O-GlcNAc: a novel regulator of immunometabolism

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases

(2017) Marwa Chehimi et al.   Journal of Clinical Medicine

Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects

(2016) Chris Lanza et al.   CELL CYCLE

Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity

(2016) Valerie A. Gerriets et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Global Analysis ofO-GlcNAc Glycoproteins in Activated Human T Cells

(2016) Peder J. Lund et al.   JOURNAL OF IMMUNOLOGY

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

(2015) Chao Wang et al.   CELL

Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid Cells

(2015) Fabio R. Santori et al.   Cell Metabolism

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Leptin Receptor Signaling in T Cells Is Required for Th17 Differentiation

(2015) Bernardo S. Reis et al.   JOURNAL OF IMMUNOLOGY

Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1

(2015) Yusuke Endo et al.   Cell Reports

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation

(2014) Mako Nakaya et al.   IMMUNITY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

(2014) Tomohiro Koga et al.   JOURNAL OF CLINICAL INVESTIGATION

The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex

(2014) Emily B Heikamp et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Oxysterols are agonist ligands of ROR t and drive Th17 cell differentiation

(2014) P. Soroosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of X-Linked genes in T cells from women with lupus

(2013) Anura Hewagama et al.   JOURNAL OF AUTOIMMUNITY

O-LinkedN-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization

(2013) Ee Phie Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

Activation of the Transcriptional Function of the NF- B Protein c-Rel by O-GlcNAc Glycosylation

(2013) P. Ramakrishnan et al.   Science Signaling

The CD4-centered universe of human T cell subsets

(2013) J. Geginat et al.   SEMINARS IN IMMUNOLOGY

Peroxisome proliferator-activated receptor (PPAR)  and -  regulate IFN  and IL-17A production by human T cells in a sex-specific way

(2012) M. A. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Human Th17 Cells Comprise Heterogeneous Subsets Including IFN- -Producing Cells with Distinct Properties from the Th1 Lineage

(2010) K. Boniface et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Obesity predisposes to Th17 bias

(2009) Shawn Winer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY