Article
Environmental Sciences
Catalina Lopez-Florez, Monica Andrea Ortiz Ruiz, Edwin Gomez-Ramirez
Summary: This study determined the effects of glyphosate on the skin of D. molitor tadpoles. The results showed that sublethal concentrations of glyphosate caused histopathological, ultrastructural, and morphometric alterations, which may affect the survival of the species in the natural environment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Olha M. Strilbytska, Uliana Semaniuk, Tetiana R. Strutynska, Nadia Burdyliuk, Sviatoslav Tsiumpala, Volodymyr Bubalo, Oleh Lushchak
Summary: Glyphosate-based herbicide Roundup has adverse effects on both larvae and adults of Drosophila melanogaster, causing developmental delay, increased mortality, altered glucose and glycogen levels, and changes in antioxidant defense system. Chronic exposure to adult flies also results in decreased appetite, body weight, and shortened lifespan.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Environmental Sciences
Xingping Chang, Furong Fu, Yang Sun, Lixia Zhao, Xiaojing Li, Yongtao Li
Summary: The excessive use of herbicides on farmlands can have negative effects on terrestrial ecosystems. In this study, the ecological toxicity of two commonly used herbicides, metolachlor and fomesafen, was evaluated using the earthworm Pheretima guillelmi. The herbicides depleted the energy resources of the earthworms, increased antioxidant enzyme levels, and inhibited acetylcholinesterase. The richness and diversity of the earthworms' intestinal bacterial community were also suppressed. Furthermore, the effects of metolachlor were temporary, while fomesafen had a stronger and long-lasting impact on the earthworms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biodiversity Conservation
Edward A. Straw, Edward N. Carpentier, Mark J. F. Brown
Summary: The study found that directly spraying the popular herbicide brand Roundup on bumble bees caused significant mortality, indicating that herbicides may pose a serious hazard to bees.
JOURNAL OF APPLIED ECOLOGY
(2021)
Article
Environmental Sciences
Homa Darmani, Dua'a Riyad Husain Al-Saleh
Summary: The study investigated the effects of different concentrations of glyphosate in Roundup on the hatchability, toxicity, and teratogenic effects of the aquatic crustacean Artemia salina. It was found that concentrations of 144 and 288 μg/ml glyphosate in Roundup inhibited cyst hatchability and were lethal to A. salina nauplii. Additionally, environmentally relevant concentrations of glyphosate (0.72 μg/ml) in Roundup affected the early development of A. salina nauplii and caused decreased body lengths and reduced widths. The study suggests the potential teratogenicity of Roundup even at environmentally safe concentrations of glyphosate.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Plant Sciences
Rodrigo Castaneda, Armando Caceres, Sully M. Cruz, J. Agustin Aceituno, E. Sebastian Marroquin, Ana C. Barrios Sosa, Wendy K. Strangman, R. Thomas Williamson
Summary: The prevalence of kidney disease has increased rapidly worldwide, and traditional plants used in Mesoamerican medicine by Mayan groups may provide valuable nephroprotective agents. This study found 208 plant species used for kidney-related problems by 10 Mayan groups, with 42 plants having reported pharmacological activity against kidney damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Environmental Sciences
Xuemei Meng, Jiawei Zhang, Wenjing Wang, Graciela Gonzalez-Gil, Johannes S. Vrouwenvelder, Zhenyu Li
Summary: The study revealed that nanoplastics and microplastics had toxic effects on the kidneys of mice, causing aggregation and biotoxicity, leading to weight loss, increased death rate, altered biomarkers, and kidney tissue damage. Additionally, exposure to these particles induced oxidative stress and inflammation in the mice.
Article
Medicine, Research & Experimental
Tomohiro Shigematsu, Soichiro Tajima, Rao Fu, Mengyu Zhang, Yuuka Itoyama, Akihiro Tsuchimoto, Nobuaki Egashira, Ichiro Ieiri
Summary: Research shows that everolimus attenuates tacrolimus-induced renal interstitial fibrosis through the inhibition of mTOR signaling. This finding provides guidance for the concomitant use of everolimus and tacrolimus in clinical practice.
