Article
Biochemistry & Molecular Biology
Zhiyang Zhou, Li Jin, Jian Shen, Weihui Shi, Yue Xu, Longyun Ye, Junxi Liu, Jiexue Pan
Summary: A novel synthetic agent, COM33, is developed to relieve chemoresistance caused by carboplatin in ovarian cancer. The combination of COM33 and carboplatin enhances the inhibitory effects on cancer cells and suppresses tumor growth. COM33 also inhibits carboplatin-induced epithelial-mesenchymal transition by inhibiting the ERK signaling pathway.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Jihye Seo, Jain Ha, Eunjeong Kang, Haelim Yoon, Sewoong Lee, Shi Yong Ryu, Kwonseop Kim, Sayeon Cho
Summary: Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major cause of cancer-related deaths worldwide. Glaucarubinone (GCB) has been identified as having the potential to inhibit cancer cell migration and exhibit anti-cancer effects by regulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiaobin Yu, Tao He, Zhangwei Tong, Lan Liao, Shixia Huang, Walid D. Fakhouri, Dean P. Edwards, Jianming Xu
Summary: TWIST1 plays a role in inducing EMT and cancer metastasis through its interactions with NuRD and TIP60-Com complexes. Non-acetylated TWIST1-K73/76 interacts with NuRD to repress epithelial target gene transcription, while diacetylated TWIST1-acK73/76 interacts with TIP60-Com to activate mesenchymal target genes and MYC. BRD8 is essential for the interaction between TWIST1-acK73/76 and TIP60-Com, and targeting BRD8 could be a potential strategy to inhibit TWIST1-activated gene expression.
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xin Zhao, Xiaoshi Zhang, Xinxue Zhang, Tao Jiang, Jialei Zhai, Huaguang Wang, Mengxiu Huang, Ren Lang, Qiang He
Summary: This study revealed that miR-374b-5p is downregulated in pancreatic cancer (PC) and its overexpression can inhibit the proliferation, migration, and invasion of PC cells by suppressing the expression of KDM5B, thereby reducing epithelial-mesenchymal transition (EMT) in PC. The findings suggest that miR-374b-5p could potentially serve as a prognostic biomarker and therapeutic target for EMT induced by KDM5B in PC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan
Summary: This study reveals the crucial role of TWIST1 in the establishment of a cancer stem cell-like phenotype, EMT progression, and inhibition of apoptosis in esophageal squamous cell carcinoma (ESCC). These findings provide evidence for TWIST1 as a therapeutic target for suppressing CSC generation and ESCC malignancy.
Article
Medicine, Research & Experimental
Yunhui Zhou, Xinyi Zhou, Qiwen Ben, Ningning Liu, Jiahui Wang, Yongpeng Zhai, Yichen Bao, Lin Zhou
Summary: PDAC is characterized by a hypoxic microenvironment, high heterogeneity, and high recurrence rate. This study found that GATA6-AS1 expression is significantly decreased in PDAC and low expression is associated with unfavorable clinicopathologic characteristics and poor prognosis. Functional studies showed that GATA6-AS1 can suppress the proliferation, invasion, migration, and EMT process of PDAC cells under hypoxia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Surgery
Sho Fujiwara, Yuriko Saiki, Shinichi Fukushige, Mie Yamanaka, Masaharu Ishida, Fuyuhiko Motoi, Michiaki Unno, Akira Horii
Summary: TWIST1 is an important poor prognostic factor for pancreatic ductal adenocarcinoma (PDAC) patients who undergo adjuvant chemotherapy after radical resection. Positive expression of TWIST1 is associated with significantly poorer prognosis in terms of relapse-free survival and overall survival. This finding suggests that TWIST1 can be utilized as a predictive factor for the response to adjuvant chemotherapies in PDAC patients.
Article
Biotechnology & Applied Microbiology
Zhenglei Xu, Zeming Chen, Minsi Peng, Zhuliang Zhang, Weixiang Luo, Ruiyue Shi, Lisheng Wang, Yingcai Hong
Summary: Pancreatic cancer is difficult to treat, and the main reasons for poor prognosis are cell invasion and migration. In this study, researchers found that miR-490-5p is abnormally low-expressed in pancreatic cancer and downregulation of miR-490-5p enhances the viability, migration, and invasion of pancreatic cancer cells. Additionally, miR-490-5p regulates the protein expression of MMP2, MMP9, and N-cadherin, and upregulates the protein expression of E-cadherin. The expression of MAGI2-AS3 is also associated with cell viability, migration, and invasion in pancreatic cancer. The study reveals that miR-490-5p plays an anti-cancer role in pancreatic cancer by targeting MAGI2-AS3 and regulating EMT.
Review
Biochemistry & Molecular Biology
Ying Xu, Qing Zhu
Summary: Pancreatic cancer is a lethal disease characterized by high invasiveness, early metastasis, rapid progression, and late diagnosis. The ability of pancreatic cancer cells to undergo EMT plays a crucial role in their tumorigenic and metastatic potential, as well as therapeutic resistance. Histone modifications, a central epigenetic modification, are closely involved in EMT. In this review, we discuss the mechanisms by which histone-modifying enzymes regulate EMT in pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hui-Jing Xu, Jing Bai, Ye Tian, Xiao Feng, Ai-Ping Chen, Jie Wang, Jin Wu, Xu-Ru Jin, Feng Zhang, Mei-Yu Quan, Chengshui Chen, Kwang-youl Lee, Jin-San Zhang
Summary: The epithelium-specific ETS transcription factor 1 (ESE1) has been found to be upregulated in primary pancreatic ductal adenocarcinoma (PDAC). Interestingly, high expression of ESE1 is associated with better relapse-free survival in PDAC patients. ESE1 exhibits dual roles in regulating malignant properties of PDAC cells by promoting cell proliferation when overexpressed and enhancing epithelial-mesenchymal transition (EMT) phenotype when downregulated. ESE1 interacts with TGF-beta signaling to modulate EMT phenotype in PDAC.
Article
Cell Biology
Julienne L. Carstens, Sujuan Yang, Pedro Correa de Sampaio, Xiaofeng Zheng, Souptik Barua, Kathleen M. McAndrews, Arvind Rao, Jared K. Burks, Andrew D. Rhim, Raghu Kalluri
Summary: The study indicates that partial epithelial to mesenchymal transition is associated with metastasis in pancreatic ductal adenocarcinoma (PDAC), and genetic suppression can lead to epithelial stabilization and increased liver metastasis.
Article
Pharmacology & Pharmacy
Ting Li, Tianyi Ren, Chumei Huang, Yufang Li, Pengfei Yang, Gang Che, Lisi Luo, Yutong Chen, Siqi Peng, Yujing Lin, Linjuan Zeng
Summary: PDAC is a lethal cancer with poor survival rates due to poor treatment response. The study identified S100A16 as a potential therapeutic target for PDAC treatment, showing its correlation with poor prognosis and role in promoting cancer cell metastasis through EMT and TWIST1/STAT3 signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao, Wei Wang
Summary: The research revealed that FZD5 prevents EMT in gastric cancer and is associated with longer survival. ELF3 acts as a downstream effector of FZD5, repressing ZEB1 expression and guarding against EMT.
CELL COMMUNICATION AND SIGNALING
(2021)