Article
Environmental Sciences
Wantang Huang, Hua Yin, Yuanyu Yang, Lizhu Jin, Guining Lu, Zhi Dang
Summary: This study demonstrated that both PEMPs and TBBPA have detrimental effects on Caco-2 cells, with TBBPA playing a major role and high concentrations of PEMPs also affecting cell viability. TBBPA selectively inhibits the growth of gram-positive bacteria, leading to shifts in microbiota composition that are unfavorable for gut health. The interference of PEMPs and TBBPA also alters metabolism pathways of gut microbiota, highlighting the potential threat to human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Plant Sciences
Julia Hankel, Bussarakam Chuppava, Volker Wilke, Clara Berenike Hartung, Uthayakumar Muthukumarasamy, Till Strowig, Knud Erik Bach Knudsen, Josef Kamphues, Christian Visscher
Summary: The study found that high levels of rye in the diet can affect the composition of gut microbiota in pigs, promoting the growth of beneficial bacteria while inhibiting the growth of the foodborne pathogen Salmonella Typhimurium.
Article
Chemistry, Applied
Qixing Nie, Jielun Hu, Haihong Chen, Fang Geng, Shaoping Nie
Summary: The study suggests that arabinoxylan has positive effects on the gut microbiota and metabolites in type 2 diabetic rats, promoting the growth of fiber-degrading bacteria, reducing the abundance of opportunistic pathogens, and modulating the levels of metabolites.
Article
Microbiology
Zhongxia Li, Huibin Zhang, Li He, Yaqin Hou, Yingjuan Che, Tian Liu, Shaobai Xiong, Xuguang Zhang, Shunjing Luo, Chengmei Liu, Tingting Chen
Summary: Arabinoxylan (AX) from rice bran and corn bran have different structural features and show different effects on gut microbiota and health. Rice bran AX and deferulyolated rice bran AX have lower gas and total short-chain fatty acid (SCFA) production, but higher butyrate production compared to corn bran AX and deferulyolated corn bran AX.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Applied
Xiaowei Zhang, Jianhua Xie, Tingting Chen, Dongdong Ma, Tianming Yao, Fangting Gu, Jongbin Lim, Mitchell R. Tuinstra, Bruce R. Hamaker
Summary: The study reveals a high specificity of fiber structure to gut bacteria use and short chain fatty acid production, with different genotype-specific effects on gut microbiota and SCFA profiles.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Hitesh P. Gelli, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
Summary: Using cell-penetrating peptides (CPPs) is an effective strategy to improve drug absorption. Among the 9 most promising CPPs studied, 4 of them significantly increased the paracellular permeability of the intestinal barrier without compromising cellular health. Furthermore, these 4 CPPs also affected the growth of the majority of tested commensal strains.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Haidi Xu, Bradley L. Reuhs, Thaisa M. Cantu-Jungles, Yunus E. Tuncil, Amandeep Kaur, Anton Terekhov, Eric C. Martens, Bruce R. Hamaker
Summary: This study investigated the relationship between fine structure and fermentability of Corn arabinoxylan (CAX) by the human gut microbiota. The analysis revealed an organized structural feature of CAX, with complex branching patterns. Contrary to conventional views, smaller fiber structures with higher branch complexity fermented slower.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Hong Yao, Shiyi Lu, Barbara A. Williams, Bernadine M. Flanagan, Michael J. Gidley, Deirdre Mikkelsen
Summary: This study compared relative and absolute abundance datasets to investigate the alterations of human fecal microbiota during in vitro fermentation of different types of dietary fiber. The results showed that the DF mixtures more efficiently supported microbial growth than individual components, and the absolute abundance data positively correlated with butyrate production.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Yi Cheng, Chie Watanabe, Yusuke Ando, Satoshi Kitaoka, Yuya Egawa, Tomoya Takashima, Akihiro Matsumoto, Masahiro Murakami
Summary: In this study, researchers developed a partially laminated cell culture model to simulate the mucus layer in the human intestines. Compared to traditional coculture models, this partially laminated model maintained a higher barrier function and adjustable permeability according to the cell ratio. This novel model may have potential applications in vitro for evaluating intestinal mucosal permeability and drug efficacy.
