Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Sara Jimenez-Fernandez, Manuel Gurpegui, Daniel Garrote-Rojas, Luis Gutierrez-Rojas, Maria D. Carretero, Christoph U. Correll
Summary: This study aimed to investigate the differences in oxidative stress markers and antioxidants between patients with bipolar depression and unipolar depression. The results showed that both bipolar depression and unipolar depression may be associated with an impaired oxidative stress balance, with significantly higher uric acid levels observed in unipolar depression compared to bipolar depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Chengcheng Zhang, Peiyan Ni, Sugai Liang, Xiaojing Li, Yang Tian, Xiangdong Du, Wei Wei, Yajing Meng, Jinxue Wei, Xiaohong Ma, Wei Deng, Wanjun Guo, Mingli Li, Hua Yu, Liansheng Zhao, Qiang Wang, Sham C. Pak, Tao Li
Summary: Patients with bipolar depression or unipolar depression shared gray matter volume abnormalities in the right thalamus. The PER3 and CRY2 genes may play critical roles in right hippocampal dysfunction in bipolar depression and right thalamic dysfunction in unipolar depression, respectively. These findings provide potential molecular targets for the treatment of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Sara Poletti, Benedetta Vai, Mario Gennaro Mazza, Raffaella Zanardi, Cristina Lorenzi, Federico Calesella, Silvia Cazzetta, Igor Branchi, Cristina Colombo, Roberto Furlan, Francesco Benedetti
Summary: This study successfully predicted the differential diagnosis of MDD and BD by considering plasma levels of cytokines, chemokines, and growth factors, and found that the immune-inflammatory signature is key in distinguishing between the two disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Behavioral Sciences
Rosario Aronica, Paolo Enrico, Letizia Squarcina, Paolo Brambilla, Giuseppe Delvecchio
Summary: Studies have found a correlation between immunomarkers and white matter alterations in patients with depressive disorders, providing new insights for diagnosis and treatment of these disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Diana Bogdanova
Summary: Recent studies compare psychomotor reactivity disorders and gait activity in unipolar and bipolar depression, and find significant differences among the three groups. Bipolar patients exhibit more inhibited psychomotor skills than unipolar patients and healthy controls. The simplified variant of the equilibriometric task is the most sensitive and psychomotor reactivity is a more precise marker than psychomotor activity. These findings are important for distinguishing similar psychiatric conditions and developing new diagnostic and therapeutic approaches.
Article
Psychology, Multidisciplinary
Ma Ruihua, Zhao Meng, Chen Nan, Liu Panqi, Guo Hua, Liu Sijia, Shi Jing, Zhao Ke, Tan Yunlong, Tan Shuping, Yang Fude, Tian Li, Wang Zhiren
Summary: This study aimed to investigate differences in facial emotion recognition among patients with UD, BD, and normal controls. It found that UD patients performed poorly in recognizing negative expressions and had longer recognition times, while BD patients had lower accuracy in recognizing positive expressions and longer recognition times. Rapid facial expression recognition may serve as a potential endophenotype for early identification of unipolar and BD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Laura Orsolini, Leonardo Ricci, Simone Pompili, Angelica Cicolini, Umberto Volpe
Summary: The aim of this study was to evaluate the baseline hsCRP levels in inpatients with unipolar and bipolar depression and their relationship with psychopathological, temperamental, and chronotype features. Results showed that previous suicide attempt, death, and self-harm/self-injury thoughts were significantly associated with higher hsCRP levels. Linear regression analysis revealed that higher scores on the depressive affective temperament and lower scores on the hyperthymic and irritable affective temperaments, as well as lower MEQ scores, predicted higher hsCRP levels.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study developed a new measure for identifying bipolar disorder, comparing the classification accuracy of a weighting rating scale with equivalent weightings for each item. Results showed that both methods had extremely high classificatory accuracy, and identified optimal cut-off scores for diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Sandeep Grover, Himani Adarsh
Summary: This study aimed to evaluate the prevalence of mixed specifier in patients with unipolar and bipolar depression in India. The results showed that about one-fifth of patients with both types of depression exhibited mixed features during the acute phase of the illness, with no significant difference in the prevalence between the two groups.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Shuqi Kong, Zhiang Niu, Dongbin Lyu, Lvchun Cui, Xiaohui Wu, Lu Yang, Hong Qiu, Wenjie Gu, Yiru Fang
Summary: This study investigates the seasonal symptoms and non-enzymatic oxidative stress in first hospitalized patients with bipolar and unipolar depression, aiming to differentiate between the two disorders and reduce misdiagnosis. The study finds that patients with bipolar depression have distinct seasonal characteristics compared to those with unipolar depression. Clinical symptoms and indicators of oxidative stress may serve as factors for distinguishing between seasonal unipolar depression and bipolar depression. Young individuals aged 15-35 are more likely to develop bipolar depression in winter.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
HaoFei Wang, Shui Tian, Rui Yan, Hao Tang, Jiabo Shi, RongXin Zhu, Yu Chen, YingLin Han, Zhilu Chen, HongLiang Zhou, Shuai Zhao, ZhiJian Yao, Qing Lu
Summary: This study investigated the neural oscillation patterns and cognitive impairments in patients with unipolar depression (UD) and bipolar depression (BD) using magnetoencephalography (MEG). The results showed that BD patients had more severe cognitive impairments in different dimensions compared to UD patients, and these impairments were associated with disrupted beta power modulations.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Ibrahim H. Aslan, David S. Baldwin
