Review
Oncology
Eric K. Nguyen, Mark Ruschin, Beibei Zhang, Hany Soliman, Sten Myrehaug, Jay Detsky, Hanbo Chen, Arjun Sahgal, Chia-Lin Tseng
Summary: Stereotactic body radiotherapy (SBRT) is highly effective for selected patients with spinal metastases. Compared to conventional external beam radiotherapy (cEBRT), SBRT shows improvements in pain response rates and local control with lower retreatment rates. The dose-fractionation of 24 Gy in 2 fractions provides an excellent balance between treatment toxicity and patient convenience.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Daniel Moore-Palhares, Arjun Sahgal, K. Liang Zeng, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Mark Ruschin, Eshetu G. Atenafu, Jeff Wilson, Jeremie Larouche, Leodante da Costa, Pejman Jabehdar Maralani, Hany Soliman
Summary: This study reports the outcomes of a novel fractionation scheme, 30 Gy in 4 fractions, for the treatment of spinal metastases. The results show that this approach is safe and effective, especially for patients with a clinical target volume (CTV) volume of ≥72 cc.
Article
Oncology
K. Liang Zeng, Ahmed Abugarib, Hany Soliman, Sten Myrehaug, Zain A. Husain, Jay Detsky, Mark Ruschin, Aliaksandr Karotki, Eshetu G. Atenafu, Jeremie Larouche, Mikki Campbell, Pejman Maralani, Arjun Sahgal, Chia-Lin Tseng
Summary: Stereotactic body radiation therapy (SBRT) for spine metastases improves pain response rates compared with conventional external beam radiation therapy. This study investigates the optimal fractionation schedule and reports improved local control with dose-escalated 2-fraction spine SBRT. The results show that a dose of 28 Gy in 2 fractions is associated with better local control without increasing the risk of vertebral compression fracture (VCF).
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Raquel Ciervide, Ovidio Hernando, Mercedes Lopez, Angel Montero, Daniel Zucca, Emilio Sanchez, Beatriz Alvarez, Mariola Garcia-Aranda, Xin Chen Zhao, Jeannette Valero, Rosa Alonso, Jaime Marti, Miguel Angel de la Casa, Leire Alonso, Juan Garcia, Paz Garcia de Acilu, Alejandro Prado, Pedro Fernandez Leton, Carmen Rubio
Summary: This study evaluated the clinical outcomes of patients with spine metastases treated with SBRT. The results showed that SBRT was effective in providing pain relief and achieving local control. The overall survival rate was also relatively high.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Matthias Guckenberger, Frederick Mantel, Reinhart A. Sweeney, Maria Hawkins, Jose Belderbos, Merina Ahmed, Nicolaus Andratschke, Indira Madani, Michael Flentje
Summary: The study demonstrates that fractionated SBRT is effective in providing long-term pain relief and improved survival rates for patients with painful spinal metastases. Partial pain response was achieved in some patients at 3 months' follow-up and remained stable up to 5 years. Furthermore, fractionated SBRT resulted in long-term improvements in multiple dimensions of the EuroQol 5-Dimension Questionnaire.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Siyuan Qin, Weili Zhao, Qizheng Wang, Ke Liu, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to develop response prediction models for patients with spinal metastases undergoing stereotactic body radiotherapy (SBRT) by extracting radiomics features from MRI using machine learning algorithms. The results showed that the MRI-based radiomics models have valuable predictive capability for treatment outcomes in these patients.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Sten Myrehaug, John Hudson, Hany Soliman, Mark Ruschin, Chia-Lin Tseng, Jay Detsky, Zain Husain, Julia Keith, Eshetu G. Atenafu, Pejman Maralani, Chris Heyn, Sunit Das, Nir Lipsman, Arjun Sahgal
Summary: This study aimed to report mature image-based outcomes for MLC-Linac HSRT, focusing on clinical and dosimetric factors associated with local failure (LF). The results showed that daily 5-fraction 30Gy HSRT treatment can achieve optimal local control, irrespective of tumor volume and histology, with an acceptable risk of radiation necrosis.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Niccolo Giaj-Levra, Vanessa Figlia, Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attina, Claudio Vitale, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri, Filippo Alongi
Summary: This study evaluated an automatic contouring tool for spine SBRT, demonstrating its ability to reduce inter-observer differences in target definition and increase precision in SBRT treatment of the spine.
