Article
Engineering, Biomedical
Alessandra Aldieri, Pinaki Bhattacharya, Margaret Paggiosi, Richard Eastell, Alberto Luigi Audenino, Cristina Bignardi, Umberto Morbiducci, Mara Terzini
Summary: This study proposes a statistical model based on three-dimensional shape and intensity for predicting hip fracture risk in Caucasian postmenopausal women. The results show that intensity components outperform shape components in stratifying patients based on their fracture status, and the combination of intensity and shape further improves risk stratification.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Medicine, General & Internal
Mustafa Cukurlu, Bekir Karagoz, Ozan Keceli
Summary: This study aimed to analyze the relationship between fracture type in patients over 65 years of age who had hip fractures by determining data on the geometry of the proximal femur in the pre-fracture period. Measurements were performed to evaluate various geometric parameters of the proximal femur. The results showed that the geometric parameters play an important role in the formation of hip fracture types.
Article
Infectious Diseases
Dolors Rodriguez-Pardo, Laura Escola-Verge, Julia Sellares-Nadal, Pablo S. Corona, Benito Almirante, Carles Pigrau
Summary: In patients with proximal femoral fractures, there is a lack of specific guidelines for preventing periprosthetic joint infections after hip hemiarthroplasty surgery. General prophylaxis guidelines, such as the use of cefazolin, are commonly applied. Personalized antibiotic schemes may be considered for patients suspected of colonization by multidrug-resistant microorganisms.
Article
Engineering, Biomedical
Saulo Martelli, John J. Costi
Summary: This study developed a novel protocol for applying three-dimensional, time-varying hip contact force to a human femur specimen, providing repeatable load profiles for bone and implant testing. With low error in force control and linear relationships between force, position, and strain at different frequencies, the protocol can support dynamic tests of bone and implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Nutrition & Dietetics
Raffaello Pellegrino, Roberto Paganelli, Stefania Bandinelli, Antonio Cherubini, Cristina Andres-Lacueva, Angelo Di Iorio, Eleonora Sparvieri, Raul Zamora-Ros, Luigi Ferrucci
Summary: A high intake of polyphenols is associated with higher bone-mineral density, but the urinary levels of polyphenols are associated with long-term accelerated bone deterioration. This study found that higher urinary excretion and dietary intake of polyphenols were associated with an increased risk of hip fractures.
Article
Multidisciplinary Sciences
Yasuhiro Homma, Shun Ito, Xu Zhuang, Tomonori Baba, Kazutoshi Fujibayashi, Kazuo Kaneko, Yu Nishiyama, Muneaki Ishijima
Summary: Recent studies have focused on analyzing the hammering sound during the insertion of cementless stems in total hip arthroplasty to reduce complications. A preliminary feasibility study demonstrated that artificial intelligence using machine learning can accurately distinguish the final rasping hammering sound from previous sounds.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ulf Boekeler, Ulrich Liener, Nils Vogeley, Benjamin Mayer, Cornelia Horsch, Fridolin Troester, Daphne Eschbach, Steffen Ruchholtz, Tom Knauf
Summary: Patients with occult hip fractures are difficult to treat. The purpose of this study was to determine whether changes in the proximal femur geometry can predict the likelihood of an occult hip fracture. The results showed that single radiologic indices have a weak predictive value in detecting occult fractures of the hip.
MEDICINA-LITHUANIA
(2023)
Article
Engineering, Biomedical
Marco Palanca, Egon Perilli, Saulo Martelli
Summary: This study found that the risk of osteoporotic hip fractures in a sideways fall depends on both variations of body anthropometry and bone strength. The overlapping ranges of hip impact energy and fracture energy showed relatively small differences. Evaluating factors such as fracture patterns, force, and energy can help in correctly classifying fracture cases.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Ning Li, Yi Yuan, Lu Yin, Minghui Yang, Yandong Liu, Wenshuang Zhang, Kangkang Ma, Fengyun Zhou, Zitong Cheng, Ling Wang, Xiaoguang Cheng
Summary: This study investigated the correlation between bone mineral density (BMD) of proximal femur and the type of hip fracture. It was found that intertrochanteric (IT) fractures had lower BMD compared to femoral neck (FN) fractures. However, unstable IT fractures had higher BMD compared to stable ones. Higher BMD in total hip and IT were associated with IT A2 fractures, while lower bone measurements were risk factors for stable IT fractures. Understanding the biomechanics of different fracture types could improve clinical management.