Article
Reproductive Biology
Mercedes Torres-Badia, Soraya Solar-Malaga, David Martin-Hidalgo, Ana Hurtado de Llera, Andrea Gomez-Candelo, Luis J. Garcia-Marin, Lauro Gonzalez-Fernandez, Maria J. Bragado
Summary: The study reveals that low concentrations of Roundup herbicide cause impaired sperm motility in pigs without affecting sperm viability. This adverse effect is likely due to a detrimental effect in the plasma membrane lipid organization and inhibition of phosphorylation of GSK3 beta and specific PKA substrates.
Article
Green & Sustainable Science & Technology
Catia Venancio, Cristina Barbosa, Isabel Lopes
Summary: This study evaluated and compared the effects of glyphosate and its commercial formulation Roundup on the Hydra viridissima life cycle. It was found that the commercial formulation caused more severe morphological alterations and hindered complete regeneration, while the pure glyphosate showed a high recovery capacity. The commercial formulation also had negative impacts on feeding and reproduction of the hydra. These results suggest that adjuvants in the commercial formulation may increase the toxicity of glyphosate to biota.
Article
Ecology
Gabriela Alves-Ferreira, Marco Katzenberger, Fernanda Guimaraes Fava, Renan Nunes Costa, Leildo Machado Carilo Filho, Mirco Sole
Summary: Studies have shown that pollution and temperature changes have negative effects on the survival and development of amphibian larvae, especially the effects of herbicides on morphology, size, and thermal tolerance. Further investigation reveals an additive effect of herbicides and temperature increase on larval survival. These findings provide a promising direction for future research.
Article
Biochemistry & Molecular Biology
Sonalika Singhal, Scott H. Garrett, Seema Somji, Kalli Schaefer, Benu Bansal, Jappreet Singh Gill, Sandeep K. Singhal, Donald A. Sens
Summary: The human kidney contains renal progenitor cells (RPCs) that can help repair acute tubular injury. A human renal progenitor cell line (HRTPT) was generated that displayed the expected features of RPCs, such as nephrosphere formation and differentiation into various cell types. When exposed to nephrotoxin iAs, the cells underwent a shift in morphology and showed changes in gene expression related to epithelial-mesenchymal transition (EMT). However, when the toxin was removed, the cells reverted back to an epithelial phenotype through a process called mesenchymal-epithelial transition (MET).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Khaoula Telahigue, Imen Rabeh, Tarek Hajji, Wafa Trabelsi, Chaima Fouzai, Salwa Nechi, Emna Chelbi, M'hamed El Cafsi, Nejla Soudani
Summary: This study evaluated the potential hazardous impacts of glyphosate acid and its commercial formulation on sea cucumbers for the first time, revealing that both forms promoted oxidative stress, perturbed fatty acid composition, and modulated antioxidant defense status. The commercial formulation had a more pronounced effect on sea cucumbers than the pure form.
Article
Biochemistry & Molecular Biology
Hyoung-Yun Han, Mi-Sun Choi, Seokjoo Yoon, Je-Won Ko, Sang-Kyum Kim, Tae-Won Kim
Summary: This study confirmed kidney-biased organ toxicity of ifosfamide in rats, with identically altered genes in both the liver and kidney. Interferon regulatory factor 7 was identified as the main upstream regulator that changed in both organs. Further toxicogenomic studies are needed to fully understand the relationship between ifosfamide-induced genes and organ toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Esra Nur Yesilkent, Hamid Ceylan
Summary: This study found that tannic acid (TA) can prevent doxorubicin (DOX)-induced kidney damage and improve the dysregulation of antioxidant metabolism caused by DOX. Combination treatment with TA and DOX can restore the abnormal gene expressions induced by DOX, suggesting that TA provides kidney protection by remodeling stress resistance, cell metabolism, inflammation, and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Environmental Sciences
Folarin Owagboriaye, Gabriel Dedeke, Kehinde Ademolu, Olanrewaju Olujimi, Adeyinka Aladesida, Mistura Adeleke
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2019)
Article
Entomology
Julius Akolawole Bamidele, Adewumi Babatunde Idowu, Kehinde Ademolu, Adebola Adedoyin Osipitan
Summary: This study evaluated the nutritional and anti-nutritional composition of honey bees from different ecological zones in Nigeria. The results showed no significant differences in the nutritional components among the honey bees from the three ecological zones, but the level of phytate exceeded the regulatory safe level.
