Article
Biochemistry & Molecular Biology
Amy Moore, Michael P. Busch, Karolina Dziewulska, Richard O. Francis, Eldad A. Hod, James C. Zimring, Angelo D'Alessandro, Grier P. Page
Summary: The RBC-Omics study aims to understand the genetic contribution to blood donor RBC characteristics. Through genome-wide association analysis, multiple genetic loci associated with metabolites were identified, including potentially novel associations.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Guizhao Wang, Nianhua Yu, Ying Wen, Faqiang Leng
Summary: In this study, a one-pot tandem perfluoroalkylation-defluorination reaction of indole, perfluoroalkyl iodide, and water in the presence of Na2S2O4 was reported. Various indole derivatives were efficiently synthesized with good yields under mild reaction conditions. The reaction is believed to proceed through perfluoroalkylation and defluorination hydrolysis pathway. This study provides an alternative approach for defluorination functionalization.
Article
Environmental Sciences
Heidi Samantha Moraes Utsunomiya, Joao Victor Cassiel Ferraz, Gabriel Hiroshi Fujiwara, Davi Marques Gutierres, Isabela Ferreira Fernandes, Bruno Serra de Lacerda Valverde, Classius de Oliveira, Lilian Franco-Belussi, Marisa Narciso Fernandes, Cleoni dos Santos Carvalho
Summary: This study evaluated the effects of exposure to water from different sites of the Sorocaba River on genetic damage, oxidative stress, neurotoxicity, and energy metabolism in bullfrog tadpoles. The results indicated that exposure to water from different sites caused changes in various indicators, which may have effects on the development of tadpoles.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Amin Arif, Ruhul Quds, Samreen Salam, Riaz Mahmood
Summary: In this study, we found that dietary antioxidant esculin can protect human erythrocytes from oxidative damage caused by the insecticide bioallethrin. Bioallethrin induced oxidative stress, resulting in increased oxidative proteins and lipids, decreased amino groups and reduced to oxidized glutathione ratio in erythrocytes. It also increased the generation of reactive oxygen and nitrogen species, altered plasma membrane integrity, oxidized hemoglobin, and affected antioxidant enzyme activities and redox system. However, pretreatment with esculin significantly restored these parameters in a concentration-dependent manner. Therefore, esculin can be an effective chemoprotectant against xenobiotic-induced toxicity in human erythrocytes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samreen Salam, Amin Arif, Monika Sharma, Riaz Mahmood
Summary: The fungicide Thiram can cause oxidative damage in human erythrocytes, but the flavonoid glycoside Rutin has a protective effect against Thiram-induced damage, reducing oxidative stress and improving erythrocyte function.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Cell Biology
Alessia Remigante, Rossana Morabito, Angela Marino
Summary: Band 3 protein (B3p) is an anion transporter that plays a crucial role in erythrocyte homeostasis and cell shape, particularly under oxidative stress conditions. Investigating the functions and anion exchange capability of B3p is significant for understanding related diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rashmi S. Tupe, Nilima Bangar, Akib Nisar, Amruta Kulkarni, Neena Sankhe, Rohan Chauhan, Nidhi Mistry, Shamim Shaikh
Summary: Piperine demonstrates preventive, protective, and therapeutic effects on albumin glycation, while also safeguarding red blood cells from oxidative damage induced by glycated albumin.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ruhul Quds, Zarmin Iqbal, Amin Arif, Riaz Mahmood
Summary: Mancozeb induces oxidative stress and impairs the antioxidant defense system in human erythrocytes, resulting in damage to cellular components and adverse effects on erythrocyte structure and function.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Valeria Pasciu, Francesca D. Sotgiu, Cristian Porcu, Fiammetta Berlinguer
Summary: Glycerol is commonly used as a feed supplement in ruminant nutrition, but it can lead to hemolysis at high concentrations. However, the antioxidant defenses of red blood cells can protect against oxidative stress caused by glycerol-induced osmotic stress.
Article
Physiology
Nisred K. Klichkhanov, Elena R. Nikitina, Zainab M. Shihamirova, Maria D. Astaeva, Shamil I. Chalabov, Aleksandr I. Krivchenko
Summary: Small ground squirrels exhibit low levels of ROS and RNS production during hibernation, while oxidative stress increases during arousal, but decreases as body temperature recovers.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Analytical
Quanqing Zhang, Xuejiao Dong, Jiuwei Lu, Jikui Song, Yinsheng Wang
Summary: This study developed a chemoproteomic strategy to profile PFAS-binding proteins, identifying 469 putative PFOPA-binding proteins and demonstrating FABP5's direct interaction with various PFAS. The binding affinity of FABP5 varies with the structures of PFAS, setting the stage for further understanding the mechanisms of adverse health effects caused by PFAS exposure.
ANALYTICAL CHEMISTRY
(2021)
Article
Toxicology
Zarmin Iqbal, Ruhul Quds, Riaz Mahmood
Summary: Cadmium is a toxic heavy metal with no physiological role in the human body. Vanillin, a plant phenolic aldehyde and antioxidant, has been found to alleviate the toxicity of cadmium chloride (CdCl2) by reducing the generation of reactive species, preventing heme degradation and oxidation, and enhancing erythrocyte antioxidant capacity. Vanillin can potentially be used as a chemoprotectant against the damaging effects of cadmium.
TOXICOLOGY IN VITRO
(2023)
Article
Multidisciplinary Sciences
Marilyn Vasquez, Margaux Sica, Ruth Namazzi, Robert O. Opoka, Julian Sherman, Dibyadyuti Datta, Miquel Duran-Frigola, John M. Ssenkusu, Chandy C. John, Andrea L. Conroy, Ana Rodriguez
Summary: Severe anemia is a significant cause of mortality in children with severe malaria. Elevated levels of xanthine oxidase (XO) were found in children with severe anemia, indicating a relationship between this oxidative enzyme and the anemia. XO was not associated with immune complexes and autoimmune antibodies, suggesting that it contributes to severe anemia through an independent mechanism. Additionally, XO was associated with other complications of severe malaria. Inhibitors of XO could potentially be used as adjunctive therapy for malaria.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Manas Kotepui, Kwuntida Kotepui, Aongart Mahittikorn, Hideyuki J. Majima, Jitbanjong Tangpong, Hsiu-Chuan Yen
Summary: This systematic review and meta-analysis found that GSH levels were generally lower in malaria patients. There was no significant difference in GSH levels between Plasmodium falciparum and P. vivax malaria, as well as between symptomatic and asymptomatic malaria cases.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Environmental
Menglin Liu, Shujun Yi, Hao Yu, Tianxu Zhang, Fengfeng Dong, Lingyan Zhu
Summary: This study investigated the sex-specific hepatotoxicity of emerging perfluoroalkyl phosphinic acids (PFPiAs) in common carp. The results showed apparent hepatotoxicity in both male and female carp, characterized by cell necrosis, apoptosis, and steatosis. The dysregulation of hepatic lipid metabolism was found to be the underlying mechanism, with inhibited fatty acid oxidation in female carp and enhanced fatty acid uptake in male carp. These changes were more pronounced in male carp, possibly due to the stronger binding capacity of 8:8 PFPiA to nuclear transcription factors mediating lipid metabolism and inflammation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
