Article
Nutrition & Dietetics
Silvia D. Stan, Minna Abtahi
Summary: This study demonstrates that DATS inhibits cell proliferation and induces apoptosis in breast DCIS and minimally invasive breast cancer cells.
Article
Biochemistry & Molecular Biology
Su-Hyeong Kim, Shivendra Singh
Summary: This study reveals that MCT1 is a novel target for bCSC inhibition by DATS treatment. The findings show that DATS can suppress MCT1 protein expression and decrease lactate levels in breast cancer cells. Additionally, the expression level of MCT1 is associated with the inhibition of bCSCs.
MOLECULAR CARCINOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Miaomiao Ge, Jianyun Zhu, Kefan Yi, Yue Chen, Wanshuang Cao, Menghuan Wang, Chunfeng Xie, Xiaoting Li, Shanshan Geng, Jieshu Wu, Caiyun Zhong, Hui Cao, Zhiwei Jiang, Hongyu Han
Summary: Gastric cancer is a deadly malignant tumor often characterized by recurrences or metastasis even after eradication therapy. Cancer stem cells (CSCs) play a crucial role in this process, and the sonic hedgehog (SHH) pathway is important in maintaining CSC characteristics. The role of p63 proteins in regulating CSCs is not well understood. Dietary diallyl trisulfide (DATS) has been shown to have preventive effects against gastric cancer, but its effect on targeting gastric CSCs is poorly understood. This study investigates the role of ?Np63/SHH pathway in gastric CSCs and the inhibitory effect of DATS on gastric CSCs.
MOLECULAR CARCINOGENESIS
(2023)
Article
Plant Sciences
Rakshmitha Marni, Durga Bhavani Kundrapu, Anindita Chakraborti, RamaRao Malla
Summary: DADS and DATS from garlic could be potential sensitizers for drug-resistant breast cancers by inhibiting cell proliferation via cell cycle arrest and inducing apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
RamaRao Malla, Rakshmitha Marni, Anindita Chakraborty, Mohammad Amjad Kamal
Summary: Breast cancer is a major cause of cancer-related deaths in women worldwide. The increase in tumor heterogeneity and aggressiveness has made the treatment of breast cancer challenging. High intake of certain Allium vegetables, such as garlic, has been associated with a reduced risk of developing breast cancer. DADS and DATS, compounds found in garlic, have anticancer activity and can interfere with breast cancer cell proliferation and metastasis. This review focuses on multidrug resistance mechanisms in breast cancer and discusses the potential anticancer activities of DADS and DATS, particularly in triple-negative breast cancer.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Engineering, Biomedical
Yani Cui, Mingda Zhao, Yuedi Yang, Ruiling Xu, Lei Tong, Jie Liang, Xingdong Zhang, Yong Sun, Yujiang Fan
Summary: A promising combined chemotherapeutic strategy using a targeted co-delivery nanosystem has been developed to overcome abnormal progression in drug-resistant tumor cells and cancer stem cells. The strategy effectively inhibits the Wnt/β-catenin signaling pathway and EMT process, leading to a reduction in tumor growth and metastasis risk.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Bo Wei, Jia Cao, Jin-Hai Tian, Chuan-Yang Yu, Qi Huang, Jing-Jing Yu, Rong Ma, Jia Wang, Fang Xu, Li-Bin Wang
Summary: Research findings suggest that overexpression of mortalin in breast cancer is associated with poorer overall survival rates, with its activation of the Wnt/GSK3β/β-catenin signaling pathway promoting Epithelial-mesenchymal transition (EMT) and maintaining the stemness of breast cancer stem cells (BCSCs).
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Ben Yang, Fengling Wang, Gang Zheng
Summary: This study investigated the role of TMEM119 in breast cancer progression and found that TMEM119 overexpression is associated with poor survival in patients. Knockdown of TMEM119 reduced stemness marker expression. RNA-sequencing and Co-IP experiments confirmed the relationship between TMEM119 and Wnt/beta-catenin signaling pathway.
Article
Pathology
Ziwei Zhao, Xue Han, Chen Nie, Shan Lin, Jingwei Wang, Hong Fang
Summary: This study used bioinformatics to identify differentially expressed circular RNAs (circRNAs) in triple-negative breast cancer tissues. The circ_0008784 was found to promote proliferation and inhibit apoptosis of TNBC cells, while miR-506-3p was found to suppress proliferation and facilitate apoptosis. Additionally, circ_0008784 was shown to regulate the Wnt/beta-catenin signaling pathway and modulate the progression of TNBC cells through sponging miR-506-3p to modulate catenin beta 1 (CTNNB1).
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Yun Wang, Qian Liang, Kefeng Lei, Qingqing Zhu, Delong Zeng, Yuhong Liu, Yingsi Lu, Tingting Kang, Nannan Tang, Lifen Huang, Liping Ye, Di Tang, Chengming Zhu
Summary: MEX3A expression is significantly upregulated in breast cancer, related to tumor grade, and plays a critical role in promoting metastasis and maintaining stemness through the Wnt/beta-catenin pathway.
Article
Pharmacology & Pharmacy
Hua Wang, Yinfeng Tan, Hao Jia, Danqi Liu, Rangru Liu
Summary: In this study, it was found that Posaconazole (POS) has potential antitumor activity against glioblastoma (GBM) and its molecular mechanisms were elucidated. POS can weaken the stemness of CSCs and promote autophagy induction. It was also revealed that POS targets survivin and suppresses the Wnt/β-catenin signaling pathway in GBM. This study provides an experimental foundation for the development of POS as a CSCs-targeting antitumor drug for GBM treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Oncology
Baohong Jiang, Hongbo Zhu, Liting Tang, Ting Gao, Yu Zhou, Fuqiang Gong, Yeru Tan, Liming Xie, Xiaoping Wu, Yuehua Li
Summary: In this study, the researchers investigated the effects of Apatinib and lncRNA ROR on breast cancer stem cells (BCSCs) and found that Apatinib could inhibit the stemness and malignant behaviors of BCSCs by down-regulating lncRNA ROR and blocking the Wnt/β-catenin signal pathway.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Hui Liu, Xinxin Zhang, Can Fang, Shuguang Li
Summary: This study aimed to determine the expression levels of RUNX3 and CDX2 in patients with chronic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer. CDX2 overexpression or Res treatment inhibited cell proliferation, migration, and invasion, while inducing cell apoptosis. Our results indicate that Res inhibits the growth of MKN7 and TMK1 cells by increasing RUNX3 and CDX2 expression levels, with the potential involvement of the beta-catenin/TCF-4 signaling pathway.
TRANSLATIONAL ONCOLOGY
(2023)