Article
Chemistry, Multidisciplinary
Laila H. Abdel-Rahman, Mohamed Shaker S. Adam, Nabil Al-Zaqri, Mohamed R. Shehata, Hanan El-Sayed Ahmed, Shaaban K. Mohamed
Summary: In this study, a new Schiff base ligand and its metal chelates were synthesized and characterized. The compounds showed anticancer, antibacterial, and antifungal activities, and exhibited good binding affinity to DNA.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sanjeev Kumar, Jai Devi, Amit Dubey, Deepak Kumar, Deepak Kumar Jindal, Sonika Asija, Archana Sharma
Summary: In this study, three Schiff base ligands [H2L1-H2L3] and their Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized. The structural traits of the compounds were analyzed using various techniques, and it was found that the ligands acted as tridentate (ONO) and formed complexes with octahedral geometry. The metal complexes showed multi-step decomposition in thermogravimetric analysis, leaving metal oxide as the end product. Molecular docking studies revealed favorable hydrophobic interactions between some compounds and the active site of the DNA gyrase enzyme.
RESEARCH ON CHEMICAL INTERMEDIATES
(2023)
Article
Chemistry, Inorganic & Nuclear
M. M. El-Zahed, A. Z. El-Sonbati, F. M. S. Ajadain, M. A. Diab, M. I. Abou-Dobara
Summary: In this study, a novel symmetric bis-Schiff base (H2L) was synthesized and its structure was determined using various spectral and physicochemical techniques. The synthesized compounds were found to have octahedral geometry, except for one which had a tetrahedral structure. Additionally, one of the complexes (5) exhibited the highest antibacterial activity among the ligand, complexes, and standard antibiotic.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
J. Jeevitha Rani, A. Mary Imelda Jayaseeli, S. Rajagopal, S. Seenithurai, Jeng-Da Chai, J. Dhaveethu Raja, R. Rajasekaran
Summary: A series of tetradentate N2O2 Schiff base ligands and corresponding Ni(II) complexes were synthesized and characterized. The Ni(II)-salphen complexes showed square planar geometry and non-electrolyte behavior. Density Functional Theory calculations and molecular docking analyses revealed the optimized structures and binding capabilities of these complexes with Bovine Serum Albumin. The Ni(II) complexes exhibited higher inhibitory effect against pathogenic microorganisms and significant anticancer activity, with certain complexes showing better binding affinity and anticancer potency.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Adel Z. El-Sonbati, Mostafa A. Diab, Ahmed K. El-Sayed, Mohamed Abou-Dobara, Sameh A. El-Sayad
Summary: Metal complexes of a Schiff base ligand derived from 2,4-dihydroxybenzaldehyde and p-nitroaniline were synthesized and characterized. The complexes showed antibacterial, antifungal, and cytotoxic activities, and the ligand exhibited high binding affinity to various receptors.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh, Mostafa A. Hussien
Summary: Novel anti-cancer transition metal complexes were successfully synthesized and characterized using Schiff base derived from 2-aminopyrazine and salicylaldehyde. The complexes exhibited different structures and properties under different metal ions, showing promising anti-cancer activity. The Cu(II) complex showed practical results with HOP-62 cell lines, while the Zn(II) and Co(II) complexes demonstrated non-toxicity at doses up to 370 mg/kg based on LD50 values.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Mona A. Alamri, Mutlaq. Al-Jahdali, Najlaa S. Al-Radadi, Mostafa A. Hussien
Summary: This study synthesized a series of metal complexes of triazene ligands and characterized them using various analytical methods. The cytotoxic and DNA binding activities of the complexes were studied, revealing that the Zn(II) complex exhibited the highest activity. Molecular docking results correlated well with the cytotoxicity experiments.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Abdel-Mawgoud M. Abdel-Mawgoud, Shaaban K. Mohamed, Mohamed R. Shehata, Mohamed Abdel-Hameed, Mahmoud Abd El Aleem Ali Ali El-Remaily
Summary: The current study involves the synthesis and characterization of a Schiff base ligand and its metal complexes. The coordination modes and molecular geometries of the ligand were determined by spectral data and density functional calculations. The antimicrobial and cytotoxic activities of the ligand and metal complexes were evaluated, with CuL showing the highest inhibitory and cytotoxic effects.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Ahmed M. Abu-Dief, Nouf H. Alotaibi, Eida S. Al-Farraj, Hamza A. Qasem, Seraj Alzahrani, Metwally K. Mahfouz, Aly Abdou
Summary: Coordination compounds of Ag(I), Cu(II), Ni(II), Fe(III), and VO(II) ions were synthesized and their structures were investigated. The ligand formed specific structures with the ions. The structures of the compounds were optimized using density functional theory, and critical theoretical factors were calculated. Furthermore, the biological activities of the compounds were studied using molecular docking and in vitro experiments.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Kamble Gopichand, Varukolu Mahipal, N. Nageswara Rao, Abdul Majeed Ganai, P. Venkateswar Rao
Summary: This study focuses on the preparation and characterization of a Schiff base compound (2-EBTMCP) and its complexes with Ni(II), Co(II), Zn(II), and Cu(III) using various spectroscopic methods. The research also investigates the interaction between these complexes and DNA, as well as their cytotoxic potential.
