Review
Chemistry, Multidisciplinary
Zhichao Liu, Ying Zhu, Liming Zhang, Weiping Jiang, Yawei Liu, Qiaowei Tang, Xiaoqing Cai, Jiang Li, Lihua Wang, Changlu Tao, Xianzhen Yin, Xiaowei Li, Shangguo Hou, Dawei Jiang, Kai Liu, Xin Zhou, Hongjie Zhang, Maili Liu, Chunhai Fan, Yang Tian
Summary: Analyzing the complex structures and functions of the brain is crucial for understanding physiological and pathological processes. However, subcellular structures of cells in the live brain and the concentrations, distributions, and interactions of functional molecules are still poorly understood.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Physiology
Ferdinando Iellamo, Marco Alfonso Perrone, Giuseppe Caminiti, Maurizio Volterrani, Jacopo M. Legramante
Summary: The study found that in coronary artery patients, the recovery phase after exercise is characterized by post-exercise hypotension (PEH), which is mainly mediated by generalized peripheral vasodilation and appears to influence blood pressure behavior throughout daily life. Additionally, the cardiac component of the arterial baroreflex seems to indirectly contribute to the blood pressure reduction occurring after exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Peter Novak, Shibani S. Mukerji, Haitham S. Alabsi, David Systrom, Sadie P. Marciano, Donna Felsenstein, William J. Mullally, David M. Pilgrim
Summary: This study aimed to describe the cerebrovascular, neuropathic, and autonomic features of post-acute sequelae of COVID-19 (PASC). The study found that PASC is associated with multisystem abnormalities, including cerebrovascular dysregulation, small fiber neuropathy, and autonomic dysfunction, along with chronic inflammation.
ANNALS OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Xue Jiao, Ming Yuan, Qiuju Li, Yufei Huang, Miaomiao Ji, Jing Li, Shumin Yan, Hao Sun, Xinyu Wang, Zangyu Pan, Qianhui Ren, Dawei Wang, Guoyun Wang
Summary: This study used resting-state functional magnetic resonance imaging to investigate brain morphological alterations and regional dysfunctions in patients with adenomyosis-related pain. The results showed changes in multiple brain regions associated with pain as well as anxiety and depression symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Michael Hutel, Michela Antonelli, Andrew Melbourne, Sebastien Ourselin
Summary: The General Linear Model used in task-fMRI has limitations in assuming neural activation is binary and in treating task-unrelated brain activity as noise. The Hemodynamic Matrix Factorization (HMF) method addresses these limitations by modeling both types of brain activity with the same convolution model.
Article
Physiology
Alessandro Fornasiero, Andrea Zignoli, Mark Rakobowchuk, Federico Stella, Aldo Savoldelli, Spyros Skafidas, Federico Schena, Barbara Pellegrini, Laurent Mourot
Summary: This study found that moderate HR-matched hypoxic exercise mimicked post-exercise autonomic responses of normoxic exercise without significant post-exercise hypotension. However, WR-matched hypoxic exercise impacted post-exercise autonomic and cardiovascular responses, delaying cardiac autonomic recovery, temporarily decreasing cBRS, and evoking prolonged PEH.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Leandro O. Carpes, Lucas B. Domingues, Otavio Bertoletti, Sandra C. Fuchs, Rodrigo Ferrari
Summary: There is a high inter-individual variation in blood pressure after different exercise modalities in older adults with hypertension, and various exercise modalities might acutely reduce 24-hour blood pressure in this population.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Suresh L. Mehta, Anil K. Chokkalla, Saivenkateshkomal Bathula, Raghu Vemuganti
Summary: miR-7 plays a crucial role in preventing alpha-Syn induction and brain damage after stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Sport Sciences
Eduardo Marcel Fernandes Nascimento, Paulo Cesar do Nascimento Salvador, Diego Antunes, Leonardo Trevisol Possamai, Thiago Ventura, Luiz Guilherme Antonacci Guglielmo, Benedito Sergio Denadai, Ricardo Dantas de Lucas
Summary: This study aimed to investigate the HRV and HR kinetics during cycling exercise in different intensity domains. The results showed significant differences in HR between Delta 30 and Delta 60, with HRV markers accelerating at higher intensities. The findings suggest distinct cardiac autonomic response times for HR and HRV markers in various intensity domains.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Review
Neurosciences
Hongzan Sun, Yong He, Heqi Cao
Summary: NSFC has been funding various research programs related to fMRI over the past two decades, with increasing support particularly in the General Program and Key Program. Leading research institutes in economically developed provinces and municipalities received the most support and established close collaboration relationships. Notable achievements in data analysis methods, brain connectomes, and computational platforms as well as their applications in brain disorders were reviewed.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Moattar Raza Rizvi, Ankita Sharma, Ahmed Malki, Waqas Sami
Summary: This study compared stroke-specific rehabilitation with individualized cardiac rehabilitation exercises in stroke patients. The results showed that individualized cardiac rehabilitation exercises had significant improvements in balance, mobility, cardiovascular fitness, respiratory performance, exercise efficiency, and autonomic function in stroke patients, while stroke-specific rehabilitation did not show significant improvements in these parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Giuseppe Caminiti, Ferdinando Iellamo, Marco Alfonso Perrone, Valentino D'Antoni, Matteo Catena, Vincenzo Manzi, Valentina Morsella, Alessio Franchini, Maurizio Volterrani
Summary: The study showed that both RAE and HIIE are effective in inducing post-exercise hypotension in hypertensive patients, but the central hemodynamic changes in hypertensive patients with underlying ischemic heart disease have not been well studied. RAE seems more suitable for reducing blood pressure in hypertensive patients with ischemic heart disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
He Huang, Chuanyin Cheng
Summary: This study conducted a systematic review of brain function activation changes associated with video games and found potential benefits of video games on cognitive function, particularly on attention and visuospatial ability. When discussing the effect of video games on brain function, careful categorization based on game types is necessary.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Szu-Yu Lin, Chi-Wen Jao, Po-Shan Wang, Michelle Liou, Jun-Liang Wu, Hsiao Chun, Ching-Ting Tseng, Yu-Te Wu
Summary: This study compared changes in brain activity during exercise between elderly and young adults with regular and occasional exercise habits. The results showed a significant positive correlation between exercise intensity and EEG spectral power in elderly regular exercisers, but not in occasional exercisers. Young regular exercisers exhibited greater cardiac and neurobiological efficiency.