Summary: The study found that patients with unipolar depression showed higher levels of rumination and performed better in some neuropsychological tests compared to those with bipolar depression. There was no significant difference in rumination between the two depression groups when duration of illness was controlled. A negative relationship was observed between rumination and emotion regulation as well as psychological resilience in both patient groups, but not in healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Sophie Leclercq, Markus Schwarz, Nathalie M. Delzenne, Peter Starkel, Philippe de Timary
Summary: The gut-brain communication in patients with alcohol use disorder involves complex interactions between immune, metabolic and neural pathways. The study found that neurotoxic metabolite quinolinic acid increased and neuroprotective metabolite kynurenic acid decreased in AUD patients, particularly at the end of a detoxification program. Inflammatory marker hsCRP was associated with metabolic ratios of the kynurenine pathway, while tryptophan, KYNA and QUIN were correlated with depression, alcohol craving and reaction time, respectively.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychiatry
Donato Favale, Maria Nacci, Antonello Bellomo, Julio Torales, Joao Mauricio Casltadelli-Maia, Antonio Ventriglio
Summary: This study found that patients with bipolar depression showed higher levels of psychopathological issues, depressive and anxious symptoms, and suicidality compared to patients with unipolar depression. They also had lower levels of hope and resilience, which were positively correlated with each other and inversely correlated with psychopathology, depressive symptoms, and suicidal symptoms. Therefore, specific psycho-educational and psychotherapeutic interventions should be promoted to increase levels of hope and resilience in mood disorders, especially in bipolar depression.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Melvin G. McInnis, Ole A. Andreassen, Ana C. Andreazza, Uri Alon, Michael Berk, Teri Brister, Katherine E. Burdick, Donghong Cui, Mark Frye, Marion Leboyer, Philip B. Mitchell, Kathleen Merikangas, Andrew A. Nierenberg, John Nurnberger, Daniel Pham, Eduard Vieta, Lakshmi N. Yatham, Allan H. Young
Summary: Bipolar disorder is a complex condition with onset in late adolescence, complicated by comorbid medical and psychiatric disorders. The etiology and reliable biological markers remain unknown, suggesting the need for large-scale global longitudinal studies to determine causes and improve treatment.
Article
Multidisciplinary Sciences
Emmalin Buajitti, Laura C. Rosella, Ersi Zabzuni, L. Trevor Young, Ana C. Andreazza
Summary: This study used administrative data from Ontario, Canada to measure the prevalence, patient characteristics, and healthcare costs of mitochondrial disease, showing a prevalence rate of 1 in 3989. The findings highlight the high healthcare burden and costs incurred by patients with mitochondrial disease in the Ontario healthcare system.
Article
Medicine, General & Internal
Stephen J. Suss, Anna Manelis, Joao Paulo Lima Santos, Cynthia L. Holland, Richelle S. Stiffler, Hannah B. Bitzer, Sarrah Mailliard, Madelyn Shaffer, Kaitlin Caviston, Michael W. Collins, Mary L. Phillips, Anthony P. Kontos, Amelia Versace
Summary: Concussion among adolescents is a public health concern, and the differences in brain function between adolescents with and without a history of concussion are not well understood. This study used resting state functional magnetic resonance imaging (fMRI) to investigate these differences and found disrupted functional connectivity between the hippocampal network and the right inferior frontal gyrus in adolescents with concussion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Manuel Gardea-Resendez, Stacey J. Winham, Francisco Romo-Nava, Alfredo Cuellar-Barboza, Matthew M. Clark, Ana Cristina Andreazza, Alejandra Cabello-Arreola, Marin Veldic, David J. Bond, Balwinder Singh, Miguel L. Prieto, Nicolas A. Nunez, Hannah Betcher, Katherine M. Moore, Thomas Blom, Colin Colby, Richard S. Pendegraft, Sydney S. Kelpin, Aysegul Ozerdem, Alessandro Miola, Eleanna De Filippis, Joanna M. Biernacka, Susan L. McElroy, Mark A. Frye
Summary: This study aims to assess diet quality in bipolar disorder patients and find associations between unhealthy diet quality and depression, obesity, and cardiometabolic abnormalities. These associations were found to be stronger in female participants.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Kritleen K. Bawa, Joycelyn Ba, Alex Kiss, RuoDing Wang, Vivian Feng, Walter Swardfager, Ana Andreazza, Damien Gallagher, Giovanni Marotta, Nathan Herrmann, Krista L. Lanctot
Summary: This study investigates the relationship between lipid peroxidation, apathy, and executive dysfunction in patients at risk for VCI. The results suggest that lipid peroxidation may play an important role in the co-occurrence of apathy and executive dysfunction in those at risk for VCI.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, General & Internal
Joao Paulo Lima Santos, Michele Bertocci, Genna Bebko, Tina Goldstein, Tae Kim, Satish Iyengar, Lisa Bonar, MaryKay Gill, John Merranko, Anastasia Yendiki, Boris Birmaher, Mary L. Phillips, Amelia Versace
Summary: Diffusion Magnetic Resonance Imaging (dMRI) studies have found abnormalities in emotion regulation circuits in patients with early-onset bipolar disorder (BD), and this study aims to examine the contribution of previous illness and its neural correlates. The results show that a higher number of depressive episodes during childhood/adolescence and higher percentage of time with syndromic depression were associated with lower fractional anisotropy (FA) in certain brain regions. Lower FA in these regions was also correlated with higher depressive and anxiety symptoms. Interestingly, higher FA in certain brain regions was protective against the recurrence of depressive episodes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Vivian Feng, Shankar Tumati, Ruoding Wang, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Susan Marzolini, Paul Oh, Ana Andreazza, Krista L. Lanctot
Summary: This study found that markers of late-stage lipid peroxidation are elevated in coronary artery disease patients with poor sleep and are associated with daily disturbances. However, this association is not related to other factors or with sleep quality and its factors after exercise intervention.