Article
Chemistry, Applied
Hong Yao, Bernadine M. Flanagan, Barbara A. Williams, Munirah Ismail, Astrada Dyna Ersya, Michael J. Gidley, Deirdre Mikkelsen
Summary: This study investigated the fermentability of wheat arabinoxylan before and after hydrolysis by selective enzymes, and found that lower arabinose-to-xylose ratios and lower di-substitution levels contributed to slower substrate disappearance but higher microbial diversity. The structure of arabinoxylan also affected microbial beta diversity, with different genera associated with enzymatically-modified samples. Gas kinetics and end-product analyses showed that gas production rates depended on the ratio and substitution patterns, and faster fermentation rates resulted in different proportions of propionate, acetate, and butyrate. Overall, this study reveals the potential link between microbial arabinoxylan degraders and fermentation outcomes specific to the fine structures of arabinoxylan.
FOOD HYDROCOLLOIDS
(2023)
Article
Food Science & Technology
Verica Takac, Viola Toth, Marianna Rakszegi, Peter Miko, Sanja Mikic, Milan Mirosavljevic
Summary: An increase in the production and consumption of spelt products can have positive effects on human health due to the presence of bioactive compounds in the grain. The success of spelt wheat in organic farming may be attributed to its hulled nature, which provides protection against environmental stress factors and reduces the need for chemical protection. This study investigated the variations in bioactive compounds, protein, starch, and fructan content in bread and spelt wheat under different farming systems. Results showed that spelt wheat had higher protein and alkylresorcinol content but lower fructan content compared to conventional wheat. Organic spelt had higher starch, fiber, and alkylresorcinol content but lower beta-glucan and protein content than conventionally grown spelt. The environmental conditions, farming systems, and wheat species contributed to the variations in compositional traits.
Article
Chemistry, Applied
Yan-Hong Shi, Jin-Jing Xiao, Yu-Ying Liu, Ya-Jing Deng, Wen-Zhe Feng, Dong Wei, Min Liao, Hai-Qun Cao
Summary: Limited research has been conducted on the effects of human gut microbiota on the oral bioaccessibility and intestinal absorption of pesticide residues in food. This study found that gut microbiota play a dual role in contaminant release and metabolism, with Lactobacillus plantarum being a key bacterial species that significantly influences pesticide stability. The addition of L. plantarum to the system can reduce the relative amounts of pesticides, and the interaction between the food matrix and human gut microbiota leads to different absorption rates, with barrier effects increasing over time.
Article
Pharmacology & Pharmacy
Yuan-Feng Zou, Cen-Yu Li, Yu-Ping Fu, Xin Feng, Xi Peng, Bin Feng, Li-Xia Li, Ren-Yong Jia, Chao Huang, Xu Song, Cheng Lv, Gang Ye, Ling Zhao, Yang-Ping Li, Xing-Hong Zhao, Li-Zi Yin, Zhong-Qiong Yin
Summary: In this study, an inulin (CPPF) from Codonopsis pilosula was shown to have potential prebiotic activity in vitro. Using an immunosuppressed mouse model, the researchers investigated the effects of CPPF on the intestinal mucosa and microbiota after oral administration. The results demonstrated that CPPF improved the secretion of sIgA and Muc2 in the ileum, and also exhibited anti-inflammatory activities in different parts of the intestine. High-throughput sequencing analysis of the 16S rRNA V4 region revealed that CPPF modulated the relative abundance of certain bacteria, indicating its role in restoring gut microbiota. Overall, this study suggests that CPPF, as a medicinal prebiotic, has immunomodulatory, anti-inflammatory, and gut microbiota modulatory activities.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Ji Wang, Huanbing Tian, Yongpeng Shi, Ying Yang, Feifei Yu, Hanwen Cao, Lan Gao, Mingxin Liu
Summary: This study investigates the impact of selective oxidation on polyethylene microplastics (LDPE-MPs) and their toxic effects on animals and cells. The results show that oxidized LDPE-MPs cause more severe intestinal damage, oxidative stress, and inflammatory response. Additionally, the oxidized microplastics are more prone to accumulate in cells and induce cell damage and mitochondrial dysfunction.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Microbiology
Hideaki Takahashi, Tadashi Fujii, Saki Yamakawa, Chikako Yamada, Kotoyo Fujiki, Nobuhiro Kondo, Kohei Funasaka, Yoshiki Hirooka, Takumi Tochio
Summary: The combined intake of short fructan (1-kestose) and long fructan (inulin) has been found to be more effective in preventing food allergies compared to single intake, indicating that they have different allergy-preventive mechanisms. This suggests that the combined intake of these fructans may have a beneficial effect in preventing allergies.