Article
Endocrinology & Metabolism
Anna Vagvolgyi, Judit Erzsebet Abraham, Eva Mathene Koteles, Andrea Korom, Maria Barnai, Monika Szucs, Andrea Orosz, Peter Kempler, Adrienn Menyhart, Attila Nemes, Tamas Varkonyi, Istvan Baczko, Istvan Kosa, Csaba Lengyel
Summary: The aim of this study was to measure the cardiovascular autonomic function following physical training in patients with metabolic syndrome with and without diabetes. The results showed that a three-month exercise program improved Valsalva-ratio and autonomic score in MetS patients and had positive effects on blood pressure and stress-ECG results in both groups. However, there were no significant changes in reflex test results in the DMetS group, indicating impaired adaptation compared to the NDMetS group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuro Tago, Jun Toyohara, Ryuichi Harada, Shozo Furumoto, Nubuyuki Okamura, Yukitsuka Kudo, Junko Takahashi-Fujigasaki, Shigeo Murayama, Kenji Ishii
ANNALS OF NUCLEAR MEDICINE
(2019)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Tetsuro Tago, Jun Toyohara, Renpei Sengoku, Shigeo Murayama, Kenji Ishii
CLINICAL NUCLEAR MEDICINE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Toyohara, Hiroyuki Yamamoto, Tetsuro Tago
ANNALS OF NUCLEAR MEDICINE
(2019)
Review
Biochemistry & Molecular Biology
Hiroyuki Yamamoto, Kenji Wada, Jun Toyohara, Tetsuro Tago, Masanobu Ibaraki, Toshibumi Kinoshita, Yuka Yamamoto, Yoshihiro Nishiyama, Nobuyuki Kudomi
CARBOHYDRATE RESEARCH
(2019)
Article
Biochemical Research Methods
Tetsuro Tago, Jun Toyohara, Kenji Ishii
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Toyohara, Muneyuki Sakata, Tetsuro Tago, Nicola A. Colabufo, Gert Luurtsema
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Toyohara, Norihiro Harada, Takeharu Kakiuchi, Hiroyuki Ohba, Masakatsu Kanazawa, Tetsuro Tago, Muneyuki Sakata, Kiichi Ishiwata
Article
Medicine, Research & Experimental
Lara Garcia-Varela, David Vallez Garcia, Takeharu Kakiuchi, Hiroyuki Ohba, Shingo Nishiyama, Tetsuro Tago, Philip H. Elsinga, Hideo Tsukada, Nicola A. Colabufo, Rudi A. J. O. Dierckx, Aren van Waarde, Jun Toyohara, Ronald Boellaard, Gert Luurtsema
Summary: This study aimed to evaluate the pharmacokinetics of (R)-[C-11]verapamil in nonhuman primates and establish it as a reference tracer for P-gp in comparison with other PET tracers. The results suggest that using the 1-tissue compartment model and shorter PET scan durations can be suitable for measuring P-gp function at the blood-brain barrier in nonhuman primates.
MOLECULAR PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Tetsuro Tago, Jun Toyohara, Kenji Ishii
Summary: The study focused on the synthesis and evaluation of an F-18-labeled compound [F-18]2 as a radioligand for brain HDAC6 imaging, showing good penetration and moderate stability in the mouse brain. Blocking studies demonstrated selective binding of [F-18]2 by HDAC6 inhibitors, suggesting its potential usefulness as a PET radioligand for brain HDAC6 imaging.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Jun Toyohara, Kosuke Nishino, Masanari Sakai, Tetsuro Tago, Takashi Oda
Summary: Automated production of [F-18]MK-6240 was successfully implemented for the first time in the CFN-MPS200 module, with three consecutive productions meeting product specifications. The formulated [F-18]MK-6240 maintained stability over 8 hours, as measured by radio-high-performance liquid chromatography (HPLC), clarity, and pH. This established method has the potential to facilitate multi-center trials and widespread use of [F-18]MK-6240.
APPLIED RADIATION AND ISOTOPES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Toyohara, Muneyuki Sakata, Kenji Ishibashi, Pascalle Mossel, Masamichi Imai, Kei Wagatsuma, Tetsuro Tago, Etsuko Imabayashi, Nicola A. Colabufo, Gert Luurtsema, Kenji Ishii
Summary: [F-18]MC225 is a suitable and safe PET tracer for measuring P-gp function at the blood-brain barrier. Utilizing PET scanning techniques, its dosage and distribution can be effectively measured, with homogeneous distribution in the brain.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jun Toyohara, Muneyuki Sakata, Kei Wagatsuma, Tetsuro Tago, Kenji Ishibashi, Kenji Ishii, Philip Elsinga, Kiichi Ishiwata
Summary: The study evaluated the reproducibility of cerebral adenosine A(2A) receptor quantification using [C-11]preladenant and PET in a test-retest study. Results showed moderate test-retest reproducibility and significant inter-subject differences, possibly due to competition by baseline amount of caffeine. Analysis of plasma caffeine concentration is recommended during [C-11]preladenant PET studies.
ANNALS OF NUCLEAR MEDICINE
(2022)