Article
Endocrinology & Metabolism
Christian Meier, Richard Eastell, Dominique D. Pierroz, Nancy E. Lane, Nasser Al-Daghri, Atsushi Suzuki, Nicola Napoli, Ambrish Mithal, Marlene Chakhtoura, Ghada El-Hajj Fuleihan, Serge Ferrari
Summary: This review provides a summary of current data on biochemical markers in relation to bone fragility and fracture risk in diabetes. The results show that although bone resorption and bone formation markers are not effective predictors of fracture risk in diabetes, osteoporosis drugs have similar effects on bone turnover markers in both diabetics and nondiabetics, resulting in reduced fracture risk. Other biochemical markers related to bone and glucose metabolism, such as sclerostin, glycated hemoglobin A(1c), and inflammatory markers, as well as hormones like insulin-like growth factor-1 and calciotropic hormones, are also associated with bone mineral density and fracture risk in diabetes. HbA(1c) levels appear to be the most reliable estimate of fracture risk, while bone turnover markers can be used to monitor the effects of antiosteoporosis therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Cassandra Smith, Alexander Tacey, Jakub Mesinovic, David Scott, Xuzhu Lin, Tara C. Brennan-Speranza, Joshua R. Lewis, Gustavo Duque, Itamar Levinger
Summary: This systematic review examined the effects of acute aerobic, resistance, and impact exercises on bone turnover markers in middle and older-aged adults, finding that the response to exercise appears to be exercise modality-, intensity-, age-, and sex-specific. Further high-quality and larger randomized controlled trials are needed in this area.
Article
Endocrinology & Metabolism
Biagio Palmisano, Mara Riminucci, Gerard Karsenty
Summary: Aerobic exercise has been found to positively influence bone remodeling, and the study aimed to investigate the role of interleukin-6 (IL-6) signaling in bone during exercise. The study showed that IL-6 receptor expression in bones increased with aerobic exercise. However, mice lacking the IL-6 receptor in osteoblasts showed impaired bone mass, remodeling, and formation when subjected to aerobic exercise, indicating the importance of IL-6 signaling in promoting bone turnover during exercise.
Article
Endocrinology & Metabolism
Cassandra Smith, Danielle Hiam, Alexander Tacey, Xuzhu Lin, Mary N. Woessner, Navabeh Zarekookandeh, Andrew Garnham, Paul Chubb, Joshua R. Lewis, Marc Sim, Markus Herrmann, Gustavo Duque, Itamar Levinger
Summary: Bone and muscle are closely linked, and hormones secreted during bone remodeling may be related to muscle mass and strength maintenance. The relationship between bone turnover markers and muscle function in older adults is unclear. This study found that higher levels of bone turnover markers were associated with better muscle function in older adults.
Article
Nutrition & Dietetics
Nina Wittorff Jensen, Kim Katrine Bjerring Clemmensen, Marie Moller Jensen, Hanne Pedersen, Kristine Faerch, Lars Jorge Diaz, Jonas Salling Quist, Joachim Storling
Summary: The postprandial responses of gut hormones GIP, GLP-1, and PYY are associated with the bone resorption marker CTX, indicating a link between gut hormones and bone homeostasis following food intake.
Article
Endocrinology & Metabolism
Jakob Kau Starup-Linde, Rikke Viggers, Bente Langdahl, Soeren Gregersen, Simon Lykkeboe, Aase Handberg, Peter Vestergaard
Summary: Osteoglycin levels were similar in patients with type 1 and type 2 diabetes, and were not correlated with glucose, HbA1c, or any other biochemical marker of bone turnover. This suggests that there is no evidence supporting the existence of an osteoglycin-bone-pancreas axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaowei Jia, He Gong, Yingying Zhang, Hongmei Liu, Haipeng Cen, Rui Zhang, Yubo Fan
Summary: This study assessed and predicted femoral strength and its influencing factors in elderly men with type 2 diabetes mellitus (T2DM). The results showed that femoral strength was higher in the T2DM group, which may be caused by higher bone mineral density and lower bone turnover rate. In addition to bone density and bone formation level, advanced glycation end products (AGEs), blood glucose, and age may significantly impact the prediction of femoral strength in T2DM.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Pediatrics
Panagiota Klentrou, Katherine McKee, Brandon J. McKinlay, Nigel Kurgan, Brian D. Roy, Bareket Falk
Summary: The study showed that short-term high-impact intense training had no direct catabolic impact on bone metabolism, with Greek yogurt providing no additional benefit beyond that of an isocaloric carbohydrate control pudding.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ian H. de Boer, Jye-Yu C. Backlund, Valerie Arends, Rose Gubitosi-Klug, Amisha Wallia, Naina Sinha Gregory, Annette Barnie, Andrew J. Burghardt, John M. Lachin, Barbara H. Braffett, Ann Schwartz
Summary: Poor glycemic control is associated with reduced bone formation in T1D patients, while reduced kidney function is associated with increased bone resorption and formation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Chuangxin Lin, Zhong Chen, Dong Guo, Laixi Zhou, Sipeng Lin, Changchuan Li, Shixun Li, Xinjia Wang, Bendan Lin, Yue Ding
Summary: This study investigated the role of osteopontin (OPN) in the subchondral bone changes of osteoarthritis (OA) and found that increased expression of OPN accelerates the turnover and remodeling of subchondral bone and mediates articular cartilage degeneration induced by subchondral bone metabolism. Additionally, inhibition of the PI3K/AKT signaling pathway was found to inhibit OPN-mediated subchondral bone remodeling and cartilage degeneration.
