Article
Biochemistry & Molecular Biology
S. Baumgartner, D. Luetjohann, C. Husche, A. Kerksiek, A. K. Groen, R. P. Mensink, J. Plat
Summary: In this study, we evaluated the concentrations of oxyphytosterol (OPS) in plasma and various tissues of two genetically modified mouse models. The findings showed that while the levels of plant sterols (PS) were significantly elevated in the plasma of the dKO mice, the concentrations of OPS were comparable or even lower. This suggests that OPS are primarily formed in the liver and their presence in plasma is due to spill-over from the liver.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoshinori Ohmura, Naoki Ishimori, Akimichi Saito, Takashi Yokota, Shunpei Horii, Satoshi Tokuhara, Kazuya Iwabuchi, Hiroyuki Tsutsui
Summary: Our study demonstrated that iNKT cells are involved in exacerbating plaque instability by activating inflammatory cells and upregulating MMP-2 in vascular tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Elisa Turini, Miriana Sarsale, Davide Petri, Michele Totaro, Ersilia Lucenteforte, Lara Tavoschi, Angelo Baggiani
Summary: Plant sterols/phytosterols can be used as a natural therapy to reduce LDL cholesterol levels, especially for patients with LDL-c levels >= 140 mg/dL and when used in dosages > 2 g/day.
Article
Psychiatry
Fang-Cheng Fan, Yang Du, Wen-Hui Zheng, Y. Peng Loh, Yong Cheng
Summary: This study demonstrates that conditional knockout of neuronal CPE leads to learning and memory deficits, hippocampal and amygdala degeneration, and reduced neurogenesis in mice.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Wenjiao Gu, Yujie Wei, Yu Tang, Shining Zhang, Shuangyi Li, Youming Shi, Fenxia Tang, Ali Mohamed Awad, Xiaowei Zhang, Futian Tang
Summary: This study investigated the effects of exogenous inorganic pyrophosphate sources ADTP and AL on atheromatous calcification in ApoE KO mice. The results showed that both ADTP and AL reduced calcification by increasing PPi levels and regulating inflammation.
Article
Biochemistry & Molecular Biology
Shi-Hui Law, Hua-Chen Chan, Guan-Ming Ke, Swetha Kamatam, Gopal Kedihithlu Marathe, Vinoth Kumar Ponnusamy, Liang-Yin Ke
Summary: Despite the availability of cholesterol-lowering drugs, atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality. Lipid moieties such as lysophosphatidylcholine (LPC) and ceramide (CER) contribute to atherogenic events. The HFD-fed apoE(-/-) mouse model shows elevated LPC and CER contents, making it suitable for developing LPC- and CER-lowering therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bowei Chen, Jian Yi, Yaqian Xu, Huiqiao Wen, Fengming Tian, Yingfei Liu, Lan Xiao, Lisong Li, Baiyan Liu
Summary: This study investigated the role of ApoE in cognitive function in aging mice through the gut microbiota-brain axis. The results showed that ApoE deletion exacerbated cognitive dysfunction, hippocampal synaptic ultrastructural damage, and dysregulation of synaptic proteins. It also altered the gut microbial makeup and hippocampal metabolic profile.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Alex P. Rickel, Hanna J. Sanyour, Courtney Kinser, Nisha Khatiwada, Hayley Vogel, Zhongkui Hong
Summary: Atherosclerosis-related cardiovascular diseases are a leading cause of mortality worldwide. Research has found that the mechanical properties of vascular smooth muscle cells are altered during atherosclerosis, contributing to the development of the disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuki Shimba, Rena Senda, Keigo Katayama, Akihito Morita, Masahiko Ikeda, Yasutomi Kamei, Shinji Miura
Summary: The research demonstrates that inducing the expression of FOXO-1 in skeletal muscle can suppress the progression of atherosclerosis in ApoE-KO mice, reducing vascular cell adhesion molecule-1 and macrophage infiltration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Hui Gao, Chunping Rao, Ruijuan Song, Shufen Han
Summary: The study demonstrated that oat fiber feeding can hinder the progression of atherosclerosis by affecting circulating oxysterols, alleviating hepatic inflammatory response, and targeting the TLR4/MyD88/NF-kB signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Plant Sciences
Teresa Altabella, Karla Ramirez-Estrada, Albert Ferrer
Summary: The genome of most plant viruses consists of a single positive-strand of RNA (+ ssRNA) and successful replication depends on the endomembrane system of infected cells, which undergoes massive proliferation and reshaping. The assembly of viral replicase complexes (VRCs) requires a coordinated interaction of virus and host factors, with high levels of sterols involved in creating an optimal microenvironment for efficient replication. The specific role and molecular mechanisms of sterols in VRC formation are still poorly understood, but manipulating plant sterol pathways may offer potential strategies to combat these infectious agents.
