Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress

(2018) Megan C Kopp et al.   eLife

Endoplasmic reticulum proteins SDF2 and SDF2L1 act as components of the BiP chaperone cycle to prevent protein aggregation

(2017) Tsutomu Fujimori et al.   GENES TO CELLS

An unfolded protein-induced conformational switch activates mammalian IRE1

(2017) G Elif Karagöz et al.   eLife

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation

(2017) Steffen Preissler et al.   eLife

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

(2016) Britt Adamson et al.   CELL

Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e

(2016) Masatoshi Hagiwara et al.   MOLECULAR CELL

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Five Questions (with their Answers) on ER-Associated Degradation

(2016) Giorgia Brambilla Pisoni et al.   TRAFFIC

A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue

(2015) Jessica Merulla et al.   MOLECULAR BIOLOGY OF THE CELL

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

(2015) Steffen Preissler et al.   eLife

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

(2014) Julia Leitman et al.   MOLECULAR BIOLOGY OF THE CELL

Targeted protein destabilization reveals an estrogen-mediated ER stress response

(2014) Kanak Raina et al.   Nature Chemical Biology

Systemic stress signalling: understanding the cell non-autonomous control of proteostasis

(2014) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New players driving inflammation in monogenic autoinflammatory diseases

(2014) Fabio Martinon et al.   Nature Reviews Rheumatology

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Deregulation of ETS1 and FLI1 contributes to the pathogenesis of diffuse large B-cell lymphoma

(2013) P. Bonetti et al.   BLOOD

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

(2013) Claire L. Hartley et al.   HUMAN MOLECULAR GENETICS

Two phases of disulfide bond formation have differing requirements for oxygen

(2013) Marianne Koritzinsky et al.   JOURNAL OF CELL BIOLOGY

Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling

(2013) E. M. Lynes et al.   JOURNAL OF CELL SCIENCE

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP

(2012) Si Nga Sou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BootstRatio: A web-based statistical analysis of fold-change in qPCR and RT-qPCR data using resampling methods

(2012) Ramon Clèries et al.   COMPUTERS IN BIOLOGY AND MEDICINE

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

Enhanced Biosynthesis of Coagulation Factor VIII through Diminished Engagement of the Unfolded Protein Response

(2011) Harrison C. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway

(2011) G. Thibault et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO

(2010) Tsuyoshi Oikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER

(2010) Riccardo Bernasconi et al.   CURRENT OPINION IN CELL BIOLOGY

Derlin-1 overexpression ameliorates mutant SOD1-induced endoplasmic reticulum stress by reducing mutant SOD1 accumulation

(2010) Akira Mori et al.   NEUROCHEMISTRY INTERNATIONAL

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

(2008) A APOSTOLOU et al.   EXPERIMENTAL CELL RESEARCH

Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells

(2007) Yeo Kyoung Oh et al.   JOURNAL OF NEUROCHEMISTRY