Article
Geriatrics & Gerontology
Ling Wang, Lu Yin, Minghui Yang, Yufeng Ge, Yandong Liu, Yongbin Su, Zhe Guo, Dong Yan, Zhengyang Xu, Pengju Huang, Jian Geng, Xingli Liu, Gang Wang, Glen M. Blake, Weiming Cao, Bo He, Liang Lyu, Xiaoguang Cheng, Xinbao Wu, Lihong Jiang, Annegreet Vlug, Klaus Engelke
Summary: This study investigates specific risk factors for second hip fractures and finds significant associations with areal bone mineral density (aBMD), muscle size, and density. The study also shows that muscle parameters can predict the risk of contralateral fractures independently of aBMD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Orthopedics
Xin Jiang
Summary: This study investigated the efficacy of the Locking Compression Pediatric Hip Plate (TM) in treating pediatric proximal femoral tumors. The results showed that internal fixation with this plate achieved good therapeutic effects and resolved the shortcomings of traditional fixation methods.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, General & Internal
Christoph Linhart, Manuel Kistler, Maximilian Saller, Axel Greiner, Christopher Lampert, Matthias Kassube, Christopher A. Becker, Wolfgang Boecker, Christian Ehrnthaller
Summary: Osteoporotic proximal femur fractures are increasing due to demographic change. Cephalomedullary nailing is the most commonly used surgical treatment for per/subtrochanteric fractures. Cement augmentation, which has been shown to increase primary stability, is becoming more popular in the treatment of osteoporotic per/subtrochanteric femur fractures. The goal is to achieve stable osteosynthesis and promote rapid full weight-bearing to reduce postoperative complications. Bioresorbable bone cements have been developed in recent years and are primarily used to fill bone voids. This study evaluated the biomechanical stability and microstructural behavior of bioresorbable bone cements compared to conventional polymethylmethacrylate (PMMA) cements in a subtrochanteric femur fracture model. The results showed no significant differences between the two types of bone cements, indicating that bioresorbable bone cements may be a promising alternative to PMMA cements.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Xianchao Zhou, Xiang Shen
Summary: In elderly hip fracture patients, closed reduction intramedullary nailing of proximal femur has less surgical trauma and lower complication rates, but slower postoperative recovery compared with hip arthroplasty.
FRONTIERS IN SURGERY
(2022)
Article
Geriatrics & Gerontology
Aicha Goubar, Finbarr C. Martin, Catherine Sackley, Nadine E. Foster, Salma Ayis, Celia L. Gregson, Ian D. Cameron, Nicola E. Walsh, Katie J. Sheehan
Summary: The stratify-hip algorithm was developed and validated to predict the risk of in-hospital death, 30-day death, and residence change after hip fracture. The algorithm demonstrated good calibration and discrimination, and categorized patients into low, medium, and high-risk groups. This algorithm provides a new tool for risk stratification of patients with hip fracture.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Alexander Martin Keppler, Moritz Kraus, Matthias Blaschke, Nicole Thomasser, Christian Kammerlander, Wolfgang Boecker, Carl Neuerburg, Ulla Cordula Stumpf
Summary: The study found that overall willingness of osteoporosis patients to undergo further diagnosis was low, with patients with distal radius fractures showing significantly lower awareness compared to proximal femur fracture patients. Younger patients tended to underestimate the risks of osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Kieran J. Bennett, Claudio Pizzolato, Saulo Martelli, Jasvir S. Bahl, Arjun Sivakumar, Gerald J. Atkins, Lucian Bogdan Solomon, Dominic Thewlis
Summary: This study used a musculoskeletal modelling framework to compare different methods for estimating knee joint loading, and found that using EMG-informed modelling allows for better estimation of knee joint loading.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Orthopedics
Lucas T. Thomeer, Shanyuanye Guan, Hans A. Gray, Marcus G. Pandy
Summary: The study used mobile biplane X-ray imaging and magnetic resonance imaging to measure cartilage contact regions and thickness during six functional activities. It found that the contacted cartilage regions were significantly thicker than non-contacted regions, and the location of contact centers was closely related to the knee joint flexion angle.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biology
Maxence Lavaill, Saulo Martelli, Graham K. Kerr, Peter Pivonka
Summary: This study assessed the influence of marker misplacements (offset) and soft-tissue artifacts (STA) on shoulder kinematics and kinetics. The results showed that soft-tissue artifacts contribute more to the errors in shoulder kinematics and kinetics compared to marker misplacements.