PLANT CELL REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
M. Martini, I Altomonte, R. Licitra, F. Bartaloni, F. Salari
Summary: The study investigated the sterol and tocopherol content in donkey milk during the first 2 months of lactation, finding cholesterol to be the main sterol and lanosterol to be of particular interest. The presence of lanosterol and phytosterols in donkey milk enhances its nutrional quality for consumers.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Bao-Shu Xie, Xin Wang, Yao-Hua Pan, Gan Jiang, Jun-Feng Feng, Yong Lin
Summary: Our study revealed that intravenous injection of AAV-PHP.eB led to more efficient transduction to the CNS in C57BL/6 mice compared to BALB/c mice, and transduction was significantly reduced in Apoe or Ldlr knockout C57BL/6 mice. Furthermore, poor CNS transduction in BALB/c mice was dramatically increased by B-cell or natural killer-cell depletion.
Article
Medical Laboratory Technology
Nina Sophia Decker, Theron Johnson, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude, Renee Turzanski Fortner
Summary: This study evaluated the correlations between free and total forms of oxysterols in breast cancer patients. The results showed strong correlations between most free and total oxysterols/sterols, providing further insight into their interrelationships in breast cancer patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Nutrition & Dietetics
Eberhard Windler, Frank-Ulrich Beil, Heiner K. Berthold, Ioanna Gouni-Berthold, Ursula Kassner, Gerald Klose, Stefan Lorkowski, Winfried Maerz, Klaus G. Parhofer, Jogchum Plat, Guenter Silbernagel, Elisabeth Steinhagen-Thiessen, Oliver Weingaertner, Birgit-Christiane Zyriax, Dieter Luetjohann
Summary: Phytosterols (PSs) have been proposed as a dietary means to lower plasma LDL-C. Observational studies show no evidence that plasma PS concentrations would be associated with an increased risk of atherosclerosis or cardiovascular events. PSs offer a dietary approach to cholesterol management based on their LDL-C lowering and absence of adverse safety signals.
Article
Medicine, Research & Experimental
Karina Thieme, Beatriz Maria Veloso Pereira, Karolline S. da Silva, Nelly T. Fabre, Sergio Catanozi, Marisa Passarelli, Maria Lucia Correa-Giannella
Summary: In non-diabetic rats, treatment with AGEs increased TXNIP expression and decreased levels of repressive epigenetic marks H3K27me3 and miR-29a, potentially leading to injury to glomerular filtration barrier and dysfunction of podocytes.
Article
Nutrition & Dietetics
Guilherme da Silva Ferreira, Ana Paula Garcia Bochi, Paula Ramos Pinto, Vanessa Del Bianco, Leticia Gomes Rodrigues, Mychel Raony Paiva Teixeira Morais, Edna Regina Nakandakare, Ubiratan Fabres Machado, Sergio Catanozi, Marisa Passarelli
Summary: The study revealed that aerobic exercise training can alleviate hepatic lipid accumulation caused by a low-sodium diet, while improving insulin sensitivity and oxidative capacity. The low-sodium diet increased the expression of genes related to insulin resistance and lipid metabolism, but AET could partially prevent these adverse effects.
Article
Immunology
Kelly Gomes Santana, Renato Fraga Righetti, Cristiane Naffah de Souza Breda, Omar Alberto Dominguez-Amorocho, Theresa Ramalho, Francisca Elda B. Dantas, Valeria Sutti Nunes, Iolanda de Fatima Lopes Calvo Tiberio, Francisco Garcia Soriano, Niels O. S. Camara, Eder Carlos Rocha Quintao, Patricia M. Cazita
Summary: CETP plays a crucial role in atherosclerosis, endotoxemia, and sepsis, impacting macrophage function and immune response. In experimental models, CETP promotes lung M2-like phenotype and exacerbates COPD, suggesting its involvement in inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Paula de Albuquerque, Viviani De Marco, Thiago Henrique Annibale Vendramini, Andressa Rodrigues Amaral, Sergio Catanozi, Kelly Gomes Santana, Valeria Sutti Nunes, Edna Regina Nakandakare, Marcio Antonio Brunetto
Summary: The study evaluated the therapeutic efficacy of omega-3 fatty acids associated with different fat content diets in Schnauzer with primary hyperlipidaemia. Both low-fat and moderate-fat diet combined with omega-3 fatty acids effectively reduced triglyceride and cholesterol levels without altering lipoprotein profile in Schnauzer with primary hyperlipidaemia.
Article
Endocrinology & Metabolism
Raphael S. Pinto, Guilherme S. Ferreira, Gina Camillo R. Silvestre, Monique de Fatima M. Santana, Valeria S. Nunes, Lucas Ledesma, Paula R. Pinto, Sayonara Ivana S. de Assis, Ubiratan F. Machado, Erasmo S. da Silva, Marisa Passarelli
Summary: Advanced glycation end products (AGEs) are independently associated with cardiovascular disease (CVD) and soluble RAGE (sRAGE) alleviates the harmful effects of AGE in atherogenesis. This study examined the correlation between plasma AGEs and sRAGE with cholesterol, oxysterols, and markers of cholesterol synthesis and absorption in atherosclerotic plaques. The results showed that symptomatic subjects had increased cholesterol and oxysterol levels in plaques compared to asymptomatic individuals. Plasma AGEs and sRAGE were correlated with sterol accumulation in plaques, while sRAGE was inversely correlated with AGEs, oxysterols, and markers of cholesterol synthesis and absorption. These findings suggest that plasma AGEs and sRAGE can predict sterol accumulation in atherosclerotic lesions.
