Article
Biochemistry & Molecular Biology
Yixuan Bai, Ziqi Zeng, Zhiyong Xie, Guijie Chen, Dan Chen, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: In this study, the immunosuppressant model in mice was established using cyclophosphamide (Cy), and the regulatory effects of polysaccharides from Fuzhuan brick tea (FBTPSs) on the immune function and gut microbiota of mice were investigated. The results showed that FBTPSs restored the levels of body weight, feed intake, immune organ index, cytokine, and immunoglobulin A in mice, as well as the injured gut caused by Cy. Furthermore, FBTPSs significantly modulated the gut microbiota and the gut microbiota-derived short-chain fatty acids might play a role in improving immune function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Xiaojie Lu, Yue Jing, Naisheng Zhang, Yongguo Cao
Summary: Killed Eurotium cristatum and its polysaccharides can alleviate ulcerative colitis by modulating gut dysbiosis, improving intestinal inflammation, and tight junction protein levels.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Wuqi Yang, Daoyuan Ren, Yan Zhao, Lei Liu, Xingbin Yang
Summary: The study found that Fuzhuanbrick tea polysaccharide has a protective effect in a mouse model of dextran sulfate sodium-induced ulcerative colitis, and can alleviate the disease through regulating intestinal flora, promoting microbial metabolism, and repairing intestinal barrier.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Guijie Chen, Yixun Bai, Ziqi Zeng, Yujia Peng, Wangting Zhou, Wenbiao Shen, Xiaoxiong Zeng, Zhonghua Liu
Summary: The polysaccharide fraction FBTPS-2-1 extracted from Fuzhuan brick tea showed potential immunostimulatory activity, enhancing phagocytosis of macrophages and promoting the secretion of inflammatory cytokines. This indicates that FBTPS-2-1 could be a functional food for improving human health by modulating the host immune reaction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Guijie Chen, Mingjia Wang, Ziqi Zeng, Minhao Xie, Weiqi Xu, Yujia Peng, Wangting Zhou, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: FBTPS-3 can be expected as a novel prebiotic for the treatment of IBD by modulating gut microbiota and promoting the production of short chain fatty acids.
Article
Agriculture, Multidisciplinary
Zhiyong Xie, Ziqi Zeng, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: The intracellular polysaccharides of Aspergilluscristatus (IPSs) from Fuzhuan brick tea have been found to improve immune function and modulate gut microbiota. In this study, it was demonstrated that the purified fraction of IPSs (IPSs-2) can protect against colitis in mice induced by dextran sulfate sodium (DSS) through various mechanisms, including reducing inflammation, repairing intestinal barrier function, and modulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Zhiyong Xie, Yixuan Bai, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: IPSs from Aspergillus cristatus exhibited immunomodulatory activity in vitro and in vivo, boosting immune function, improving intestinal barrier function, and balancing gut microbiota. These results indicate the potential of IPSs as probiotics and immunomodulators for strengthening host immunity and gut health.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ziqi Zeng, Zhiyong Xie, Guijie Chen, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: This study found that both CFBTPS and FBTPS-3 have potential in attenuating colitis induced by DSS in mice, with FBTPS-3 showing a better anti-inflammatory effect than CFBTPS.
Article
Food Science & Technology
Wenjuan Yang, Shirui Cheng, Meng Liu, Nan Li, Jing Wang, Wenbo Yao, Fuxin Chen, Jianwu Xie, Pin Gong
Summary: Tea polysaccharide FTP3 has lipid-lowering effects and can reduce lipid accumulation, activate AMPK, and decrease the expressions of SREBP-1C and FAS proteins.
Article
Food Science & Technology
Guijie Chen, Ziqi Zeng, Minhao Xie, Yujia Peng, Wangting Zhou, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: Polysaccharides from Fuzhuan brick tea, specifically the purified fraction FBTPS-2-1, have probiotic activity and can modulate the structure and metabolic pathways of gut microbiota to promote health.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Yujiao Sun, Fan Wang, Yang Liu, Shuai Liu, Yuye An, Haiyan Xue, Jiankang Wang, Fei Xia, Xuefeng Chen, Yungang Cao
Summary: This study investigated the immune-protective effect of polysaccharides from Fuzhuan brick tea (FBTPs) in immunosuppressive mice. The results showed that FBTPs improved immune responses and reduced oxidative stress in the mice. Microbiota analysis revealed that FBTPs restored microbial dysbiosis and metabolomics analysis found altered metabolites involved in immune responses and energy supply. These findings provide insights into the immune-protective effect of FBTPs on regulating intestinal microbiota and metabolism.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Agriculture, Multidisciplinary
Fang Zhou, Yi-Long Li, Xin Zhang, Kun-Bo Wang, Jian-An Huang, Zhong-Hua Liu, Ming-Zhi Zhu
Summary: The study found that FBTP supplementation effectively reduced obesity in HFD-fed rats by improving intestinal oxidative stress and barrier function, as well as attenuating gut microbiota dysbiosis induced by HFD. Specific core microbes, including Akkermansia muciniphila, Alloprevotella, Bacteroides, and Faecalibaculum, were improved by FBTPs. The antiobesity effect of FBTPs was shown to be dependent on gut microbiota, as demonstrated by a fecal microbiota transplantation experiment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Food Science & Technology
Cui Cao, Zhongfu Wang, Guiping Gong, Wenqi Huang, Linjuan Huang, Shuang Song, Beiwei Zhu
Summary: This review summarizes the extraction, purification, and structural types of Lycium barbarum polysaccharides (LBPs) and their regulatory effects on gut microbiota and their derived metabolites. Furthermore, the health promoting effects of LBPs on host bidirectional immunity and metabolic syndrome by targeting gut microbiota are also discussed based on their structural types.
