Article
Immunology
Rewaida Abdel-Gaber, Maysar Abu Hawsah, Tahani Al-Otaibi, Ghada Alojayri, Esam M. Al-Shaebi, Osama B. Mohammed, Manal F. Elkhadragy, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The study aimed to determine whether biosynthesized selenium nanoparticles (Bio-SeNPs) using Azadirachta indica leaves extract could treat mice with Eimeria papillata infection in the jejunal tissue. The results showed that Bio-SeNPs significantly reduced the oocyst output in mice feces and the number of developmental parasitic stages in the jejunal tissues. Additionally, Bio-SeNPs lowered oxidative stress and inflammatory indicators, protecting the mice against jejunal damage caused by infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Mutee Murshed, Jameel Al-Tamimi, Hossam M. A. Aljawdah, Saleh Al-Quraishy
Summary: A study was conducted to evaluate the effects of Vitis vinifera leaf extract on inflammation, oxidative status, and goblet cell response against Eimeria papillate infection in mice. The results showed that the extract had anti-inflammatory properties and reduced the number of parasite stages, demonstrating its significant anticoccidial effects in vivo.
Article
Biochemistry & Molecular Biology
Junying Xiao, Na Li, Shengze Xiao, Yuzhou Wu, Hongmei Liu
Summary: This study demonstrated that chitosan-stabilized selenium nanoparticles (CS-SeNPs) and Na2SeO3 have significant anti-atherosclerotic activity in a high-fat-diet-fed mouse model of atherosclerosis. They were found to alleviate vascular endothelial dysfunction and inflammation, leading to reduced atherosclerotic lesions in mouse aortae. Importantly, CS-SeNPs showed potential for atherosclerosis prevention with lower toxicity compared to Na2SeO3. These findings suggest that selenium supplementation may be a promising therapeutic strategy for atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Asif Raza, Hannah Johnson, Amandeep Singh, Arun K. Sharma
Summary: The ability to develop novel medications based on nanoscale complexes, such as selenium nanoparticles (SeNPs), has significantly enhanced the capabilities of current pharmaceuticals and has shown promise in controlling inflammation and fighting diseases caused by chronic inflammation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Agriculture, Multidisciplinary
Hong Chen, Gengan Du, Xiaohai Yan, Huanfeng Ye, Qi Guo, Zhouli Wang, Yahong Yuan, Tianli Yue
Summary: This study investigated the protective effects of a selenium-enriched strain, SeP, on jejunum injuries induced by PAT. The results showed that SeP could alleviate PAT-induced intestinal damage and inflammation, as well as regulate the intestinal microbiota. These findings suggest that SeP may serve as a novel protective agent against the toxicity of PAT.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Ran Wang, Md Moniruzzaman, Kuan Yau Wong, Percival Wiid, Alexa Harding, Rabina Giri, Wendy (Hui) Tong, Jackie Creagh, Jakob Begun, Michael A. McGuckin, Sumaira Z. Hasnain
Summary: The study found that microbiota plays a role in the development of Winnie colitis but is not essential, as protein misfolding can directly trigger inflammation in the absence of microbiota.
Article
Biochemistry & Molecular Biology
Barakat M. Alrashdi, Alaa Fehaid, Rami B. Kassab, Sara Rizk, Ola A. Habotta, Ahmed Abdel E. Moneim
Summary: This study aimed to investigate the potential anti-seizure effect of EGCG-SeNPs. The results showed that administration of EGCG-SeNPs exhibited anti-epileptic activity by increasing latency time and reducing seizure duration. Moreover, EGCG-SeNPs demonstrated anti-inflammatory, anti-apoptotic, and neuromodulatory effects.
Article
Biology
Abdulsalam Alkhudhayri, Felwa A. Thagfan, Saleh Al-Quraishy, Rewaida Abdel-Gaber, Mohamed A. Dkhil
Summary: Magnesium nanoparticles show therapeutic effects on mice infected with Eimeria papillata by affecting intestinal cells through their anti-oxidative properties and regulatory effects on mucin genes.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rosa Martha Perez Gutierrez, Julio Tellez Gomez, Raul Borja Urby, Jose G. Contreras Soto, Hector Romo Parra
Summary: This study aimed to investigate the role of a combination of luteolin and diosmin in selenium nanoparticles (SeNPs) in streptozotocin-induced diabetes mice. The results showed that the SeNPs nanospheres prepared by a high-efficiency strategy could improve the efficiency in type 2 diabetes by restoring blood glucose, lipid profile, and exhibiting good antioxidant activity.
