期刊
JOURNAL OF ANTIBIOTICS
卷 71, 期 10, 页码 902-904出版社
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0079-2
关键词
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资金
- National Natural Science Foundation of China [41776168, 41706167, 21672084, 41376155, 81302665]
- Ningbo Sci. & Tech. Projects for Common Wealth [2017C10016]
- Science and Technology Planning Project of Guangzhou [201710010088, 201704030042]
- National 111 Project of China [D16013]
- Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund
- K.C. Wong Magna Fund in Ningbo University
Three new itaconic acid derivatives, asperitaconic acids A-C (1-3), were isolated from the ethyl acetate extracts of the rice fermentation of a marine-derived fungus Aspergillus niger, and asperitaconic acids A-C were characterized by an itaconic acid unit and an alkyl chain moiety. Their structures were established by interpretation of their spectroscopic data including NMR and HRESIMS. Asperitaconic acids A-C exhibited antibacterial effect against Staphylococcus aureus with MIC values of 16-32 mu g/mL, whereas these compounds showed no cytotoxicity against HepG2 and HeLa cancer cell lines.
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