期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 293, 期 21, 页码 8295-8296出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.H118.002880
关键词
-
资金
- NCI, National Institutes of Health [CA098912]
- U. S. Department of Veterans Affairs [I01BX001040]
Notch signaling plays critical roles in cancer progression, motivating efforts to identify inhibitors of this pathway. Perron et al. report a small-molecule screen intended to discover compounds that could interfere with the downstream transcription factor HES1. Target validation of their compounds unexpectedly identified a novel HES1-interacting protein, prohibitin 2. This highlights a new mechanism to block Notch signaling and prompting further exploration of HES1 biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据