Article
Microbiology
Jie Wang, Kun-Te Shang, Qiong-Hong Ma, Zhao-Ying Dong, Yi-Hong Chen, Yu-Feng Yao
Summary: This study aimed to determine whether HSV-1 can be transmitted through TNTs and to investigate the effect of inhibiting the Arp2/3 complex on the intercellular transmission of HSV-1. The results showed that HSV-1 can be transmitted through TNTs and that inhibiting the Arp2/3 complex reduces the number of TNTs and the spread of HSV-1. This finding provides new insights into the transmission mode of HSV-1 and suggests a potential new antiviral target.
Review
Microbiology
Diana di Filippo Villa, Maria-Cristina Navas
Summary: Hepatitis B virus (HBV) infection is a significant global public health issue, affecting approximately 296 million people chronically. Vertical transmission is a common route in endemic areas. Prevention strategies include antiviral treatment during the third trimester of pregnancy, immunoprophylaxis to newborns with HBIG and HBV vaccine. However, up to 30% of infants born to HBeAg-positive mothers and/or with high viral load may experience immunoprophylaxis failure. Therefore, effective management and prevention of HBV vertical transmission are crucial.
Article
Obstetrics & Gynecology
Wafaa Ali Belail Hammad, Justin C. Konje
Summary: Herpes Simplex virus (HSV) infection is common among women of reproductive age, with a risk of vertical transmission to the fetus during pregnancy. Pregnant women with active lesions or asymptomatic shedding are at high risk of vertical transmission during labor, potentially leading to severe consequences in neonates.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Oncology
Hayle Scanlan, Zachary Coffman, Jeffrey Bettencourt, Timothy Shipley, Debra E. Bramblett
Summary: This review provides an overview of HSV-1 as an oncolytic virus candidate and the genomic organization of T-VEC. The advantages and limitations of T-VEC compared to other HSV-1 oncolytic virus variants currently in clinical trials are discussed. Additionally, future directions for the use of HSV-1 oncolytic viruses as cancer therapy are explored.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gabrielle Pageau, Marianne Levasseur, Teresa Paniconi, Eric Jubinville, Valerie Goulet-Beaulieu, Guy Boivin, Julie Jean
Summary: This study investigated the persistence of HSV-1 on surfaces and in food, suggesting that sharing food with infected carriers may pose certain risks.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Virology
Jun Wang, Ke Wu, Longquan Ni, Chenxuan Li, Ruoyan Peng, Yi Li, Zhaojun Fan, Feifei Yin, Fei Deng, Shu Shen, Xiaoli Wu
Summary: This study evaluated the impact of membrane protein genes US7 and UL56 on cell-to-cell spread of HSV-1. The results showed that US7 knockout inhibits viral cell-to-cell spread, and the US7 protein of HB94 strain promotes cell-to-cell spread compared to that of HN19 strain. UL56 knockout does not affect plaque size and syncytium formation, but the gene product of UL56 from the HN19 strain inhibits plaque formation and membrane infusion.
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Letter
Medicine, General & Internal
Charles-Edouard Luyt, David Hajage, Sonia Burrel, Sami Hraiech, Mamadou Hassimiou Diallo, Laurent Papazian, David Boutolleau
Summary: This analysis investigated the efficacy of acyclovir in preventing oropharyngeal HSV reactivation among mechanically ventilated patients.
Review
Pharmacology & Pharmacy
Manisha Pandey, Hira Choudhury, Azila Abdul-Aziz, Subrat Kumar Bhattamisra, Bapi Gorain, Jocelyn Sziou Ting Su, Choo Leey Tan, Woon Yee Chin, Khar Yee Yip
Summary: Eyes are vulnerable to various ailments, with corneal infection by herpes simplex viruses being a prevalent yet serious cause of blindness globally. Novel drug delivery systems, including nanocarriers, prodrugs, and peptides, play a vital role in improving therapeutic efficacy and patient convenience in the treatment of ocular herpes infections.
Article
Virology
Mashidur Rana, Mizumi Setia, Pratima K. Suvas, Anish Chakraborty, Susmit Suvas
Summary: Reactive oxygen species (ROS) play a crucial role in herpes stromal keratitis (HSK), with neutrophils being the primary cells responsible for ROS generation. NOX2 is involved in ROS production in neutrophils. However, manipulating ROS levels in neutrophils may help alleviate the severity of HSK, and NOX2 is not the main contributor to ROS generation in neutrophils.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Integrative & Complementary Medicine
Keyal Uma, Xin Huang, Bhatta Anil Kumar
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2017)
Article
Dermatology
Anil Kumar Bhatta, Uma Keyal, Xin Huang, Jing Jun Zhao
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2016)
Review
Engineering, Biomedical
Anil Kumar Bhatta, Uma Keyal, Xiuli Wang, Emese Gellen
LASERS IN MEDICAL SCIENCE
(2017)
Review
Oncology
Uma Keyal, Anil Kumar Bhatta, Xiu Li Wang
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2016)
Article
Dermatology
Meng Li, Lei Shi, Min Luo, Jia Chen, Bo Wang, Fuhe Zhang, Uma Keyal, Anil Kumar Bhatta, Wei R. Chen, Xiuli Wang
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2017)
Letter
Dermatology
Y. Gu, A. K. Bhatta, X. Du, M. Shao, U. Keyal, G. Zhang, Y. Hua
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2017)
Article
Oncology
Qian Zhou, Peiru Wang, Linglin Zhang, Bo Wang, Lei Shi, Uma Keyal, Anil Kumar Bhatta, Guolong Zhang, Xiuli Wang
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2017)
Letter
Dermatology
Uma Keyal, Anil Kumar Bhatta, Yeqiang Liu
DERMATOLOGICA SINICA
(2018)
Article
Biochemical Research Methods
Uma Keyal, Qiong Luo, Anil K. Bhatta, Hansen Luan, Ping Zhang, Qianqian Wu, Haiyan Zhang, Pei Liu, Linglin Zhang, Peiru Wang, Degang Yang, Guolong Zhang, Jing Yao, Xiuli Wang, Lei Shi
JOURNAL OF BIOPHOTONICS
(2018)
Article
Oncology
Uma Keyal, Anil Kumar Bhatta, Yeqiang Liu
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)
Article
Oncology
Uma Keyal, Anil Kumar Bhatta, Xiu Li Wang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)
Review
Medicine, Research & Experimental
Uma Keyal, Yeqiang Liu, Anil Kumar Bhatta
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
Review
Medicine, Research & Experimental
Uma Keyal, Yeqiang Liu, Anil Kumar Bhatta
DISCOVERY MEDICINE
(2018)
Letter
Dermatology
Anil Kumar Bhatta, Yeqiang Liu, Uma Keyal
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2018)