RESULTS IN CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Anmol Singh, Subir Kr Maiti, Himadri Priya Gogoi, Pranjit Barman
Summary: Metal complexes of Co(II), Zn(II), and Cu(II) with purine base Schiff base ligands L1 and L2 were synthesized and characterized. The coordination of the ligands to the metal centers and their structural details were confirmed through spectroscopic and DFT studies. The binding modes of oxygen atoms in L1 and L2 complexes were found to be different. Cobalt complexes of L1 and L2 showed high DNA binding activity, with a binding constant in the order of 105 via intercalation mode. Molecular docking study provided insights into the active binding site between the metal complexes and CT-DNA.
Article
Chemistry, Physical
Gulnur Keser Karaoglan
Summary: In this study, a new series of Schiff base metal complexes were synthesized and characterized. The thermal stability and photophysical properties of these complexes were investigated. The results showed that the metal ions affected the thermal strength and fluorescence quenching constant of the complexes, with the Cu(II) complex exhibiting the highest thermal strength. Due to their high fluorescence quenching constants, these complexes could be potential active ingredients in anticancer drug transport systems.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Zohreh Alyaninezhad, Ahmadreza Bekhradnia, Reza Zibandeh Gorgi, Zahra Ghanbarimasir, Morteza Fouladpour
Summary: A series of novel metal complexes of 4-aminoantipyrine quinoxaline were synthesized and characterized. The synthesized compounds showed potential inhibitory activity in cancer cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Mamta, Subhash, Pinki, Ashu Chaudhary
Summary: Novel synthesised Mn(II) complexes of Schiff base octaazamacrocyclic ligands showed good cytotoxicity against cancerous cell lines and antimicrobial activity against bacterial and fungal strains. The stability and properties of the ligands were determined through experimental and computational studies.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Dai-Hong Cai, Bai-Hua Chen, Qi-Yan Liu, Xue-Yi Le, Liang He
Summary: Copper complexes show potential as anticancer agents, with three new Cu(II) complexes exhibiting good antiproliferative activity against various cancer cells and DNA oxidative cleavage. The complexes also display strong binding affinity with DNA and human serum albumin. Through inducing DNA damage and ROS-mediated mitochondrial dysfunction, the Cu(II) complexes lead to cancer cell apoptosis.
DALTON TRANSACTIONS
(2022)
Article
Environmental Sciences
F. A. Ansari, M. Jabeen, I. Ahmad
Summary: This study identified a novel strain, FAP5, with multifunctional traits that effectively alleviated drought stress in wheat plants through various biochemical mechanisms. The strain demonstrated tolerance to water stress, production of plant growth-promoting traits, and biofilm formation. Inoculation with FAP5 significantly improved growth attributes, photosynthetic pigment efficiency, and antioxidative enzymatic activities in wheat plants under drought conditions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Wafa A. Alshehri, Ashjan Khalel, Khaled Elbanna, Iqbal Ahmad, Hussein H. Abulreesh
Summary: The study isolated keratin-degrading bacteria from chicken feathers, with Bacillus sp BAM3 identified as the most promising strain. Molecular characterization revealed that BAM3 is a strain of Bacillus cereus. Bioplastic synthesized from keratin and glycerol exhibited good mechanical properties, suggesting potential biotechnological applications in keratin hydrolysis processes.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Biology
Maryam Zahin, Najat A. Bokhari, Iqbal Ahmad, Fohad Mabood Husain, Abdullah Safar Althubiani, Mashael W. Alruways, Kahkashan Perveen, Misfera Shalawi
Summary: Piper nigrum exhibits potential antioxidant and antimutagenic properties, with methanol extract showing high activity and significant antibacterial activity against methicillin-resistant Staphylococcus aureus. The study also found that plant compounds can interact with DNA, reducing the interaction of mutagens with DNA.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Faizan Abul Qais, Mohammad Shavez Khan, Iqbal Ahmad, Fohad Mabood Husain, Abdulaziz Abdullah Al-kheraif, Mohammed Arshad, Pravej Alam
Summary: The study found that plumbagin has inhibitory effects on the biofilms and quorum sensing of certain pathogenic bacteria, reducing their virulence traits. Specifically, it decreased violacein production in Chromobacterium violaceum, inhibited the virulent traits of Pseudomonas aeruginosa, and reduced bacterial adherence and colonization on solid surfaces. Computational studies provided insights into the possible modes of action, showing that the protein complexes remained stable under physiological conditions. This research offers both experimental and computational evidence of the efficacy of plumbagin against biofilms and QS-controlled virulence factors of Gram-negative bacteria.
