Article
Biochemistry & Molecular Biology
Laia Richart, Eleonora Lapi, Vera Pancaldi, Mirabai Cuenca-Ardura, Enrique Carrillo-de-Santa Pau, Miguel Madrid-Mencia, Helene Neyret-Kahn, Francois Radvanyi, Juan Antonio Rodriguez, Yasmina Cuartero, Francois Serra, Francois Le Dily, Alfonso Valencia, Marc A. Marti-Renom, Francisco X. Real
Summary: STAG2 is crucial in maintaining the stability of DNA looping and gene interactions within topological domains, influencing the balance between luminal and basal transcriptional programs in bladder tumors.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Pathology
Edaise M. da Silva, Francisco Beca, Ana Paula Martins Sebastiao, Melissa P. Murray, Catarina Silveira, Arnaud Da Cruz Paula, Fresia Pareja, Hannah Y. Wen, Timothy M. D'Alfonso, Marcia Edelweiss, Britta Weigelt, Edi Brogi, Jorge S. Reis-Filho, Hong Zhang
Summary: This study found MED12 exon 2 mutations in the stroma of CFAs, while TERT promoter mutations were restricted to the stroma; no mutations were detected in PIK3CA exons 9 and 20.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Oncology
Masaru Sasaki, Norikatsu Miyoshi, Shiki Fujino, Kazuhiro Saso, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Hirofumi Yamamoto, Chu Matsuda, Masayoshi Yasui, Masayuki Ohue, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: High expression of STAG3 is associated with poor prognosis in colorectal cancer, while knockdown of STAG3 inhibits cell migration and increases drug sensitivity. Particularly in BRAF-mutant CRC cells, silencing of STAG3 suppresses the expression of specific genes. STAG3 may serve as a potential prognostic marker and therapeutic target for CRC.
Article
Urology & Nephrology
Francesco Claps, Nicola Pavan, Paolo Umari, Michele Rizzo, Fabio Barbone, Manuela Giangreco, Giovanni Liguori, Carmen M. Mir, Rossana Bussani, Carlo Trombetta
Summary: The study found that incidental prostate cancer (iPCa) is common in patients undergoing radical cystectomy (RC) for bladder cancer, with most cases being organ-confined and well differentiated. Regardless of clinical relevance, iPCa does not impact survival outcomes as bladder cancer drives the prognosis of these patients.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenya Wang, Xi Zheng, Anca Azoitei, Axel John, Friedemann Zengerling, Felix Wezel, Christian Bolenz, Cagatay Guenes
Summary: TKS5 promotes invasion and migration in tumor cells and non-tumor cells. This study found that TKS5 regulates migration and invasion in bladder cancer cells and plays an important role in genome stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yi-Fan Zhou, Yi Xiao, Xi Jin, Geng-Hong Di, Yi-Zhou Jiang, Zhi-Ming Shao
Summary: This study systematically characterized the HLA-I status in triple-negative breast cancers (TNBCs) and found that HLA-I loss of heterozygosity (LOH) is an independent prognostic biomarker, especially for patients with non-immune-inflamed tumors. HLA-I LOH tumors had upregulated mutational signature 3 scores and homologous recombination deficiency scores, indicating DNA repair failure, higher mutation and neoantigen loads, and more subclones, contributing to poor immune selection pressure.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Urology & Nephrology
Logan G. Briggs, Chanan Reitblat, Paul A. Bain, Sara Parke, Ny-Ying Lam, Jonathan Wright, James W. F. Catto, Robert J. Copeland, Sarah P. Psutka
Summary: This study systematically assessed the therapeutic validity and efficacy of prehabilitation exercise programs before urologic cancer surgery. While these programs improve cardiorespiratory fitness and quality of life, their impact on surgical outcomes remains inconclusive.
