期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 42, 期 9, 页码 1639-1650出版社
SPRINGERNATURE
DOI: 10.1038/s41366-018-0152-8
关键词
-
资金
- TRYG Foundation [11683, 115606, 104982]
- Christian og Ottilia Brorsons Rejselegat
- MedImmune
- BHF fellowship [FS/12/58/29709]
- UK Medical Research Council [MC_UU_12015/3]
- Research Council of Norway [249932/F20]
- European Research Council [716657]
- National Prevention Research Initiative [G0701877]
- British Heart Foundation
- Cancer Research UK
- Department of Health
- Diabetes UK
- Economic and Social Research Council
- Medical Research Council
- Research and Development Office for the Northern Ireland Health and Social Services
- Chief Scientist Office
- Scottish Executive Health Department
- Stroke Association
- Welsh Assembly Government
- World Cancer Research Fund
- Medical Research Council [MC_UU_12015/3, MC_UU_12015/7]
- Bristol University
- Loughborough University
- Wellcome Trust [102215/2/13/2]
- UK Medical Research Council
- University of Bristol
- British Heart Foundation [PG106/145]
- Norwegian School of Sport Sciences
- MRC [G0701877, MC_UU_12015/7, MC_UU_12015/3, MC_U106179473, MR/K023187/1] Funding Source: UKRI
Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4-18 years). Accelerometry data was summarized as time accumulated in 16 combinations of intensity thresholds (>= 500 to >= 3000 counts/min) and bout-durations (>= 1 to >= 10 min). Outcomes were body mass index (BMI, kg/m(2)), waist circumference, biochemical markers, blood pressure, and a composite score of these metabolic markers. A second composite score excluded the adiposity component. Linear mixed models were applied to elucidate the associations and expressed per 10 min difference in daily activity above the intensity/bout-duration combination. Estimates (and variance) from each of the 16 combinations of intensity and bout-duration examined in the linear mixed models were analyzed in meta-regression to investigate trends in the association. Results: Each 10 min positive difference in physical activity was significantly and inversely associated with the risk factors irrespective of the combination of intensity and bout-duration. In meta-regression, each 1000 counts/min increase in intensity threshold was associated with a -0.027 (95% CI: -0.039 to -0.014) standard deviations lower composite risk score, and a -0.064 (95% CI: -0.09 to -0.038) kg/m(2) lower BMI. Conversely, meta-regression suggested bout-duration was not significantly associated with effect-sizes (per 1 min increase in bout-duration: -0.002 (95% CI: -0.005 to 0.0005) standard deviations for the composite risk score, and -0.005 (95% CI: -0.012 to 0.002) kg/m(2) for BMI). Conclusions: Time spent at higher intensity physical activity was the main determinant of variation in cardiometabolic risk factors, not bout-duration. Greater magnitude of associations was consistently observed with higher intensities. These results suggest that, in children and adolescents, physical activity, preferably at higher intensities, of any bout-duration should be promoted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据