Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease

STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model

(2016) A. C. Gavino et al.   ALLERGY

Biomarkers of Airway Type-2 Inflammation and Integrating Complex Phenotypes to Endotypes in Asthma

(2016) Michael C. Peters et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Novel Biologicals for the Treatment of Allergic Diseases and Asthma

(2016) Hern-Tze Tina Tan et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Regulation of group 2 innate lymphoid cells

(2016) Claudia U. Duerr et al.   CYTOKINE

Severe asthma: Current management, targeted therapies and future directions-A roundtable report

(2016) Vanessa M. McDonald et al.   RESPIROLOGY

Origin, Localization, and Immunoregulatory Properties of Pulmonary Phagocytes in Allergic Asthma

(2016) Franziska Hoffmann et al.   Frontiers in Immunology

The BCL-2 protein family, BH3-mimetics and cancer therapy

(2015) A R D Delbridge et al.   CELL DEATH AND DIFFERENTIATION

High-Density Lipoprotein-Targeted Therapy and Apolipoprotein A-I Mimetic Peptides

(2015) Yoshinari Uehara et al.   CIRCULATION JOURNAL

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

(2015) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Group 2 innate lymphoid cells and asthma

(2015) Hiroki Kabata et al.   ALLERGOLOGY INTERNATIONAL

SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function

(2015) Chulbul M. I. Ahmed et al.   Frontiers in Immunology

Long-Acting Beta Agonists Enhance Allergic Airway Disease

(2015) John M. Knight et al.   PLoS One

Mycoplasma pneumoniae Modulates STAT3-STAT6/EGFR-FOXA2 Signaling To Induce Overexpression of Airway Mucins

(2014) Yonghua Hao et al.   INFECTION AND IMMUNITY

Airway surface mycosis in chronic TH2-associated airway disease

(2014) Paul C. Porter et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Developmental Control of Integrin Expression Regulates Th2 Effector Homing

(2014) S.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Intranasal fungal (Alternaria) infection related to nasal steroid spray

(2013) Geng-He Chang et al.   AMERICAN JOURNAL OF OTOLARYNGOLOGY

Impact on L-carnitine Homeostasis of Short-term Treatment with the Pivalate Prodrug Tenofovir Dipivoxil

(2013) Yan-Yan Jia et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

CD11a polymorphisms regulate TH2 cell homing and TH2-related disease

(2013) John M. Knight et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

(2013) Xuexian O Yang et al.   NATURE IMMUNOLOGY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Central Role of Cellular Senescence in TSLP-Induced Airway Remodeling in Asthma

(2013) Jinxiang Wu et al.   PLoS One

Pharmacokinetic modeling as an approach to assessing the safety of residual formaldehyde in infant vaccines

(2013) Robert J. Mitkus et al.   VACCINE

Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6

(2013) Pietro Morlacchi et al.   ACS Medicinal Chemistry Letters

IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages

(2012) Ashish Bhattacharjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses

(2011) Camille A. Knosp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potent and Selective Phosphopeptide Mimetic Prodrugs Targeted to the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3

(2011) Pijus K. Mandal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Distinct Signal Codes Generate Dendritic Cell Functional Plasticity

(2010) K. Arima et al.   Science Signaling

Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi

(2009) P Porter et al.   Mucosal Immunology

Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3

(2009) Pijus K. Mandal et al.   ORGANIC LETTERS