JOURNAL OF APICULTURAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Folarin Owagboriaye, Sulaimon Aina, Rasheed Oladunjoye, Titilola Salisu, Adedamola Adenekan, Adeyinka Aladesida, Gabriel Dedeke
Summary: This study investigated the nephrotoxicity of gasoline fumes by examining the residue of gasoline components in the kidney of rats. The results demonstrated that exposure to gasoline fumes caused biochemical, histological, and metabolic changes in the kidney.
Article
Chemistry, Multidisciplinary
Folarin Owagboriaye, Oladunni Adekunle, Rasheed Oladunjoye, Mistura Adeleke, Sulaimon Aina, Adedamola Adenekan, Pamilerin Bakare, Oyebamiji Fafioye, Gabriel Dedeke, Olusegun Lawal
Summary: There is a high reliance on atrazine herbicide for weed control in rural maize farms in Nigeria. A survey was conducted to assess atrazine residue in water sources from six communities in Southwest Nigeria. The highest concentration of atrazine detected in the water was found to increase corticosterone and aldosterone levels in rats. However, environmentally relevant concentrations of atrazine did not significantly affect the hypothalamic-pituitary-adrenal (HPA) axis.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Folarin Owagboriaye, Rasheed Oladunjoye, Oladunni Adekunle, Titilola Salisu, Adedamola Adenekan, Promise Ojadeni, Gabriel Dedeke, Olusegun Lawal
Summary: This study conducted in rural agricultural areas of Nigeria for the first time monitored the presence of atrazine in drinking water and its potential health implications. It was found that some of the tested wells and streams contained atrazine, but the current concentrations of atrazine in the water sources pose acceptable non-carcinogenic risks for both adults and children.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Toxicology
Folarin Owagboriaye, Robin Mesnage, Gabriel Dedeke, Taofeek Adegboyega, Adeyinka Aladesida, Mistura Adeleke, Stephen Owa, Michael N. Antoniou
Summary: This study investigated the impact of a glyphosate-based herbicide on the gut microbial communities of three earthworm species and found a profound shift in bacterial populations in all exposed earthworms with Proteobacteria becoming the dominant phylum. Affected bacteria were mostly from the genus Enterobacter, Pantoea and Pseudomonas, which together represented approximately 80% of the total abundance assigned at the genus level in exposed earthworms.
TOXICOLOGY REPORTS
(2021)
Article
Entomology
Julius Akolawole Bamidele, Adewumi Babatunde Idowu, Kehinde Olutoyin Ademolu, Adebola Adedoyin Osipitan
Summary: The study evaluated the body allometry of honey bees from different ecological zones in Nigeria, finding that honey bees from the rainforest zone had significantly higher body weight, total body length, and mouth width. The lengths of thorax and abdomen of honey bees from the rainforest and Guinea savannah zones showed a significant linear relationship with total body length. Length-weight relationship revealed a positive allometric growth pattern in honey bees from the rainforest zone, and a negative allometric pattern in bees from the other zones.
BULLETIN OF INSECTOLOGY
(2021)
Article
Entomology
Olubusola Temitope Adeoye, Olufemi Richard Pitan, Kehinde Olutoyin Ademolu, Ayangbade Emmanuel Ayandokun
Summary: The study analyzed morphological variations in honeybees from different regions in Nigeria, finding significant differences within and among populations in different agro-ecological zones. The results suggest the existence of ecotypes in Nigerian honeybees, which could impact future bee breeding programs for Apis mellifera in Sudan and rainforest zones of Nigeria. Efforts to enhance honeybee conservation should be encouraged to preserve existing populations.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2021)
Article
Entomology
A. B. Idowu, E. O. Oliyide, K. O. Ademolu, J. A. Bamidele
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2019)
Article
Multidisciplinary Sciences
F. O. Owagboriaye, G. A. Dedeke, A. A. Aladesida, J. A. Bamidele, W. E. Olooto
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2018)
Review
Environmental Sciences
Ebenezer Olasunkanmi Dada, Modupe Olatunde Akinola, Stephen Olugbemiga Owa, Gabriel Adewunmi Dedeke, Adeyinka A. Aladesida, Folarin O. Owagboriaye, Emmanuel O. Oludipe
Summary: This study reviews the effectiveness of using earthworms to remediate organic and inorganic soil contaminants, describing their actions in this process, clarifying the usage of terms in environmental health studies, and highlighting the challenges and limitations of vermiremediation.
JOURNAL OF HEALTH AND POLLUTION
(2021)