Article
Pharmacology & Pharmacy
Marianne J. Naguib, Amal I. A. Makhlouf
Summary: Flibanserin nanocrystals were prepared using sono-precipitation technique and formulated into sublingual tablets for improved bioavailability and faster onset of action, demonstrating potential application in treating HSDD.
Review
Plant Sciences
Mariana Colombo, Luana Roberta Michels, Helder Ferreira Teixeira, Leticia Scherer Koester
Summary: The poor water solubility of flavonoids is a challenge, but can be improved through the use of solid dispersions (SD). Studies commonly use the solvent evaporation method with polyvinylpyrrolidone as a carrier, and have shown that SD is an excellent alternative to enhance solubility, dissolution, and oral bioavailability of flavonoids.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Phuong Tran, Thu Nhan Nguyen, Jeong-Sook Park
Summary: This study aimed to improve the dissolution and oral bioavailability of celecoxib (CXB) by preparing a co-carrier-based solid dispersion (SD). The CXB-loaded SD formulation consisted of CXB, pol407, Aerosil 200, and Eudragit L100 at a specific weight ratio. The results showed that the optimized CXB-SD had significantly higher dissolution efficiency compared to raw CXB, and its bioavailability was also improved. In conclusion, SDs can enhance the dissolution and oral bioavailability of poorly water-soluble CXB.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sathish Dharani, Eman M. Mohamed, Tahir Khuroo, Ziyaur Rahman, Mansoor A. Khan
Summary: This study aimed to improve the physicochemical properties and oral bioavailability of dasatinib by using the amorphous solid dispersion approach. The results showed that the ASD formulation significantly increased dissolution and oral bioavailability compared to the physical mixture.
Article
Instruments & Instrumentation
Debadatta Mohapatra, Dulla Naveen Kumar, Singh Shreya, Vivek Pandey, Pawan K. K. Dubey, Ashish Kumar Agrawal, Alakh N. Sahu
Summary: This study aimed to improve the solubility, dissolution, and oral bioavailability of standardized Piper longum fruits ethanolic extract (PLFEE) through fourth-generation ternary solid dispersion (SD) for melanoma therapy. The optimized SD showed good stability, high yield, and improved dissolution profile compared to the plain PLFEE. The in vivo oral bioavailability of SD demonstrated a significant improvement in bioavailability and the SD also enhanced the anticancer activity of dacarbazine (DTIC) as an adjuvant therapy. The developed SD has the potential for melanoma therapy either alone or in combination with DTIC.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Polymer Science
Arif Budiman, Annisa Luthfiyah Handini, Mutia Nur Muslimah, Neng Vera Nurani, Eli Laelasari, Insan Sunan Kurniawansyah, Diah Lia Aulifa
Summary: Improving the solubility of anticancer drugs for oral administration is crucial for enhancing their efficacy and safety. Amorphous solid dispersion (ASD) is a promising approach to increase the aqueous solubility and bioavailability of poorly water-soluble drugs. This study summarizes and elucidates the mechanisms and impact of the ASD system on cancer therapy, providing a comprehensive overview and discussion of related issues.
Article
Pharmacology & Pharmacy
Phuong Tran, Jeong-Sook Park
Summary: Dexibuprofen-loaded solid dispersion (SD) was formulated to improve solubility and bioavailability, with results demonstrating excellent potential for the SD formulation as a solution for poorly soluble drug Dexibuprofen.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhiwei Liang, Min Chen, Yuanyuan Yan, Dongmei Chen, Shuyu Xie
Summary: ABZ nanocrystals prepared using a bottom-up method showed improved solubility and oral bioavailability, suggesting a promising approach for enhancing the effectiveness of ABZ and other insoluble drugs.
Review
Pharmacology & Pharmacy
Aman Gupta, Gourav Paudwal, Rigzin Dolkar, Shaila Lewis, Prem N. Gupta
Summary: The oral route is the preferred method of drug administration due to its advantages such as cost-effectiveness and improved patient compliance. However, poor solubility and low bioavailability are common problems for new molecules in the drug discovery process. Solid dispersion (SD) has been widely used to address these issues and improve drug performance. Various polymers are currently used to prepare SDs for immediate or controlled release, and the choice of polymer and preparation method greatly affects the biological behavior of the SDs.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Acoustics
Melanie Girard, Francois Bertrand, Jason R. Tavares, Marie-Claude Heuzey
Summary: This study investigates the ultrasonication process of CNCs using rheology, comparing the dispersion states of suspensions with different concentrations. The findings provide insights on how to control the dispersion of CNCs effectively.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yue Ji, D. Eric Shen, Yang Lu, Gregory T. T. Schueneman, Meisha L. L. Shofner, J. Carson Meredith
Summary: Multilayer films consisting of nanocellulose and nanochitinasoxygen barrier coatings and a conventional petroleum-based moisturebarrier plastic as the substrate have been widely studied for foodpackaging applications. A study was conducted on multilayer films consisting of poly(ethyleneterephthalate) (PET) as a model substrate with chitin nanowhiskers(ChNWs) and cellulose nanocrystals (CNCs) as bilayer barrier coatings. A method for coating removal was proposed using dissolution in aqueous media at different pH values. The study demonstrated increased oxygen permeability (OP) with recycled CNC and ChNW coatings, suggesting a more sustainable solution for food packaging production.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Engineering, Chemical
Haiyun Tian, Zhiguo Qin, Guoliang Wang, Xinxin Yu, Jiadong Chen, Zhiquan Lin, Shanshan Du, Haipeng Yin, Huibin Zou, Tao Liu
Summary: This study investigated the effects of dissolution medium on the dissolution of pH dependent nanocrystals and solubilizer related nanocrystals under sink and non-sink conditions. It was found that particle size and solubilizer concentration play a significant role in the dissolution process, with dissolution divided into two phases under non-sink conditions.
Article
Pharmacology & Pharmacy
Wan Liu, Meng Cheng, Fangying Yuan, Jiaying He, Yulin Feng, Yi Jin, Jianfang Feng, Shilin Yang, Liangxing Tu
Summary: Nanocrystal technology is commonly used to improve the oral bioavailability of poorly-soluble drugs. This study focused on enhancing oral absorption through nanocrystals and utilized SDS-TPGS to modify andrographolide nanocrystals (S-TANs). The results showed that the particle sizes of modified nanocrystals were larger than that of physical mixtures, and nanocrystals improved the solubility and absorption of andrographolide. Additionally, the copolymer modified nanocrystals exhibited higher enhancing ability than physical mixtures. Overall, functional stabilizer modification is an efficient strategy to enhance the oral bioavailability of nanocrystals.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Yao Liu, Yong Zhang, Qiuli Yan, Xueping Zhong, Chunhui Hu
Summary: By using solid dispersion technology, the triblock copolymer PEO-PPO-PEO P188 can make the poorly water-soluble drug paclitaxel exist in an amorphous state, significantly improving its release rate and enhancing its oral bioavailability.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Vishwas P. Pardhi, Keerti Jain
Summary: The study demonstrates that the preparation of BDQN solid dispersions can significantly enhance saturation solubility and in vitro dissolution performance, with TSD showing better stability under accelerated conditions and potential benefits for the treatment of patients with multidrug-resistant tuberculosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)