Article
Cardiac & Cardiovascular Systems
Etienne Abdelnour-Berchtold, Aadil Ali, Cristina Baciu, Erika L. Beroncal, Aizhou Wang, Olivia Hough, Mitsuaki Kawashima, Manyin Chen, Yu Zhang, Mingyao Liu, Tom Waddell, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: Injured donor lungs stored at 10℃ demonstrated superior oxygenation and protective effects compared to the current clinical standard of 4℃ storage.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Medicine, Research & Experimental
Timofei Chernega, Jaehyoung Choi, Leonardo Salmena, Ana Cristina Andreazza
Summary: This article investigates the current treatment options for mitochondrial diseases and explores the potential of RNA-based therapeutic strategies, including the use of ASOs and RNAi drugs, allotopic therapies, and RNA-based antigenomic therapies. Furthermore, various mechanisms for delivering RNA therapeutic agents to the mitochondrial matrix are reviewed.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Medicine, General & Internal
Aadil Ali, Antti I. Nykanen, Erika Beroncal, Edson Brambate, Andrea Mariscal, Vinicius Michaelsen, Aizhou Wang, Mitsuaki Kawashima, Rafaela V. P. Ribeiro, Yu Zhang, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Summary: This study demonstrates for the first time the feasibility of three-day lung preservation, leading to excellent early post-transplant outcomes. The combination of cold storage and intermittent ex vivo lung perfusion opens up new opportunities in organ transplantation.
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Antoine Lefrere, Guillaume Auzias, Pauline Favre, Irene Kaltenmark, Josselin Houenou, Camille Piguet, Mircea Polosan, Lisa T. Eyler, Mary L. Phillips, Amelia Versace, Michele Wessa, Colm McDonald, Dara M. Cannon, Paolo Brambilla, Marcella Bellani, Christine Deruelle, Raoul Belzeaux
Summary: This study explores the cortical folding in relation to neuro-developmental disorders, focusing on a neurodevelopmental subtype of bipolar disorders (BD-ND). It finds that BD-ND is associated with specific brain morphology revealed by the analysis of sulcal pits, suggesting potential insights into the neurodevelopment process and stratification of patients based on pathophysiological hypothesis.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell & Tissue Engineering
David F. Bodenstein, Pavel Powlowski, Kassandra A. Zachos, Dana El Soufi El Sabbagh, Hyunjin Jeong, Liliana Attisano, Landon Edgar, Douglas C. Wallace, Ana Cristina Andreazza
Summary: Mitochondrial dysfunction is related to various diseases, and autologous mitochondrial transplantation is a potential approach for treating mitochondrial dysfunction. The use of a 5-μm filter B provides high-quality and pure mitochondria for isolation.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Neurosciences
Angela Duong, Hyunjin Jeong, Dana El Soufi El Sabbagh, Ana C. Andreazza
Summary: On March 11, 2020, the World Health Organization declared the outbreak of SARS-CoV-2 as a global pandemic. In patients with SARS-CoV-2, inflammatory markers such as interleukin 6 and C-reactive protein are consistently elevated. This study investigates whether psychiatric patients with preexisting elevated interleukin 6 and C-reactive protein are more susceptible to severe COVID-19 complications.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Meeting Abstract
Neurosciences
Layla Banihashemi, Vanessa Schmithorst, Michele Bertocci, Alyssa Samolyk, Joao P. Lima Santos, Amelia Versace, Megan Taylor, Gabrielle English, Jessie B. Northrup, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison Hipwell, Mary Phillips
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
