Nrf2 attenuates inflammatory response in COPD/emphysema: Crosstalk with Wnt3a/β-catenin and AMPK pathways

Maintenance therapy in COPD: time to phase out ICS and switch to the new LAMA/LABA inhalers?

(2017) Syed Mohammad Tariq et al.   International Journal of Chronic Obstructive Pulmonary Disease

Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases

(2016) Li Yue et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of a Mouse Model of Emphysema Induced by Multiple Instillations of Low-Dose Elastase

(2016) Milena V. Oliveira et al.   Frontiers in Physiology

Regulation of AMP-activated protein kinase by natural and synthetic activators

(2016) David Grahame Hardie   Acta Pharmaceutica Sinica B

Cigarette Smoke–Induced Damage-Associated Molecular Pattern Release from Necrotic Neutrophils Triggers Proinflammatory Mediator Release

(2015) Irene H. Heijink et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

WNT-3A Regulates an Axin1/NRF2 Complex That Regulates Antioxidant Metabolism in Hepatocytes

(2015) Patricia Rada et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition

(2015) Wenhui Cui et al.   INFLAMMATION RESEARCH

Regulation of Cigarette Smoke Induction of IL-8 in Macrophages by AMP-activated Protein Kinase Signaling

(2015) Hsin-Kuo Ko et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt3a Mediates the Inhibitory Effect of Hyperoxia on the Transdifferentiation of AECIIs to AECIs

(2015) Wei Xu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Distinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock

(2015) Hiong-Ping Hii et al.   PLoS One

Activation of Wnt/β-catenin signalling promotes mesenchymal stem cells to repair injured alveolar epithelium induced by lipopolysaccharide in mice

(2015) Shi-xia Cai et al.   Stem Cell Research & Therapy

GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury

(2014) Dae Won Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

WNT/β-Catenin Signaling Induces IL-1β Expression by Alveolar Epithelial Cells in Pulmonary Fibrosis

(2013) Verena Aumiller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

AMP-activated Protein Kinase Regulates β-Catenin Transcription via Histone Deacetylase 5

(2011) Jun-Xing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

(2011) Hongwei Yao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of the WNT/β-Catenin Pathway Attenuates Experimental Emphysema

(2010) Nikolaus Kneidinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of β-catenin at Ser 552

(2010) Junxing Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice

(2008) Hongwei Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

(2008) Nanao Horike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

(2008) Melanie Königshoff et al.   PLoS One

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA