TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+adipose tissue macrophage production in obese mice

Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4

(2018) Ailing Liu et al.   Nature Communications

Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice

(2017) Caroline Tao et al.   ENDOCRINOLOGY

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

TRIF-dependent Toll-like receptor signaling suppressesScd1transcription in hepatocytes and prevents diet-induced hepatic steatosis

(2017) Jing Chen et al.   Science Signaling

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity

(2017) Brittney R. Coats et al.   Cell Reports

TRIF-dependent Toll-like receptor signaling suppressesScd1transcription in hepatocytes and prevents diet-induced hepatic steatosis

(2017) Jing Chen et al.   Science Signaling

Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance

(2016) Kae Won Cho et al.   JOURNAL OF IMMUNOLOGY

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

TLR4 Expression in Bone Marrow-Derived Cells Is Both Necessary and Sufficient to Produce the Insulin Resistance Phenotype in Diet-Induced Obesity

(2015) Daniela S. Razolli et al.   ENDOCRINOLOGY

Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity

(2015) Kanakadurga Singer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Hematopoietic Stem Cell Expansion and Common Lymphoid Progenitor Depletion Require Hematopoietic-Derived, Cell-Autonomous TLR4 in a Model of Chronic Endotoxin

(2015) Ailing Liu et al.   JOURNAL OF IMMUNOLOGY

Innate Immune Programing by Endotoxin and Its Pathological Consequences

(2015) Matthew C. Morris et al.   Frontiers in Immunology

Adipose Tissue Macrophages Promote Myelopoiesis and Monocytosis in Obesity

(2014) Prabhakara R. Nagareddy et al.   Cell Metabolism

Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

(2014) Mario Kratz et al.   Cell Metabolism

Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

(2014) Shinya U. Amano et al.   Cell Metabolism

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

(2014) Minjia Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

(2014) Kanakadurga Singer et al.   Molecular Metabolism

Blood spotlight on leukocytes and obesity

(2013) J. B. C. Carvalheira et al.   BLOOD

Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation

(2013) Xiaoyuan Xu et al.   Cell Metabolism

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Regulation of Hematopoietic Stem Cell Activity by Inflammation

(2013) Laura G. Schuettpelz et al.   Frontiers in Immunology

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice

(2012) M Rachel Richards et al.   Innate Immunity

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism

(2012) J. Norseen et al.   MOLECULAR AND CELLULAR BIOLOGY

CX3CR1 Deficiency Does Not Influence Trafficking of Adipose Tissue Macrophages in Mice With Diet-Induced Obesity

(2012) David L. Morris et al.   Obesity

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Nuclear factor high-mobility group box1 mediating the activation of toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice

(2011) Liang Li et al.   HEPATOLOGY

Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity

(2010) J. M. Wentworth et al.   DIABETES

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes

(2010) Jeremy E. Davis et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice

(2010) Toru Hosoi et al.   PLoS One

TLR4 Inhibits Mesenchymal Stem Cell (MSC) STAT3 Activation and Thereby Exerts Deleterious Effects on MSC–Mediated Cardioprotection

(2010) Yue Wang et al.   PLoS One

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

(2009) Z.-b. Deng et al.   DIABETES

Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis

(2009) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Immature myeloid cells induced by a high-fat diet contribute to liver inflammation

(2009) Zhong-bin Deng et al.   HEPATOLOGY

MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4himonocytes in obesity

(2009) Daniel J. Westcott et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

(2008) C. N. Lumeng et al.   DIABETES