RADIATION ONCOLOGY
(2021)
Article
Oncology
K. Liang Zeng, Arjun Sahgal, Zain A. Husain, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Arman Sarfehnia, Mark Ruschin, Mikki Campbell, Monica Foster, Sunit Das, Nir Lipsman, Georg A. Bjarnason, Eshetu G. Atenafu, Pejman Jabehdar Maralani, Hany Soliman
Summary: The study found higher rates of LF after spine SBRT in RR metastases. Optimization strategies include dose escalation and aggressive management of epidural disease.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Raj Singh, Anisha Valluri, Jan Jenkins, Joanne Davis, John A. Vargo, Sanjeev Sharma
Summary: This study compared clinical outcomes of single fraction versus fractionated stereotactic body radiotherapy for spinal metastases. Overall survival rates were influenced by performance status, age, and primary site. Initial complete response rates in pain response were associated with BED10 >= 51 Gy(10).
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2022)
Article
Oncology
Yilin Cao, Hanbo Chen, Arjun Sahgal, Darby Erler, Serena Badellino, Tithi Biswas, Roi Dagan, Matthew C. Foote, Alexander Louie, Ian Poon, Umberto Ricardi, Kristin J. Redmond
Summary: This study reviewed oligometastatic patients treated with SBRT for spine and non-spine bone lesions at six international institutions, finding no significant difference in local recurrence, widespread progression, and overall survival between the two groups. Dose escalation for large and/or radioresistant non-spine bone lesions should be considered.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Biology
Robert Rockenfeller
Summary: This study aims to investigate the changes in spinal shape during daily activities and identify which parts undergo significant changes. Motion capture data from 17 healthy individuals were used to analyze spinal shape characteristics. The results show that individual spinal shape is recognizably preserved during all activities, with walking having no significant effect on spinal curvature, while sitting and forward bending significantly altering the lumbar and whole spine curvature, respectively. Torsion did not show any significant alterations.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Oncology
E. M. Dunne, M. C. Liu, S. S. Lo, A. Sahgal
Summary: With advancements in targeted and immunotherapies, the number of spinal metastases cases is increasing, and there is a growing need for local management strategies beyond conventional radiation therapy. Stereotactic body radiation therapy (SBRT) is a highly conformal technique that allows precise targeting of vertebral lesions while minimizing damage to adjacent neural tissue. However, identifying the most suitable patients for SBRT in the palliative setting remains a challenge.
Article
Clinical Neurology
Pejman Jabehdar Maralani, Chia-Lin Tseng, Hamidreza Baharjoo, Erin Wong, Anish Kapadia, Archya Dasgupta, Peter Howard, Aimee K. M. Chan, Eshetu G. Atenafu, Hua Lu, Pascal Tyrrell, Sunit Das, Seyedmehdi Payabvash, Jay Detsky, Zain Husain, Sten Myrehaug, Hany Soliman, Hanbo Chen, Chris Heyn, Sean Symons, Arjun Sahgal
Summary: This study aimed to determine the minimum detectable difference in GTV based on MRI and found that larger volume changes were required before local failure could be determined for small tumors compared to medium/large tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberto Luigi Cazzato, Jack W. Jennings, Pierre-Alexis Autrusseau, Pierre De Marini, Pierre Auloge, Anderanik Tomasian, Julien Garnon, Afshin Gangi
Summary: This study reports on the safety and clinical effectiveness of cryoablation for the treatment of spinal metastases (SM) in patients needing pain palliation or local tumor control (LTC). The study found that cryoablation combined with vertebral augmentation is a safe and effective treatment option for SM, providing fast and sustained pain relief and high rates of LTC at a 2-year follow-up.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
K. Liang Zeng, Ahmed Abugarib, Hany Soliman, Sten Myrehaug, Zain A. Husain, Jay Detsky, Mark Ruschin, Aliaksandr Karotki, Eshetu G. Atenafu, Jeremie Larouche, Mikki Campbell, Pejman Maralani, Arjun Sahgal, Chia-Lin Tseng
Summary: Stereotactic body radiation therapy (SBRT) for spine metastases improves pain response rates compared with conventional external beam radiation therapy. This study investigates the optimal fractionation schedule and reports improved local control with dose-escalated 2-fraction spine SBRT. The results show that a dose of 28 Gy in 2 fractions is associated with better local control without increasing the risk of vertebral compression fracture (VCF).