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Mauricio Teruo Tada, Viviane Zorzanelli Rocha, Isabella Ramos Lima, Theo Gremen Mimary Oliveira, Ana Paula Chacra, Marcio Hiroshi Miname, Valeria Sutti Nunes, Edna Regina Nakandakare, Maria Helane Costa Gurgel Castelo, Cinthia Elim Jannes, Raul D. Santos, Jose Eduardo Krieger, Alexandre Costa Pereira
Summary: This study identified a substantial number of sitosterolemia patients with varying LDL-C levels and high incidence of early atherosclerotic cardiovascular disease and hematologic abnormalities through a familial hypercholesterolemia cascade screening program. Testing genes associated with sitosterolemia allowed for precise diagnosis and characterization of the disease.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Article
Nutrition & Dietetics
Valeria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patricia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintao
Summary: Non-cholesterol sterols play an important role in cholesterol metabolism, and their distribution in plasma lipoproteins varies according to HDL cholesterol levels in healthy individuals.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Valeria Sutti Nunes, Edite Vieira Silva de Campos, Jamal Baracat, Victor Franca, Erica Ivana Lazaro Gomes, Raissa Peres Coelho, Edna Regina Nakandakare, Vanessa Helena Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintao
Summary: This study investigated the relationships between plasma cholesterol synthesis and absorption markers and cardiovascular disease risk factors, cIMT, and carotid plaques in asymptomatic subjects. The findings suggested that campesterol may be associated with atherosclerotic plaques, while the ratios of lathosterol/campesterol or lathosterol/sitosterol may indicate an inverse association. This highlights the inverse relationship between cholesterol synthesis and absorption, with the absorption marker campesterol reflecting changes in body cholesterol homeostasis and atherosclerotic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ana Paula Garcia Bochi, Guilherme da Silva Ferreira, Vanessa Del Bianco, Paula Ramos Pinto, Leticia Gomes Rodrigues, Mayara da Silva Trevisani, Luzia Naoko Shinohara Furukawa, Kely Cristina Soares Bispo, Alexandre Alves da Silva, Ana Paula Pereira Velosa, Edna Regina Nakandakare, Ubiratan Fabres Machado, Walcy Paganelli Rosolia Teodoro, Marisa Passarelli, Sergio Catanozi
Summary: This study found that aerobic exercise training can prevent dyslipidemia, insulin resistance, and atherogenesis induced by severe low-sodium diet. Aerobic exercise training can improve arterial lipid infiltration, reduce AT1 receptor levels, and improve peripheral insulin resistance caused by dietary restriction. Additionally, the effects of aerobic exercise training are independent of improvements in plasma lipid profile.
Article
Medicine, General & Internal
Fernanda Andrade Macaferri da da Fonseca, Aline Paulino Esposito, Maria Helena Baptista Nunes da Silva, Valeria Sutti Nunes, Patricia Miralda Cazita, Guilherme Silva Ferreira, Maria Esther Jurfest Rivero Ceccon, Werther Brunow de Carvalho, Magda Carneiro-Sampaio, Patricia Palmeira
Summary: This study aimed to evaluate lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. The results showed that septic newborns had higher levels of IL-6 and IL-8 at admission, as well as differences in lipid profile compared to controls. Furthermore, M/H ratio and non-HDL cholesterol were identified as risk factors for septic shock.
Article
Medicine, General & Internal
Victor Franca, Erica Ivana Lazaro Gomes, Edite Vieira Silva de Campos, Vanessa Helena de Souza Zago, Valeria Sutti Nunes, Eliana Cotta de Faria
Summary: This study found that Lipoprotein (a) (Lp(a)) levels are associated with carotid plaques and intima-media thickness in healthy subjects. Lp(a) levels above 30 mg/dL contribute to an increased risk of carotid plaque development.
Article
Medicine, General & Internal
Valeria Sutti Nunes, Angela de Oliveira Godoy Ilha, Guilherme da Silva Ferreira, Renata de Paula Assis Bombo, Milessa Silva Afonso, Maria Silvia Ferrari Lavrador, Roberta Marcondes Machado, Edna Regina Nakandakare, Eder Carlos Rocha Quinta, Ana Maria Lottenberg
Summary: This study investigated the relationship between plasma phytosterols and the body's cholesterol synthesis rate. The results showed that the lathosterol-to-cholesterol plasma ratio can predict the plasma cholesterol response to phytosterol feeding.
Review
Cell Biology
Valeria Sutti Nunes, Guilherme da Silva Ferreira, Eder Carlos Rocha Quintao
Summary: Aging in humans leads to abnormal blood lipids and decreased brain cholesterol levels, which are associated with liver diseases and neurological disorders.