期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 8, 页码 3758-3767出版社
WILEY
DOI: 10.1111/jcmm.13633
关键词
hepatocellular carcinoma; HOXA11-AS; LncRNA; miR-214-3p
资金
- National Natural Science Foundation of China [81641110, 81571785, 81771957]
- Science and Technology Foundation of Guangdong Province, China [2013B021800180]
- Natural Science Foundation of Guangdong Province, China [2015A030313725, 2016A030311055, 2016A030313770]
- Science and Technology Program of Guangzhou Province, China [201707010305]
- Youth Science Fund of Guangdong Second Provincial General Hospital [YQ2006-001]
Accumulating studies supported that lncRNAs played important roles in tumorigenesis. LncRNA HOXA11-AS was a novel lncRNA that has been proved to involved in several tumours. However, the role of HOXA11-AS in the development of hepatocellular carcinoma (HCC) remains to be explained. In our study, we showed that HOXA11-AS expression was up-regulated in the HCC tissues, and the higher expression of HOXA11-AS was associated with the advanced stage in the HCC samples. In addition, we indicated that the expression of HOXA11-AS was up-regulated in HCC cell lines (Hep3B, SMMC-7721, MHCC97-H and BEL-7402) compared with normal liver cell lines (HL-7702). Overexpression of HOXA11-AS promoted HCC proliferation and invasion and induced the epithelial-mesenchymal transition (EMT) and knockdown of HOXA11-AS suppressed the HCC cell proliferation and invasion. However, we showed that miR-214-3p expression was down-regulated in the HCC tissues and cell lines. Ectopic expression of miR-214-3p suppressed HCC cell proliferation and invasion. Furthermore, we indicated that overexpression of HOXA11-AS decreased the miR-214-3p expression and the expression of miR-214-3p was negatively related with the HOXA11-AS expression in HCC samples. Ectopic expression of HOXA11-AS increased HCC proliferation and invasion and induced EMT through inhibiting miR-214-3p expression. These data suggested that HOXA11-AS/miR-214-3p axis was responsible for development of HCC.
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