Article
Genetics & Heredity
Juan Tan, Weinan Pan, Huilin Chen, Yafang Du, Peiyong Jiang, Dianmei Zeng, Jie Wu, Kuang Peng
Summary: The study demonstrated that circ_0124644 plays an important role in the progression of acute myocardial infarction (AMI). Silencing circ_0124644 can alleviate hypoxia-induced cardiomyocytes injury by targeting the miR-590-3p/SOX4 axis. Therefore, circ_0124644 may be a potential target for alleviating AMI.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Cell Biology
Alireza Bakhshi, Mohammad Khani, Saeed Alipour Parsa, Isa Khaheshi, Mohammad Hassan Namazi, Arash Mazouri, Peyman Bidram, Morteza Safi, Hossein Vakili, Vahid Eslami, Habib Saadat, Laleh Heidari, Nasim Sohrabifar
Summary: The expression levels of miR-17-3p, miR-101-3p, miR-335-3p, miR-296-3p, and NLRP3 were evaluated in STEMI, NSTEMI, and control groups. NLRP3 was upregulated in both STEMI and NSTEMI patients, while miR-17-3p, miR-101-3p, and miR-296-3p were downregulated. MiR-17-3p showed the highest diagnostic power in distinguishing STEMI patients from controls.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang, Dianquan Zhang
Summary: The study investigated the potential of MSC-derived exosomes containing miR-542-3p in preventing ischemia-induced inflammatory response in glial cells by targeting TLR4. The results showed a decrease in miR-542-3p and an increase in TLR4 in MCAO mice, and overexpression of miR-542-3p alleviated cell apoptosis and inflammation induced by OGD. The delivery of exosome-miR-21-3p from MSCs also showed potential in relieving cerebral injury and inflammation caused by MCAO or OGD.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Pharmacology & Pharmacy
Thomashire A. George, Chuan-Chih Hsu, Annette Meeson, David J. Lundy
Summary: This review summarizes the principles, developments, and challenges of nanocarriers for myocardial infarction therapy, with a focus on ligand-based and cell mimicry-based targeting. It provides guidance and insights for further research and clinical applications.
Article
Biochemistry & Molecular Biology
Liana Maries, Alexandra Ioana Moatar, Aimee Rodica Chis, Catalin Marian, Constantin Tudor Luca, Ioan-Ovidiu Sirbu, Dan Gaita
Summary: Left ventricle remodeling after acute myocardial infarction leads to heart failure, but predicting this remodeling is challenging. This study found that the microRNA miR-22 can accurately distinguish between patients with and without left ventricle remodeling. The predictive power of miR-22 is even better when combined with other clinical variables. miR-22 may be a useful predictor of ventricular function recovery in STEMI patients.
Article
Cell Biology
Shilan Shafei, Mehdi Khanmohammadi, Hossein Ghanbari, Vajihe Taghdiri Nooshabadi, Seyed Hossein Ahmadi Tafti, Sharam Rabbani, Maniya Kasaiyan, Mohsen Basiri, Gholamreza Tavoosidana
Summary: This study demonstrated that combination treatment of microRNA-126 and microRNA-146a mimics in exosomes is desirable for cardiac regeneration after myocardial infarction. Exosomes loaded with microRNAs showed a synergistic impact on cell migration and tube formation, and encapsulating them in alginate hydrogel could reduce infarct size and improve angiogenesis in myocardial infarction.
