latitudes experiencing longer and more frequent invasions. Human interventions have contributed to the decline in certain areas, but natural spread remains the primary driver of its extensive invasion.
INTERNATIONAL JOURNAL OF APPLIED EARTH OBSERVATION AND GEOINFORMATION
(2023)
Article
Instruments & Instrumentation
W. Liu, Z. Zhang, J. Wu, T. Ma, Y. Zhang, Y. M. Hu, Y. Q. Zhang, Y. Y. Huang, H. X. Jiang, X. K. Jiang, D. Y. Chen
Summary: This article focuses on the pre-launch characterization of the HXI spectrometer, including detection efficiency, energy resolution, and energy to ADC channel relationship. The characterization results show that the HXI spectrometer meets the performance requirements and is capable of performing on-orbit observation activities.
JOURNAL OF INSTRUMENTATION
(2022)