Article
Food Science & Technology
Xin Li, Yu Zhang, Yanglei Yi, Yuanyuan Shan, Bianfang Liu, Yuan Zhou, Xin Wang, Xin Lu
Summary: The study found that adding Moringa oleifera Lam. leaves to Fuzhuan Brick Tea can increase the content of alkaloids, amino acids, lipids, and enrich microbial communities. This has potential implications for innovation in product development and advancing the tea industry.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Haiping Du, Lin Shi, Qi Wang, Tao Yan, Yu Wang, Xiangnan Zhang, Chengcheng Yang, Yan Zhao, Xingbin Yang
Summary: Polysaccharides extracted from Fu brick tea (FBTP) have antiobesity effects by enhancing fat burning and energy expenditure through modulation of gut microbiota composition and increasing brown adipose tissue development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Food Science & Technology
Guijie Chen, Yujia Peng, Minhao Xie, Weiqi Xu, Chunxu Chen, Xiaoxiong Zeng, Zhonghua Liu
Summary: Fuzhuan brick tea (FBT), a traditional beverage in China's border regions, has gained attention for its unique flavor and various health benefits. Despite this, FBT has received less attention compared to green tea, oolong tea, and black tea. This review highlights the processing, microorganisms, chemical constituents, health benefits, and potential risks associated with FBT. Fungal fermentation plays a key role in the processing of FBT, and the dominant fungal community is identified as Aspergillus cristatus. FBT exhibits diverse biological activities, such as antioxidant, anti-inflammatory, anti-obesity, anti-bacterial, and anti-tumor effects. The potential risks of FBT are also discussed. Overall, this review aims to stimulate further research on FBT.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Zhiyong Xie, Yixuan Bai, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: IPSs from Aspergillus cristatus exhibited immunomodulatory activity in vitro and in vivo, boosting immune function, improving intestinal barrier function, and balancing gut microbiota. These results indicate the potential of IPSs as probiotics and immunomodulators for strengthening host immunity and gut health.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ziqi Zeng, Zhiyong Xie, Guijie Chen, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: This study found that both CFBTPS and FBTPS-3 have potential in attenuating colitis induced by DSS in mice, with FBTPS-3 showing a better anti-inflammatory effect than CFBTPS.
Article
Chemistry, Applied
Xuhui Kan, Yuhang Hu, Yujie Huang, Xia Fan, Guijie Chen, Hong Ye, Xiaoxiong Zeng
Summary: This study prepared a novel emulsifier WPI-GA-C and investigated its effects on human gut microbiota. The results showed that WPI-GA-C-stabilized emulsion could significantly modulate the composition and abundance of gut microbiota, indicating its potential to promote healthy changes in human gut microbiota.
FOOD HYDROCOLLOIDS
(2023)
Article
Agriculture, Multidisciplinary
Yujia Peng, Wei Dong, Guijie Chen, Jia Mi, Lu Lu, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan
Summary: In this study, it was discovered that anthocyanins from Lycium ruthenicum Murray (ACN) effectively improved neuroinflammation induced by a high-fructose diet (HFrD) in mice. ACN enhanced the integrity of the intestinal barrier and suppressed the toll-like receptor 4 (TLR4) signaling pathway to ameliorate neuroinflammation, which was confirmed through Tlr4-/- mice. Furthermore, ACN was able to regulate the dysbiosis of gut microbiota induced by HFrD.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Baoming Tian, Renjian Liu, Tianrui Xu, Ming Cai, Rongliang Mao, Liangshui Huang, Kai Yang, Xiaoxiong Zeng, Sun Peilong
Summary: This study investigated the effects of Hericium erinaceus polysaccharides (HEP) on immunoregulation and gut microbiota (GM) in cyclophosphamide (CTX)-treated mice. The results showed that HEP improved immune function and GM dysregulation caused by CTX. In addition, HEP increased the abundance of short-chain fatty acid (SCFA)-producing bacteria and enhanced the TLR4/NF-kappa B pathway.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Correction
Medicine, Research & Experimental
Mingfu Niu, Shumao Chai, Xiaoyan You, Wenhui Wang, Cuili Qin, Qiang Gong, Tingting Zhang, Peng Wan
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Zhiyong Xie, Ziqi Zeng, Guijie Chen, Wei Dong, Yujia Peng, Weiqi Xu, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Summary: The intracellular polysaccharides of Aspergilluscristatus (IPSs) from Fuzhuan brick tea have been found to improve immune function and modulate gut microbiota. In this study, it was demonstrated that the purified fraction of IPSs (IPSs-2) can protect against colitis in mice induced by dextran sulfate sodium (DSS) through various mechanisms, including reducing inflammation, repairing intestinal barrier function, and modulating gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Chunxu Chen, Tianhui Li, Guijie Chen, Dan Chen, Yujia Peng, Bing Hu, Yi Sun, Xiaoxiong Zeng
Summary: Sialylated IgG is a glycoprotein in breast milk with anti-inflammatory properties. Previous research has shown that sialylated IgG can promote the growth of Bifidobacterium in the gut microbiota of healthy individuals. This study investigated the prebiotic effect of sialylated IgG on the gut microbiota of patients with inflammatory bowel disease (IBD) through in vitro fermentation.