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Review
Oncology
Grace Kusi, Eshetu G. Atenafu, Adwoa Bemah Boamah Mensah, Charlotte T. Lee, Auro Viswabandya, Martine Puts, Samantha Mayo
Summary: Psychoeducational intervention (PEI) has a positive effect on cancer caregivers, reducing caregiver burden, improving quality of life, and reducing anxiety and depression. The study also found that intervention characteristics such as studies conducted in high-income countries, group interventions, and studies focused on specific and mixed cancers can impact the effectiveness of the intervention.
Letter
Hematology
Marta Davidson, Florence Wong, Mostafa Atri, Hassan Sibai, Dawn Maze, Verna Cheung, Jeannie Callum, Eshetu G. Atenafu, Vikas Gupta
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Maria Queralt Salas, Eshetu G. G. Atenafu, Ivan Pasic, Eshrak Al-Shaibani, Ora Bascom, Leeann Wilson, Carol Chen, Arjun Datt Law, Wilson Lam, Igor Novitzky-Basso, Dennis (Dong Hwan) Kim, Armin Gerbitz, Auro Viswabandya, Fotios V. V. Michelis, Jeffrey Howard Lipton, Jonas Mattsson, Shabbir Alibhai, Rajat Kumar
Summary: This study designs an HCT Frailty Scale to classify alloHCT candidates into different frailty groups, which can be implemented in the first consultation without additional cost. The scale uses eight variables to assess and calculate the frailty score of a patient, which can predict the one-year overall survival rate. The scale is a low-cost and highly informative prognostic signal for outcomes at the pre-transplant stage.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Sahar Khan, Donna Reece, Eshetu G. Atenafu, Sita Bhella, Christine Chen, Esther Masih-Khan, Harminder Paul, Anca Prica, Rodger Tiedemann, Suzanne Trudel, Vishal Kukreti
Summary: A retrospective evaluation was conducted on 106 multiple myeloma patients who underwent upfront therapy with PI based induction and ASCT (+/- IMiD maintenance) to assess the outcome of salvage ASCT. At a median follow-up of 26 months, the estimated median PFS and OS were 24 and 80 months respectively. PFS post ASCT1 of at least 42 months and IMiD non-refractory disease were associated with improved outcome.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Article
Clinical Neurology
Anish Kapadia, Krish Billimoria, Prarthna Desai, James T. Grist, Chris Heyn, Pejman Maralani, Sean Symons, Fulvio Zaccagna
Summary: This study found significant differences in cerebral blood flow (CBF) in the left entorhinal cortex between patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI), and cognitively normal (CN) individuals. The difference in CBF was inversely associated with tau deposition in the left entorhinal cortex after 6 years. CBF can predict tau deposition after 6 years.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Hematology
RuiQi Chen, Eshetu G. Atenafu, Jack Seki, Xing Liu, Steven Chan, Vikas Gupta, Dawn Maze, Andre C. Shuh, Mark D. Minden, Karen Yee, Aaron D. Schimmer, Hassan Sibai
Summary: This study found that PEG-ASP is associated with a higher incidence of VTE compared to L-ASP in patients with ALL, despite prophylactic anticoagulation. Further VTE mitigation strategies are needed for adult patients receiving PEG-ASP.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Jawad M. Melhem, Ali Tahir, Eirena Calabrese, Inga Granovskaya, Eshetu G. Atenafu, Arjun Sahgal, Mary Jane Lim-Fat, James R. Perry
Summary: This study aimed to validate the safety and efficacy of low-dose bevacizumab (BEV) for patients with recurrent glioblastoma (rGBM). The study found that compared to the standard dose regimen, low-dose BEV was associated with significantly prolonged overall survival and progression-free survival. Lower dose schedules may be a better and more cost-effective option, providing more equitable access to the palliative drug.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Daniel Moore-Palhares, Arjun Sahgal, K. Liang Zeng, Sten Myrehaug, Chia-Lin Tseng, Jay Detsky, Hanbo Chen, Mark Ruschin, Eshetu G. Atenafu, Jeff Wilson, Jeremie Larouche, Leodante da Costa, Pejman Jabehdar Maralani, Hany Soliman
Summary: This study reports the outcomes of a novel fractionation scheme, 30 Gy in 4 fractions, for the treatment of spinal metastases. The results show that this approach is safe and effective, especially for patients with a clinical target volume (CTV) volume of ≥72 cc.
