Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia

KDM6 and KDM4 histone lysine demethylases emerge as molecular therapeutic targets in human acute myeloid leukemia

(2018) Liberalis Debraj Boila et al.   EXPERIMENTAL HEMATOLOGY

KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

(2017) H Ohguchi et al.   LEUKEMIA

A novel LSD1 inhibitor NCD38 ameliorates MDS-related leukemia with complex karyotype by attenuating leukemia programs via activating super-enhancers

(2017) N Sugino et al.   LEUKEMIA

Inhibitor of H3K27 demethylase JMJD3/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer

(2017) Viacheslav M. Morozov et al.   Oncotarget

Abstract SY27-01: Inhibiting histone demethylases to target metabolic dependencies in multiple myeloma

(2016) Udo Oppermann   CANCER RESEARCH

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

(2016) T. Ryotokuji et al.   HAEMATOLOGICA

Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs

(2016) Rohit Mathur et al.   HAEMATOLOGICA

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

(2016) Yoshinori Ishikawa et al.   MOLECULAR CANCER THERAPEUTICS

Genomic Classification and Prognosis in Acute Myeloid Leukemia

(2016) Elli Papaemmanuil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression

(2016) Takeshi Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion

(2016) Xiaohui Si et al.   Oncotarget

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

(2016) T. Ryotokuji et al.   HAEMATOLOGICA

Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs

(2016) Rohit Mathur et al.   HAEMATOLOGICA

Aberrant Expression of HOXA5 and HOXA9 in AML

(2015) Peng Zhao et al.   Asian Pacific Journal of Cancer Prevention

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

(2015) Frederik Otzen Bagger et al.   NUCLEIC ACIDS RESEARCH

Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors

(2014) M. Bots et al.   BLOOD

Combining DNA methyltransferase and histone deacetylase inhibition to treat acute myeloid leukemia/myelodysplastic syndrome: Achievements and challenges

(2014) Michael Lübbert et al.   CANCER

Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process

(2014) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells

(2014) W Fiskus et al.   LEUKEMIA

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

(2014) Rintaro Hashizume et al.   NATURE MEDICINE

Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic

(2014) Muneera Al-Hussaini et al.   Expert Review of Hematology

Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells

(2013) Y Wei et al.   LEUKEMIA

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia

(2012) S. Tanaka et al.   BLOOD

Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway

(2012) Wei Jiang et al.   CELL RESEARCH

Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs

(2012) Ling Ye et al.   Cell Stem Cell

Bivalent histone modifications in early embryogenesis

(2012) Nadine L Vastenhouw et al.   CURRENT OPINION IN CELL BIOLOGY

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

(2011) A. T. Nguyen et al.   BLOOD

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells

(2011) E. F. de Zoeten et al.   MOLECULAR AND CELLULAR BIOLOGY

Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

(2011) Margaret E. McLaughlin-Drubin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

(2009) W. Fiskus et al.   BLOOD

PrognoScan: a new database for meta-analysis of the prognostic value of genes

(2009) Hideaki Mizuno et al.   BMC Medical Genomics

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML

(2008) K Kojima et al.   LEUKEMIA