Article
Food Science & Technology
Xianghui Kong, Weiqi Xu, Kaixin Zhang, Guijie Chen, Xiaoxiong Zeng
Summary: This study aimed to investigate the catechin conversion and enzymatic synthesis of TFs and TSs using PPO from potato tuber. The results showed that temperature, pH, and duration significantly influenced the conversion of catechins and formation of TFs and TSs. Most of catechin substrates were consumed within 60-90 minutes of the reaction, resulting in high amounts of TFs and TSs. TSs content was significantly higher than TFs, with TSs reaching over three times the maximum content of TFs. Lower temperature favored the production of dimers, especially TFs. Higher pH led to higher catechin consumption and TSs content, while TFs reached their maximum content at pH 5.0. These findings provide a theoretical basis and practical guidance for the targeted processing of tea catechin dimers in vitro.
Article
Food Science & Technology
Peng Wan, Han Liu, Yuanyuan Zhu, Haitao Xin, Yanli Ma, Zhizhou Chen
Summary: The study aimed to investigate the effects of Polygonatum sibiricum on microbial fermentation, physicochemical properties, and functional properties of fermented soymilk. It was found that the addition of P. sibiricum and P. sibiricum polysaccharides significantly promoted fermentation, improved product stability, and enhanced functional components such as antioxidants.
Article
Food Science & Technology
Zhixian Li, Zhuqing Dai, Enjuan Shi, Peng Wan, Guijie Chen, Zhongyuan Zhang, Yayuan Xu, Ruichang Gao, Xiaoxiong Zeng, Dajing Li
Summary: This study used an in vitro fermentation model to explore the interaction between β-carotene and gut microflora. The results showed that gut microflora can metabolize β-carotene into retinol (VA) and β-carotene also influences the production of short-chain fatty acids (SCFAs) and the structure and composition of gut microflora.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Chemistry, Applied
Xuhui Kan, Zhuqing Dai, Dan Chen, Xiaoxiong Zeng, Xia Fan
Summary: This study investigated the potential of whey protein isolate-gum Arabic Maillard conjugates (WPIGA-C) as emulsifiers for stabilizing high internal phase emulsions (HIPEs) and preparing HIPEs with improved properties for personalized functional foods and 3D printing. The results showed that the concentration of WPIGA-C and oil mass fraction had significant effects on the properties of HIPEs. HIPEs stabilized with 3% WPIGA-C and 80% oil mass fraction exhibited better properties compared to lower concentrations of WPIGA-C and oil mass fractions. WPIGA-C could be used to prepare stable HIPEs as potential inks for 3D printing.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Wangting Zhou, Peiyun Liu, Weiqi Xu, Linwu Ran, Yamei Yan, Lu Lu, Xiaoxiong Zeng, Youlong Cao, Jia Mi
Summary: Polysaccharides from Lycium barbarum (LBPs-4) can improve glucose metabolism and intestinal barrier function by enhancing the integrity of the intestinal barrier and modulating the composition of the gut microbiota. This suggests that LBPs-4 has potential as a prebiotic for improving glucose metabolism and gut health.
Article
Food Science & Technology
Yang Yang, Shan Xu, Kemeng Yang, Yuning Sun, Ruirui Yang, Yanan Hu, Guijie Chen, Huimei Cai
Summary: This study characterized the composition of terpenoids, particularly triterpene saponins, in forest-grown wild American ginseng. The results showed that the predominant active components were American ginseng ginsenosides (AGGs), which exhibited potent antioxidant capabilities and anti-inflammatory effects. These findings suggest that AGG-rich forest-grown wild American ginseng has the potential to improve human health.