Review
Oncology
Maddalena Di Nardo, Maria M. Pallotta, Antonio Musio
Summary: The cohesin complex plays a crucial role in faithful chromosome segregation, hierarchical three-dimensional organization of the genome, transcription regulation, and maintaining DNA integrity. Mutations in cohesin complex subunits have been found to be recurring in human cancers, but the mechanisms by which these mutations contribute to cancer development and progression are poorly understood. Recent discoveries have provided new insights into the role of cohesin in tumorigenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Chenyang Xu, Shuai Jiang, Lujia Zou, Lu Sheng, Guowei Shi, Bin Xu, Zhong Wang, Danfeng Xu, Xin Xie, Jianfeng Luo, Jianming Guo, Haowen Jiang
Summary: This study compared the efficacy of endoscopic balloon cryoablation (EBCA) with a single instillation of intravesical chemotherapy for bladder cancer. The results showed that EBCA had a higher local control rate than the single instillation of chemotherapy and improved patients' recurrence-free survival and progression-free survival.
Article
Oncology
Tom J. Harryvan, Marten Visser, Linda de Bruin, Leonie Plug, Lisa Griffioen, Arend Mulder, Peter A. van Veelen, Gerbrand J. van Der Heden van Noort, Marlieke Lm Jongsma, Miranda H. Meeuwsen, Emmanuel Jhj Wiertz, Saskia J. Santegoets, James Ch Hardwick, Thorbald Van Hall, Jacques Neefjes, Sjoerd H. Van der Burg, Lukas J. A. C. Hawinkels, Els M. E. Verdegaal
Summary: This study found that human CRC-derived CAFs have an enhanced ability to cross-present antigens, which involves the participation of lysosomal protease cathepsin S. The interaction between cross-presenting CAFs and CD8+ T cells suppresses T cell function.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Medicine, General & Internal
Yong-Nam Gwon, Jae-Joon Park, Ki-Soo Lee, Kong-Hee Lee, Tae-Hyo Kim, Jae-Heon Kim
Summary: Although numerous studies have been conducted on bladder cancer and the microbiome, no useful strains at the species level have been identified yet. Methodological heterogeneity is significant in urine studies, while shotgun analysis has not revealed the species level in tissue studies, and studies using stool samples have offered limited information. This review aims to comprehensively summarize all microbiome studies connected to bladder cancer through a systematic review.
Review
Biochemistry & Molecular Biology
Lucia Morales, Jesus M. Paramio
Summary: Bladder cancer presents a challenging problem in Oncology due to its high incidence and progression, leading to exploration of new avenues in its management. While immune checkpoint blockade inhibitors represent an unprecedented advance, the fraction of patients benefiting from them is limited. Cell-based therapies are promising tools for controlling solid tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Magdalena Wilczak, Magdalena Surman, Malgorzata Przybylo
Summary: Bladder cancer is the 10th most common malignancy worldwide, with a high mortality rate. Altered glycosylation of bladder cancer cells plays a crucial role in disease progression and could be used for diagnostic and therapeutic purposes.
Review
Urology & Nephrology
Rodrigo Barros, Luciano A. Favorito, Bruno Nahar, Ricardo Almeida Jr, Ranjith Ramasamy
Summary: This study aims to describe the common sexual problems and changes faced by male urological cancer survivors, with a focus on evidence-based assessment and intervention practices. Through a search of the PubMed, Embase, and SciELO databases from 1994 to 2022, relevant literature was collected. The review findings indicate that the diagnosis and treatment of urological cancers have a significant impact on male sexual function, including genital or reproductive tumors (such as prostate, penile, and testicular tumors) as well as non-genital tumors (such as bladder and kidney tumors). Therefore, patients need to be informed about the potential changes in sexual function prior to undergoing treatment for any urological cancer.
INTERNATIONAL BRAZ J UROL
(2023)
Article
Urology & Nephrology
Matthew Zibelman, Aeen M. Asghar, Daniel C. Parker, John O'Neill, Shuanzeng Wei, Richard E. Greenberg, Marc C. Smaldone, David Y. T. Chen, Rosalia Viterbo, Robert G. Uzzo, Evan Bloom, Rutika Kokate, Daniel M. Geynisman, Pooja Ghatalia, Mengying Deng, Eric A. Ross, Elizabeth Plimack, Philip H. Abbosh, Alexander Kutikov
Summary: This study aimed to evaluate the reliability and limitations of cystoscopic evaluation in candidates for radical cystectomy, showing that systematic endoscopic evaluation was unable to accurately predict post-operative pathology results. Further research is needed to explore novel imaging and biomarker strategies to optimize decision making regarding bladder preservation.
JOURNAL OF UROLOGY
(2021)