CELL AND TISSUE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Ju-Ro Lee, Woo-Sup Sim, Hun-Jun Park, Bong-Woo Park, Yoon Ki Joung
Summary: The modulation of inflammatory responses is important in the development of cardiac failure. In this study, apoptotic bodies-mimetic nanovesicles derived from apoptotic fibroblasts were developed as a therapeutic strategy for ischemia-reperfusion (IR)-injured hearts. These nanovesicles actively targeted the ischemic myocardium and polarized macrophages to alleviate inflammation. Injection of the nanovesicles attenuated cardiac remodeling and prevented cardiac function exacerbation in IR-injured hearts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Dan Yang, Yinxian Chen, Zhen Ning Tony He, Yichen Wang, Chenghui Ke, Yi Luo, Sun Wang, Qichao Ma, Mengjie Chen, Qing Yang, Ziming Zhang
Summary: This study found that the immunosuppressive enzyme IDO1 is highly expressed in osteosarcoma tissues and is related to immune tolerance and progression of the tumor. Experimental results showed that IDO1 significantly affects exosome-derived miRNA subsets from osteosarcoma cells. The key miRNA hsa-miR-23a-3p involved in the progression of osteosarcoma was identified. Targeting IDO1-mediated hsa-miR-23a-3p could be a potential therapeutic strategy for osteosarcoma treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ya Guan, Hong Niu, Jiaxing Wen, Yu Dang, Mohamed Zayed, Jianjun Guan
Summary: This study presents infarcted heart-targeting, oxygen-releasing nanoparticles that can be delivered by intravenous injection at the acute myocardial infarction (MI) stage and specifically accumulate in the infarcted heart. These nanoparticles enhance cardiac cell survival, stimulate angiogenesis, and suppress fibrosis without inducing substantial inflammation and reactive oxygen species overproduction.
Article
Biochemistry & Molecular Biology
Marta Gil-Martinez, Clara Lorente-Sorolla, Jose M. Rodrigo-Munoz, Sara Naharro, Zahara Garcia-de Castro, Joaquin Sastre, Marcela Valverde-Monge, Santiago Quirce, Maria L. Caballero, Jose M. Olaguibel, Victoria del Pozo
Summary: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Abdlay Carvalho, Zhenjun Ji, Rui Zhang, Wenjie Zuo, Yangyang Qu, Xi Chen, Zaixiao Tao, Jingjing Ji, Yuyu Yao, Genshan Ma
Summary: Cardiac fibrosis following myocardial infarction is a major risk factor for heart failure. Recent evidence suggests that miR-195-3p is up-regulated in fibrotic diseases, including kidney and liver fibrosis. However, its function and underlying mechanisms in cardiac fibrosis after MI remain unknown. This study found that inhibiting the expression of miR-195-3p can reduce myofibroblast differentiation and collagen deposition in cardiac fibroblasts, as well as protect cardiac function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Issei Seki, Hiroto Izumi, Naomichi Okamoto, Atsuko Ikenouchi, Yasuo Morimoto, Seichi Horie, Reiji Yoshimura
Summary: This study examined the association between miRNA levels in extracellular vesicles (EVs) from serum and the severity of Major Depression (MD). The expression levels of hsa-miR-6813-3p and hsa-miR-2277-3p were found to be significantly downregulated with increasing depression severity of MD. These miRNAs could serve as novel biomarkers for MD and contribute to understanding its pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Bo Wang, Chang Cao, Dongjian Han, Jing Bai, Jiacheng Guo, Qianqian Guo, Demin Li, Jianchao Zhang, Zenglei Zhang, Yunzhe Wang, Junnan Tang, Deliang Shen, Jinying Zhang
Summary: Plasma exosomes derived from convalescent AMI patients showed impaired ability to repair damaged cardiomyocytes compared to those from healthy controls, potentially due to dysregulation of miR-342-3p. The study also revealed that miR-342-3p promoted exosome-mediated heart repair by targeting SOX6 and TFEB to inhibit cardiomyocyte apoptosis and autophagy. These findings provide insights into the role of plasma exosomes in cardiac repair after AMI and suggest potential therapeutic strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Yeuni Yu, Sohee Park, Hansong Lee, Eun Jung Kwon, Hae Ryoun Park, Yun Hak Kim, Seung-Geun Lee
Summary: This study aimed to develop potential biomarkers for rheumatoid arthritis (RA) by sequencing small non-coding RNA (sncRNA) in circulating exosomes. The expression levels of hsa-miR-335-5p and hsa-miR-486-5p were found to be higher in RA patients compared to healthy controls, while the expression of the SRSF4 gene was decreased. These findings suggest that circulating exosomal miRNAs and SRSF4 could serve as valuable biomarkers for RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)