Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes

Amyloid-β Secretion, Generation, and Lysosomal Sequestration in Response to Proteasome Inhibition: Involvement of Autophagy

(2018) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Stage-Dependent Axon Transport of Proteasomes Contributes to Axon Development

(2015) Meng-Tsung Hsu et al.   DEVELOPMENTAL CELL

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway

(2015) Utpal Das et al.   NATURE NEUROSCIENCE

Golgi defects enhance APP amyloidogenic processing in Alzheimer's disease

(2014) Gunjan Joshi et al.   BIOESSAYS

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function

(2014) M. G. Otero et al.   JOURNAL OF CELL SCIENCE

UV Irradiation Accelerates Amyloid Precursor Protein (APP) Processing and Disrupts APP Axonal Transport

(2014) A. Almenar-Queralt et al.   JOURNAL OF NEUROSCIENCE

A Proteolytic Cascade Controls Lysosome Rupture and Necrotic Cell Death Mediated by Lysosome-Destabilizing Adjuvants

(2014) Jürgen Brojatsch et al.   PLoS One

Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production

(2014) Gunjan Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition

(2013) Valentina Cecarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Proteasome Function Reporter GFPu Accumulates in Young Brains of the APPswe/PS1dE9 Alzheimer’s Disease Mouse Model

(2013) Yanying Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Proteasome inhibition induces stress kinase dependent transport deficits — Implications for Alzheimer's disease

(2013) Lotta Agholme et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

The Drosophila Homologue of the Amyloid Precursor Protein Is a Conserved Modulator of Wnt PCP Signaling

(2013) Alessia Soldano et al.   PLOS BIOLOGY

Fluorescence correlation spectroscopy

(2012) Jonas Ries et al.   BIOESSAYS

Enhanced  -secretase processing alters APP axonal transport and leads to axonal defects

(2012) E. M. Rodrigues et al.   HUMAN MOLECULAR GENETICS

Amyloid precursor protein accumulates in aggresomes in response to proteasome inhibitor

(2012) Nodi Dehvari et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal transport and neurodegenerative disease: Can we see the elephant?

(2012) Lawrence S.B. Goldstein   PROGRESS IN NEUROBIOLOGY

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

(2012) M. Steuble et al.   Biology Open

Nonproteasomal Targets of the Proteasome Inhibitors Bortezomib and Carfilzomib: a Link to Clinical Adverse Events

(2011) S. Arastu-Kapur et al.   CLINICAL CANCER RESEARCH

Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of  -Synuclein

(2011) D. Ebrahimi-Fakhari et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteasomal inhibition alters the trafficking of the neurotrophin receptor TrkA

(2009) T. Moises et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of the Proteasome by Neuronal Activity and Calcium/Calmodulin-dependent Protein Kinase II

(2009) Stevan N. Djakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cleavage Products of Amyloid-  Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites

(2009) V. Muresan et al.   JOURNAL OF NEUROSCIENCE

Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects

(2009) T. L. Falzone et al.   JOURNAL OF NEUROSCIENCE

Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

(2009) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

APP Anterograde Transport Requires Rab3A GTPase Activity for Assembly of the Transport Vesicle

(2009) A. Szodorai et al.   JOURNAL OF NEUROSCIENCE

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin

(2008) David F. Fischer et al.   NEUROBIOLOGY OF AGING

TrkA Receptor Endolysosomal Degradation is Both Ubiquitin and Proteasome Dependent

(2008) Thangiah Geetha et al.   TRAFFIC