Article
Anatomy & Morphology
Faizan Abul Qais, Iqbal Ahmad, Fohad Mabood Husain, Suliman Y. Alomar, Naushad Ahmad, Fadwa Albalawi, Pravej Alam, Thamer Albalawi
Summary: The study demonstrated that the active fraction of Plumbago zeylanica was effective in inhibiting quorum sensing-regulated functions and biofilm formation in Gram-negative pathogenic bacteria.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Biotechnology & Applied Microbiology
Tahani F. H. Alahmadi, Ziab Z. Alahmadey, Sameer R. Organji, Khaled Elbanna, Iqbal Ahmad, Hussein H. Abulreesh
Summary: This study revealed the prevalence of multiple resistant Staphylococcus haemolyticus in clinical settings in Saudi Arabia, with most isolates showing resistance to three or more antimicrobial agents. The findings emphasize the emerging trend of this bacteria as a potential drug resistant pathogen, warranting further investigation into the molecular understanding of antimicrobial resistance and virulence traits of the strains.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Iqbal Ahmad, Mohammad Altaf, Saad H. Alotaibi
Summary: The intensive use of antimicrobial agents has led to the emergence of multidrug resistance among microbial pathogens. Green synthesized gold nanoparticles can effectively inhibit virulence factors and biofilm development in bacteria, showing promise in the development of anti-infective agents.
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Mohammad Shavez Khan, Iqbal Ahmad, Fohad Mabood Husain, Rais Ahmad Khan, Iftekhar Hassan, Syed Ali Shahzad, Walaa AlHarbi
Summary: This study demonstrated the significant inhibitory effect of coumarin on QS-regulated virulent traits of Gram-negative bacteria, including the suppression of various virulence factors and biofilm formation. Computational studies revealed that coumarin may inhibit quorum sensing activity through multiple mechanisms.
Article
Biochemistry & Molecular Biology
Samreen, Faizan Abul Qais, Iqbal Ahmad
Summary: Multiple drug resistance (MDR) in bacteria has become a global issue, leading to reduced efficacy of antibiotics and increased therapeutic failure. This study aimed to identify potential inhibitors for the efflux pump of AcrB protein in E. coli using molecular docking. Among the 19 screened phytocompounds, chlorogenic acid showed the highest binding affinity and may serve as a promising efflux pump inhibitor in combination therapy against E. coli.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
Rabaa Algotiml, Ali Gab-alla, Roshdi Seoudi, Hussein H. Abulreesh, Iqbal Ahmad, Khaled Elbanna
Summary: Biosynthesis of gold nanoparticles using marine algal extracts as reducing and capping agents has been studied. The different algal extracts were found to influence the shape, size, and biological activity of the synthesized nanoparticles. Ulva rigida extracts showed the lowest cytotoxicity and highest antibacterial activity.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Manal Khider, Mahmoud Zaki El-Readi, Salah Abdalrahim, Abdel Naser Zohri, Ibrahim M. Ibrahim, Hussein H. Abulreesh, Iqbal Ahmad, Khaled Elbanna
Summary: This study found that Leuconostoc EPSs, especially EPS8, have anti-cancer effects on Caco-2 colorectal cancer cells, and can improve the rheological and organoleptic properties of low-fat set yogurt.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Uzma Tayyaba, Asfia Sultan, Fatima Khan, Shariq Ahmed, Iqbal Ahmad
Summary: Emerging and re-emerging zoonoses, including the recent outbreak of monkeypox, have caused significant morbidity and mortality. It is crucial for healthcare staff to update their knowledge about this zoonotic infection and understand its broader implications.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tahani F. H. Alahmadi, Ziab Z. Alahmadey, Khaled Elbanna, Leena A. Neyaz, Iqbal Ahmad, Hussein H. Abulreesh
Summary: This study aimed to explore the prevalence and clinical characteristics of hospital acquired-Staphylococcus aureus (HA-Staphylococcus aureus) in Medina, Saudi Arabia. The findings revealed a low prevalence of HA-Staphylococcus aureus, but a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA). The high prevalence of multidrug-resistant (MDR) HA-MRSA is a cause for concern.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Article
Anatomy & Morphology
Faizan Abul Qais, Mohammad Shavez Khan, Iqbal Ahmad, Fohad Mabood Husain, Mohammed Arshad, Altaf Khan, Mohd Adil
Summary: The development of antibiotic resistant microbial pathogens has become a global health threat and a major concern in modern medicine. Plants are considered as promising source for new drugs against antimicrobial resistance (AMR) pathogens. In this study, the potential of Cinnamomum zeylanicum extract in targeting the virulence of Gram -ve pathogenic bacteria was demonstrated.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Chemistry, Multidisciplinary
Faizan Abul Qais, Iqbal Ahmad, Mohammad Altaf, Salim Manoharadas, Basel F. Al-Rayes, Mohammed Saeed Ali Abuhasil, Yaser Ayesh Almaroai
Summary: The study showed that green synthesized silver nanoparticles (AgNPs-MK) demonstrated significant inhibitory effects on biofilm development and quorum sensing controlled virulence factors of Gram negative bacteria, indicating their potential in addressing the issue of antimicrobial resistance.