Article
Nutrition & Dietetics
Sakda Arj-Ong Vallibhakara, Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, Orawin Vallibhakara
Summary: The study suggests that vitamin E (mixed-tocopherol) supplementation may have a preventive effect on bone loss in postmenopausal osteopenic women through anti-resorptive activity.
Article
Oncology
Paola Muggeo, Massimo Grassi, Vito D'Ascanio, Vincenzo Brescia, Antonietta Fontana, Laura Piacente, Francesca Di Serio, Paola Giordano, Maria Felicia Faienza, Nicola Santoro
Summary: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy with a 90% 5-year survival rate due to intensive chemotherapy. However, chemotherapy can negatively affect bone health, leading to conditions such as osteopenia and fragility fractures. This study aims to investigate the impact of intensive chemotherapy on bone remodeling in ALL children and identify biomarkers for bone damage.
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
George A. Heckman, Alyana Karim Shamji, Raisa Ladha, Jackie Stapleton, Veronique Boscart, Rebecca S. Boxer, Lora Bruyn Martin, Lauren Crutchlow, Robert S. McKelvie
CANADIAN JOURNAL OF CARDIOLOGY
(2018)
Article
Health Care Sciences & Services
Jennifer Dickman Portz, Anton Vehovec, Mary A. Dolansky, Jennifer B. Levin, Sheana Bull, Rebecca Boxer
TELEMEDICINE AND E-HEALTH
(2018)
Article
Sport Sciences
Sarah J. Wherry, Christine M. Swanson, Pamela Wolfe, Toby Wellington, Rebecca S. Boxer, Robert S. Schwartz, Wendy M. Kohrt
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Health Care Sciences & Services
Jennifer Dickman Portz, Elizabeth A. Bayliss, Sheana Bull, Rebecca S. Boxer, David B. Bekelman, Kathy Gleason, Sara Czaja
JOURNAL OF MEDICAL INTERNET RESEARCH
(2019)
Article
Sport Sciences
Wendy M. Kohrt, Pamela Wolfe, Vanessa D. Sherk, Sarah J. Wherry, Toby Wellington, Edward L. Melanson, Christine M. Swanson, Connie M. Weaver, Rebecca S. Boxer
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Physiology
Sarah J. Wherry, Pamela Wolfe, Robert S. Schwartz, Wendy M. Kohrt, Catherine M. Jankowski
Summary: Taking ibuprofen before exercise reduces the inflammatory response to exercise but does not affect bone biomarkers in older adults. Monitoring changes for a longer time interval after acute exercise may be necessary to determine if ibuprofen alters bone turnover.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Nutrition & Dietetics
Sarah J. Wherry, Ryan M. Miller, Sarah H. Jeong, Kristen M. Beavers
Summary: Caloric restriction-induced weight loss can lead to bone density loss in older adults, and while exercise has positive effects on maintaining bone density, its effectiveness in mitigating CR-induced bone loss remains uncertain.
Article
Geriatrics & Gerontology
Rebecca S. Boxer, Mary A. Dolansky, Erin L. Chaussee, Jon D. Campbell, Andrea E. Daddato, Robert L. Page, Diane L. Fairclough, Stefan Gravenstein
Summary: This study aimed to determine if implementing a heart failure disease management program (HF-DMP) in skilled nursing facilities (SNFs) improves outcomes for patients with heart failure (HF). The study found that HF-DMP reduced rehospitalization and mortality rates and improved certain aspects of patients' quality of life.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Rebecca S. Boxer, Andrea E. Daddato, Andrew Jessen, Jennifer D. Portz, Susan Shetterly
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Rebecca Boxer, Melanie L. Drace, Cheryl Kelly, Rachael Robinson, Pamela Schwartz, Jenna Ausiello, Blythe Dollar, Valerie Paolino, Angela Comer, John David Powers, John F. Steiner
Summary: This study aimed to determine if 2 versus 4 weeks of medically tailored meals (MTM) after hospitalization would improve patient outcomes. The study found that different durations of short-term MTM did not affect patient-centered or utilization outcomes.
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Social Work
Jennifer Dickman Portz, Hillary D. Lum, Sheana Bull, Rebecca S. Boxer, David B. Bekelman, Kelsey L. Ford, Kathy Gleason, Alejandra Casillas, Elizabeth A. Bayliss
JOURNAL OF SOCIAL WORK IN END-OF-LIFE & PALLIATIVE CARE
(2020)
Article
Medicine, General & Internal
Sara A. Harper, Liliana C. Baptista, Lisa M. Roberts, Sarah J. Wherry, Rebecca S. Boxer, Kerry L. Hildreth, Regina S. Seay, P. Hunter Allman, Christy S. Carter, Inmaculada Aban, Wendy M. Kohrt, Thomas W. Buford
FRONTIERS IN MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Sarah J. Wherry, Cheryl Der Ananian, Pamela D. Swan
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2019)
Meeting Abstract
Sport Sciences
Sarah J. Wherry, Christine M. Swanson, Pamela Wolfe, Rebecca S. Boxer, Rpbert S. Schwartz, Wendy M. Kohrt
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)