Article
Sport Sciences
Yi-Chung Lin, Marcus G. Pandy
Summary: This study combined a full-body musculoskeletal model with dynamic optimization theory to predict the biomechanics of maximum-speed sprinting and evaluate the effects of changes in muscle-tendon properties on sprint performance. The results showed that sprint performance was most sensitive to changes in muscle strength and least affected by changes in tendon compliance. Additionally, muscle fascicle length had a greater impact on sprint performance compared to muscle intrinsic maximum shortening velocity.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Gina Bertocci, John R. Hutchinson, Denis J. Marcellin-Little, Marcus G. Pandy
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Shanyuanye Guan, Hans A. Gray, Lucas T. Thomeer, Marcus G. Pandy
Summary: This study aimed to compare the accuracy of different degrees of freedom models in predicting three-dimensional knee motion. The results showed that the two-degree-of-freedom model predicted knee kinematics more accurately than the one-degree-of-freedom model.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Orthopedics
R. Y. Nigel Kour, Shanyuanye Guan, Michelle M. Dowsey, Peter F. Choong, Marcus G. Pandy
Summary: The study aimed to compare the knee joint motion of three different total knee arthroplasty implant designs during daily activities, and found that the medial-stabilized design had motion patterns closer to a healthy knee joint.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Dermot O'Rourke, Francesca Bucci, William S. Burton, Rami Al-Dirini, Mark Taylor, Saulo Martelli
Summary: This study used a partial least squares regression model to determine the relationship between tibiofemoral bone geometry and passive motion of the knee. The results showed that anterior-posterior translation of the knee was mainly influenced by geometric changes in specific surface congruencies of the tibial and femoral condyles, while internal-external rotation was mainly influenced by femoral condyle width, tibia plateau size and conformity, and tibia eminences heights. Overall knee size had a significant impact on abduction-adduction motion. Understanding the complex relationship between tibiofemoral bone geometry and passive kinematics can help personalize treatments for better functional outcomes in patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Engineering, Biomedical
Saeed Miramini, Ganesharajah Ganadhiepan, Yi-Chung Lin, Minoo Patel, Martin Richardson, Marcus Pandy, Lihai Zhang
Summary: Designing weight-bearing exercises for patients with lower-limb bone fractures is challenging due to the lack of understanding on the effect of weight-bearing exercises on the bone healing process. Current models do not account for the effects of muscle loading, which could play an important role in mediating the mechanical microenvironment of a fracture site.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biophysics
Maxence Lavaill, Saulo Martelli, Kenneth Cutbush, Ashish Gupta, Graham K. Kerr, Peter Pivonka
Summary: The Latarjet procedure is a surgical method used to stabilize the glenohumeral joint after anterior dislocations. This study aims to predict the changes in muscle lever arms, muscle forces, and joint forces following the Latarjet procedure using a computational approach. The results show that the Latarjet procedure leads to alterations in muscle recruitment and increased compression force, which contributes to the stability of the glenohumeral joint during planar motions.
JOURNAL OF BIOMECHANICS
(2023)
Article
Sport Sciences
Kaiwen Yang, Wen-Tzu Tang, Shu-Hua Liu, Marcus G. Pandy
Summary: Increasing the vertical velocity of the center of mass (COM) while minimizing the loss in forward velocity (running speed) during the take-off phase is crucial for long jump performance, but the precise mechanism behind this is not fully understood. This study used a musculoskeletal model and dynamic optimization theory to simulate the biomechanics of the long jump take-off and determine the contributions of different leg muscles to jump performance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Engineering, Mechanical
Zilin Li, Huajiang Ouyang, Yuantong Gu, Saulo Martelli, Shiyu Yang, Hongtao Wei, Wei Wang, Ron-Han Wei
Summary: This study proposes a new mix-level time iteration scheme for simulating non-smooth/discontinuous systems with elastic contact and friction. It provides a generic and effective approach for different systems with the same contact features. Through detailed dynamic analysis of a 10-DoF system with two sliders, interesting findings regarding mode-coupling instability, non-smoothness, and the influences of contact states on vibration frequency and non-stationary vibration range are reported.
NONLINEAR DYNAMICS
(2023)
Article
Biophysics
Corey J. Miller, Edmund Pickering, Saulo Martelli, Enrico Dall'Ara, Peter Delisser, Peter Pivonka
Summary: The present study aimed to quantify local cortical bone adaptation and determine its universality or region specificity in response to different peak loads. By analyzing mouse tibia loading model data, the study found that local bone adaptation responses were quasi-linear and region specific. Furthermore, a mechanostat model that considered the differences in bone regions and strain directions showed the lowest error and higher prediction accuracy. However, the variability between animals and loaded versus control limbs posed challenges for simulating local surface-based adaptation responses.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Review
Biophysics
Kellie M. Halloran, Michael D. K. Focht, Alexander Teague, Joseph Peters, Ian Rice, Mariana E. Kersh
Summary: This paper examines the risk of shoulder injuries in wheelchair users during exercise and explores the kinetics and kinematics during various propulsion modes. Understanding the mechanisms behind soft-tissue injury and the associated risk factors can inform exercise guidelines for wheelchair users.
JOURNAL OF BIOMECHANICS
(2023)
Article
Rehabilitation
Markus Puchinger, Nithin Kurup, Karin Gstaltner, Marcus G. Pandy, Margit Gfohler
Summary: This study investigated the differences between a novel handle-based wheelchair propulsion device and conventional push-rim propulsion. It found that using the handle-based device resulted in lower physical responses and higher mechanical efficiency, making it a suitable alternative for indoor use.
JOURNAL OF REHABILITATION MEDICINE
(2022)