Article
Oncology
James Stewart, Arjun Sahgal, Mahtab M. Zadeh, Bahareh Moazen, Pejman Jabehdar Maralani, Stephen Breen, Angus Lau, Shawn Binda, Brian Keller, Zain Husain, Sten Myrehaug, Jay Detsky, Hany Soliman, Chia-Lin Tseng, Mark Ruschin
Summary: Magnetic resonance image-guided radiotherapy for intracranial indications is a promising advance, but uncertainties remain for both target localization after translation-only MR setup and intrafraction motion. This investigation quantified these uncertainties and developed a population-based PTV model to explore target and OAR volumetric coverage tradeoffs.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Clinical Neurology
Chris Heyn, Alan R. Moody, Chia-Lin Tseng, Erin Wong, Tony Kang, Anish Kapadia, Peter Howard, Pejman Maralani, Sean Symons, Maged Goubran, Anne Martel, Hanbo Chen, Sten Myrehaug, Jay Detsky, Arjun Sahgal, Hany Soliman
Summary: This study demonstrates the accurate and reproducible segmentation of brain metastases using a semi-automated algorithm called BLAST. The results show that BLAST has potential as a tool for radiation planning and evaluating treatment response.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Oncology
Nazanin Aghel, Dakota Gustafson, Diego Delgado, Eshetu G. Atenafu, Jason E. Fish, Jeffrey H. Lipton
Summary: Tyrosine kinase inhibitors (TKIs) have had a significant impact on the treatment of chronic myelogenous leukemia (CML), but they may have cardiovascular toxicities. This study examined the relationship between the marker hsCRP and vascular dysfunction markers with exposure to specific TKIs in CML patients. The results showed that hsCRP levels were not associated with disease activity or treatment with specific TKIs, but other markers of vascular dysfunction were altered in patients treated with certain TKIs.
LEUKEMIA & LYMPHOMA
(2023)
Article
Oncology
Wee Loon Ong, Melanie Davidson, Patrick Cheung, Hans Chung, William Chu, Jay Detsky, Stanley Liu, Gerard Morton, Ewa Szumacher, Chia-Lin Tseng, Danny Vesprini, Ananth Ravi, Merrylee Mcguffin, Liying Zhang, Alexandre Mamedov, Andrea Deabreu, Meghan Kulasingham-Poon, Andrew Loblaw
Summary: This study aimed to correlate dosimetric parameters with toxicities and quality of life outcomes in two-fraction prostate stereotactic ablative radiotherapy (SABR). The results showed that dose parameters of the bladder and penile bulb were associated with toxicities, highlighting the importance of dose constraints in mitigating treatment-related side effects.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Pejman Jabehdar Maralani, Rachel W. Chan, Wilfred W. Lam, Wendy Oakden, Ryan Oglesby, Angus Lau, Hatef Mehrabian, Chris Heyn, Aimee K. M. Chan, Hany Soliman, Arjun Sahgal, Greg J. Stanisz
Summary: Chemical exchange saturation transfer (CEST) is a magnetic resonance imaging (MRI) technique used to measure certain endogenous molecules that exchange with water protons. Recent technological advances have enabled CEST to be implemented on clinical grade scanners, and most neuro-oncology applications of CEST do not require the use of contrast agents.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
