4.2 Article

High-sensitivity CRP: Possible link between job stress and atherosclerosis

期刊

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
卷 58, 期 7, 页码 773-779

出版社

WILEY-BLACKWELL
DOI: 10.1002/ajim.22470

关键词

job stress; effort-reward imbalance; inflammation; C-reactive protein; atherosclerosis

资金

  1. Scientific Research Foundation for the Returned Overseas Scholars of Peking University Third Hospital [Y78504-1]
  2. National Natural Science Foundation of China [NNSFC 81400319]

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BackgroundChronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers. MethodsA total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model. ResultsAmong men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P<0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P<0.05). ConclusionsHigh effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis. Am. J. Ind. Med. 58:773-779, 2015. (c) 2015 Wiley Periodicals, Inc.

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