Article
Geriatrics & Gerontology
R. Filip, S. Possemiers, A. Heyerick, I. Pinheiro, G. Raszewski, M. -J. Davicco, V. Coxam
JOURNAL OF NUTRITION HEALTH & AGING
(2015)
Article
Cell Biology
Sarah Devriese, Lien Van den Bossche, Sophie Van Welden, Tom Holvoet, Iris Pinheiro, Pieter Hindryckx, Martine De Vos, Debby Laukens
HISTOCHEMISTRY AND CELL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Iris Pinheiro, Lien Dejager, Claude Libert
Article
Microbiology
Massimo Marzorati, Barbara Vanhoecke, Tine De Ryck, Mehdi Sadaghian Sadabad, Iris Pinheiro, Sam Possemiers, Pieter Van den Abbeele, Lara Derycke, Marc Bracke, Jan Pieters, Tom Hennebel, Hermie J. Harmsen, Willy Verstraete, Tom Van de Wiele
Article
Medicine, Research & Experimental
Iris Pinheiro, Lien Dejager, Ioanna Petta, Sofie Vandevyver, Leen Puimege, Tina Mahieu, Marlies Ballegeer, Filip Van Hauwermeiren, Carlo Riccardi, Marnik Vuylsteke, Claude Libert
EMBO MOLECULAR MEDICINE
(2013)
Article
Immunology
Lien Dejager, Iris Pinheiro, Pieter Bogaert, Liesbeth Huys, Claude Libert
INFECTION AND IMMUNITY
(2010)
Article
Agriculture, Multidisciplinary
Sam Possemiers, Iris Pinheiro, An Verhelst, Pieter Van den Abbeele, Lois Maignien, Debby Laukens, Stuart G. Reeves, Larry E. Robinson, Thomas Raas, Yves-Jacques Schneider, Tom Van de Wiele, Massimo Marzorati
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Tom Van Bogaert, Sofie Vandevyver, Lien Dejager, Filip Van Hauwermeiren, Iris Pinheiro, Ioanna Petta, David Engblom, Anna Kleyman, Guenther Schuetz, Jan Tuckermann, Claude Libert
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Review
Biochemistry & Molecular Biology
Lien Dejager, Iris Pinheiro, Eline Dejonckheere, Claude Libert
TRENDS IN MICROBIOLOGY
(2011)
Article
Nutrition & Dietetics
Christiane Laue, Yala Stevens, Monique van Erp, Ekaterina Papazova, Edlyn Soeth, Angelika Pannenbeckers, Ellen Stolte, Ruwen Boehm, Sophie Le Gall, Xavier Falourd, Simon Ballance, Svein H. Knutsen, Iris Pinheiro, Sam Possemiers, Paul M. Ryan, R. Paul Ross, Catherine Stanton, Jerry M. Wells, Sylvie van der Werf, Jurriaan J. Mes, Juergen Schrezenmeir
Summary: This study investigated the potential of non-digestible polysaccharide (NPS) preparations to enhance immune response in aged individuals. Results suggest that arabinoxylan (AX) may enhance influenza vaccine efficacy and reduce the incidence of common colds. Further research is warranted to explore AX as an oral adjuvant for vaccine support.
Article
Nutrition & Dietetics
Yala Stevens, Tessa de Bie, Iris Pinheiro, Montserrat Elizalde, Ad Masclee, Daisy Jonkers
Summary: Citrus flavonoids and their metabolites have beneficial effects on intestinal barrier function and inflammation by reducing NF-kappa B activity.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Iris Pinheiro, Aurora Barbera, Imma Raurell, Federico Estrella, Marcel de Leeuw, Selin Bolca, Davide Gottardi, Nigel Horscroft, Sam Possemiers, Maria Teresa Salcedo, Joan Genesca, Maria Martell, Salvador Augustin
Summary: The present study demonstrated that oral administration of a specific bacterial consortium improved disease outcomes in two rodent models of non-alcoholic fatty liver disease. The consortium was found to effectively replace and enrich the gut microbiome, leading to improvements in endothelial function, fibrosis, and disease progression.
Article
Integrative & Complementary Medicine
Iris Pinheiro, Larry Robinson, An Verhelst, Massimo Marzorati, Bjorn Winkens, Pieter van den Abbeele, Sam Possemiers
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2017)
Review
Immunology
Claude Libert, Lien Dejager, Iris Pinheiro
NATURE REVIEWS IMMUNOLOGY
(2010)