Review
Biochemistry & Molecular Biology
Alex Cleber Improta-Caria, Marcela Gordilho Aras, Luca Nascimento, Ricardo Augusto Leoni De Sousa, Roque Aras-Junior, Bruno Solano de Freitas Souza
Summary: MicroRNAs are small non-coding RNAs that regulate gene and protein expression, playing important roles in various cellular processes. In diseases such as hypertension, microRNAs are involved in regulating physiological processes, but the specific mechanisms need further study.
Article
Cardiac & Cardiovascular Systems
Kieran F. Docherty, Ross T. Campbell, Katriona J. M. Brooksbank, John G. Dreisbach, Paul Forsyth, Rosemary L. Godeseth, Tracey Hopkins, Alice M. Jackson, Matthew M. Y. Lee, Alex McConnachie, Giles Roditi, Iain B. Squire, Bethany Stanley, Paul Welsh, Pardeep S. Jhund, Mark C. Petrie, John J. V. McMurray
Summary: In patients with asymptomatic LV systolic dysfunction late after myocardial infarction, treatment with sacubitril/valsartan did not have a significant reverse remodeling effect compared with valsartan.
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Endocrinology & Metabolism
Huai Heng Loh, Norlela Sukor
Summary: This review aims to collate and summarize current research on the association between primary aldosteronism and obstructive sleep apnea, including their relationship, clinical characteristics, implications, treatment outcomes, potential causal links, and mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fedor Simko, Tomas Baka, Peter Stanko, Kristina Repova, Kristina Krajcirovicova, Silvia Aziriova, Oliver Domenig, Stefan Zorad, Michaela Adamcova, Ludovit Paulis
Summary: This study investigated whether sacubitril/valsartan and ivabradine can prevent left ventricular fibrotic remodelling and dysfunction in a rat model of hypertension, and found that the protective effects of sacubitril/valsartan may be associated with RAAS alterations, while the benefits of ivabradine were not related to RAAS modulation.
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Chunfang Xu, Ziying Zhao, Wang Yuan, Zhao Fengping, Yan Zhiqiang, Zhang Xiaoqin
Summary: The study found that allisartan lowers blood pressure and improves left ventricular remodeling by increasing the expression of Kv1.5 channels.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Cesare Cuspidi, Marijana Tadic, Carla Sala, Fosca Quarti-Trevano, Elisa Gherbesi, Giuseppe Mancia, Guido Grassi
Summary: This meta-analysis indicates that renal artery revascularization combined with antihypertensive therapy has a positive impact on LV structure, leading to a decrease in LV mass index and a lower risk of LVH.
JOURNAL OF HYPERTENSION
(2021)
Article
Pharmacology & Pharmacy
Quenia Janaina Tomaz de Castro, Carolina Morais Araujo, Patricia Yoshie Watai, Samara Stefani de Castro e Silva, Wanderson Geraldo de Lima, Lenice Kappes Becker, Jamille Locatelli, Homero Nogueira Guimaraes, Andrea Grabe-Guimaraes
Summary: The study showed that the combination of physical exercise with RAAS blockers could effectively lower blood pressure, improve cardiac parameters, and potentially benefit hypertensive LVH treatment.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Matthew A. Sparks, Fitra Rianto, Edward Diaz, Ritika Revoori, Thien Hoang, Lucas Bouknight, Johannes Stegbauer, Anuradha Vivekanandan-Giri, Phillip Ruiz, Subramaniam Pennathur, Dennis M. Abraham, Susan B. Gurley, Steven D. Crowley, Thomas M. Coffman
Summary: Deletion of AT(1A) receptors in cardiomyocytes plays a crucial role in regression of cardiac hypertrophy, independent of reducing pressure overload.
Article
Cardiac & Cardiovascular Systems
D. Marshall Brinkley, Li Wang, Chang Yu, E. Wilson Grandin, Michael S. Kiernan
Summary: In LVAD patients, treatment with ACEI/ARB but not MRA was independently associated with lower mortality. ACEI/ARB therapy was also associated with decreased risk of cardiovascular death, gastrointestinal bleeding, and creatinine level, while MRA therapy was associated with lower risk of gastrointestinal bleeding but higher risk of hemolysis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Maxime Berney, Nima Vakilzadeh, Marc Maillard, Mohamed Faouzi, Eric Grouzmann, Olivier Bonny, Lucie Favre, Gregoire Wuerzner
Summary: The study compared the effects of weight loss after RYGB surgery or dietary advice on blood pressure, RAAS, and urinary electrolyte excretion. The results showed that weight loss and plasma aldosterone concentration decrease were more pronounced in the RYGB group, with no significant difference in RAAS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nejla Latic, Mirko Peitzsch, Ana Zupcic, Jens Pietzsch, Reinhold G. Erben
Summary: Increased dietary phosphate intake is associated with severity of coronary artery disease, increased cardiovascular mortality and morbidity, but the underlying mechanisms are still unclear. A mouse experiment showed that chronic elevated dietary phosphate intake can independently cause an increase in blood pressure, possibly through activation of the RAAS and stimulation of the sympathetic tone.
Article
Medicine, General & Internal
Aleksandra Budkiewicz, Michal A. Surdacki, Aleksandra Gamrat, Katarzyna Trojanowicz, Andrzej Surdacki, Bernadeta Chyrchel
Summary: Although traditional ECG-LVH criteria have some association with echocardiographic LVH, they show distinct relationships with stenosis severity in aortic stenosis. Among these criteria, the Cornell voltage criterion has a moderate diagnostic superiority in identifying anatomic LVH.
JOURNAL OF CLINICAL MEDICINE
(2021)