Article
Nutrition & Dietetics
Rebeca Quiros-Fernandez, Bricia Lopez-Plaza, Laura M. Bermejo, Samara Palma Milla, Andrea Zangara, Carmen Gomez Candela
Summary: The supplement containing HT and PC showed significant improvement in dyslipidemia, indicating its potential for preventing atherosclerosis and protecting the heart in adults.
Review
Environmental Sciences
Soon Hoe Ho, Stacy Xin Hui Soh, Min Xian Wang, Janet Ong, Annabel Seah, Yvonne Wong, Zhanxiong Fang, Shuzhen Sim, Jue Tao Lim
Summary: This systematic review examines the associations between perfluoroalkyl substances (PFAS) and lipid concentrations in human populations. The results suggest that PFAS exposure is associated with higher levels of LDL, HDL, and TC, while the association with TG tends to be negative. Additionally, the study indicates a positive relationship between PFAS concentrations and cholesterol-related health outcomes. Further research is needed to investigate the effects of less-studied PFAS on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Hiroko Inoue, Yuhei Shiga, Kenji Norimatsu, Kohei Tashiro, Makito Futami, Yasunori Suematsu, Makoto Sugihara, Hiroaki Nishikawa, Yousuke Katsuda, Shin-ichiro Miura
Summary: The study found that in addition to HDL-C, total CEC was associated with the presence of MACE, while %CEC and HDL functionality were not associated with MACE.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Lu Xu, Kai Wang, Shengfeng Wang, Lili Liu, Xiaozhen Lv, Yongfeng Song
Summary: This study revealed that high levels of triglycerides increased the risk of depressive symptoms in men, especially in individuals without hypertension and diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Guizhi Deng, Yunjie Li, Wenke Cheng
Summary: The study aimed to investigate the relationship between lipid profile and prevalence of hypertension in Chinese adult women. The results showed that TC, LDL-c, and non-HDL-c were positively associated with hypertension prevalence, while HDL-c was negatively associated with hypertension prevalence but became nonsignificant after full adjustment for variables.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael Georgoulis, Christina Chrysohoou, Ekavi Georgousopoulou, Evangelia Damigou, Ioannis Skoumas, Christos Pitsavos, Demosthenes Panagiotakos
Summary: This study found that the impact of blood lipids on CVD risk varies according to several biological, lifestyle, and clinical parameters. TC and LDL-C were significant predictors of CVD risk in younger, normal-weight individuals not on lipid-lowering drugs. HDL-C and TG were significant predictors in older individuals, those with low adherence to the Mediterranean diet, and individuals with hypercholesterolemia.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Cell Biology
Yukihito Higashi
Summary: Dyslipidemia is linked to endothelial dysfunction leading to atherosclerosis and cardiovascular complications. Breaking the progression from endothelial dysfunction to cardiovascular complications is clinically important in dyslipidemia patients. Lipid-lowering therapy improves endothelial function in dyslipidemia patients. The relationships of components of a lipid profile with endothelial function, such as LDL cholesterol, HDL cholesterol, and triglycerides, are complex. This review focuses on exploring their roles.
Article
Public, Environmental & Occupational Health
Siwei Chen, Wenke Cheng
Summary: The study found that elevated total cholesterol, LDL-c, and non-HDL-c were related to the incidence of hypertension in Chinese adult males. Triglycerides, however, were not significantly associated. After adjusting for BMI, the relationship between HDL-c and hypertension shifted from no association to a positive correlation. The BN model showed that age, BMI, fasting plasma glucose (FPG), and total cholesterol were strongly associated with hypertension incidence.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Agriculture, Multidisciplinary
Jiaheng Xia, Ping Yu, Zheling Zeng, Maomao Ma, Guohua Zhang, Dongman Wan, Deming Gong, Shuguang Deng, Jun Wang
Summary: The study revealed that high-dose lauric triglycerides affected cholesterol metabolism in obese rats by downregulating cholesterol biosynthesis and improving lipid transfer, but also accelerated LDL receptor degradation, impaired VLDL/LDL transport, ultimately leading to elevated levels of TC and LDL-c.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Medicine, General & Internal
Mehran Nouri, Mohammad Ali Mohsenpour, Niki Katsiki, Saeed Ghobadi, Alireza Jafari, Shiva Faghih, Maciej Banach, Mohsen Mazidi
Summary: In this meta-analysis, the relationship between serum lipid profile and breast cancer risk was investigated. The results showed a negative association between high-density lipoprotein cholesterol (HDL-C) level and breast cancer risk, while other indicators such as TG, TC, ApoA and LDL-C were not associated with breast cancer development.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Deborah de Farias Lelis, Roberto S. Cunha, Raul D. Santos, Andrei C. Sposito, Rosane Harter Griep, Sandhi Maria Barreto, Maria del Carmen B. Molina, Maria Ines Schmidt, Bruce B. Duncan, Isabela Bensenor, Paulo Andrade Lotufo, Jose Geraldo Mill, Marcelo Perim Baldo
Summary: Atherogenic dyslipidemia is associated with carotid-femoral pulse wave velocity (cf-PWV), and there is a linear association between triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and the triglycerides to high-density lipoprotein (TG/HDL-C) ratio with arterial stiffness. HDL-C has a stronger association with arterial stiffness, while the association of TG/HDL-C with arterial stiffness is dependent on HDL-C levels.
Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Multidisciplinary Sciences
C. J. MacDonald, A. L. Madika, G. Severi, A. Fournier, M. C. Boutron-Ruault
Summary: The study found that non-O blood groups, particularly the A group, are associated with an increased risk of dyslipidaemia. Current smokers have a 30% higher risk of dyslipidaemia compared to never-smokers. These results could be useful for personalized approaches to preventing cardiovascular risk factors.
SCIENTIFIC REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Yuxiong Chen, Zhen'ge Chang, Yijie Liu, Yakun Zhao, Jia Fu, Yongqiao Zhang, Yanbo Liu, Zhongjie Fan
Summary: Elevated TG/HDL-C ratio may be independently associated with an increased risk of cardiovascular events in the general population. More well-designed studies are needed to confirm the current findings.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Jamal S. Rana, Salim S. Virani, Howard H. Moffet, Jennifer Y. Liu, Landis A. Coghlan, Jitesh Vasadia, Christie M. Ballantyne, Andrew J. Karter
Summary: The study aimed to evaluate the association between outpatient LDL-C testing and subsequent statin adherence and intensification in patients after an ASCVD event. The results showed that LDL-C testing was associated with improved statin adherence and higher rates of treatment intensification.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Peiyue Zhang, Cuiyuan Huang, Haiyin Liu, Mengting Zhang, Li Liu, Yuhong Zhai, Jing Zhang, Jian Yang, Jun Yang
Summary: NFAT is a widely expressed transcriptional activator that is involved in regulating the immune system, heart and brain development, and mediating pathological processes such as cardiac hypertrophy. Oxidative stress, characterized by excessive production of reactive oxygen species, mitochondrial dysfunction, calcium overload, and subsequent lipid peroxidation, inflammation, and apoptosis, is associated with various pathological processes. Calcium overload activates NFAT through the calcium-calcineurin pathway, which is the main regulatory mode of NFAT factors. This review focuses on the effects of NFAT transcription factors on reactive oxygen species production, calcium overload, mitochondrial dysfunction, redox reactions, lipid peroxidation, inflammation, and apoptosis in response to oxidative stress. The aim is to provide a reference for understanding the functions and characteristics of NFAT in different stages of oxidative stress and related potential targets.
JOURNAL OF CARDIOLOGY
(2024)