Article
Biochemistry & Molecular Biology
Xuan Wang, Bin Yang, Hui-Li Cao, Rui-Ying Wang, Zhao-Yang Lu, Rui-Fang Chi, Bao Li
Summary: Selenium pretreatment has protective effects on LPS-induced myocardial injury by improving myocardial damage and dysfunction, reducing inflammation, oxidative stress, and myocardial apoptosis, as well as inactivating the Sting pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Shubin Li, Xingna Dong, Limeng Xu, Zhenli Wu
Summary: This study investigated the potential effects of selenium nanoparticles (SeNPs) on arsenic exposure-induced nephrotoxicity. The results showed that SeNPs could alleviate fibrosis, inflammation, oxidative stress-related damage, and apoptosis caused by sodium arsenite (NaAsO2) exposure in mice and renal tubular duct epithelial cells (HK2 cells).
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
Rami B. Kassab, Mohamad Elbaz, Atif A. A. Oyouni, Ahmad H. Mufti, Abdulrahman Theyab, Ashraf Al-Brakati, Hala A. Mohamed, Ali M. S. Hebishy, Mohammed I. Y. Elmallah, Mohamed S. Abdelfattah, Ahmed E. Abdel Moneim
Summary: The study found that loading selenium nanoparticles onto prodigiosins could protect against acetic acid-induced UC in rats by reducing colon inflammation and mucosal damage, improving colon's antioxidant capacity, and preventing oxidative stress, as well as protecting intestinal cells from apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shu-Jiang Peng, Da-Tian Ye, Jie Zheng, Ya-Ru Xue, Lin Lin, Ya-Dong Zhao, Wen-Hua Miao, Yan Song, Zheng-Shun Wen, Bin Zheng
Summary: In this study, a new form of selenium nanoparticle, LCS-SeNPs, was synthesized and characterized. The results showed that LCS-SeNPs protected against colon injury and inflammation, improved intestinal barrier dysfunction, and alleviated oxidative stress. Moreover, LCS-SeNPs achieved these effects through the regulation of NF-kappa B and Nrf2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Vinod Gangadevi, Sowjanya Thatikonda, Venkatesh Pooladanda, Geetanjali Devabattula, Chandraiah Godugu
Summary: Selenium nanoparticles induce cell apoptosis by generating reactive oxygen species, significantly alleviating the severity of psoriasis. Furthermore, SeNPs can inhibit various inflammation and proliferation pathways.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elena G. Varlamova, Egor A. Turovsky, Ekaterina V. Blinova
Summary: The review highlights the importance of selenium nanoparticles in human health and medicine, detailing their production methods and the potential for creating new drugs or enhancing existing ones. Selenium, a key component in antioxidant enzymes, has been extensively studied in recent years, with a focus on its potential applications in medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Abdulsalam Alkhudhayri, Ahmed E. Abdel Moneim, Sara Rizk, Amira A. Bauomy, Mohamed A. Dkhil
Summary: Echinops spinosus is a medicinal plant with various pharmacological effects, including antioxidant, anti-inflammatory, and antibacterial properties. This study found that E. spinosus extract has neuroprotective and anticonvulsant characteristics, reducing seizure duration and preventing cell death. It also showed potential as a natural anticonvulsant.
NEUROCHEMICAL RESEARCH
(2023)
Article
Environmental Sciences
Mona A. Ibrahim, Sherif R. Mohamed, Mohamed A. Dkhil, Felwa A. Thagfan, Rewaida Abdel-Gaber, Doaa Soliman
Summary: The aim of this study was to evaluate the therapeutic anticancer role of Moringa oleifera leaf extracts (MLE) in urethane-induced lung cancer in male albino rats. Results showed that MLE treatment reduced lung index, improved oxidative stress markers, and increased EGFR-mRNA expression. Furthermore, MLE decreased collagen fiber distribution and tumor mass, leading to restoration of normal lung histology. These findings suggest that MLE may serve as an alternative treatment for lung cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Veterinary Sciences
Mona Saleh, Abdel-Azeem S. Abdel-Baki, Mohamed A. Dkhil, Mansour El-Matbouli, Saleh Al-Quraishy
Summary: The study demonstrates the crucial role of heat shock protein 90 (HSP90) in the growth and development of Ichthyophthirius multifiliis, suggesting it as a potential therapeutic target. By using antisense oligonucleotides to knock down the HSP90 gene, it was shown that the growth and development of the parasite were significantly limited, and the infectivity of treated parasites was reduced in fish.
BMC VETERINARY RESEARCH
(2023)
Article
Anatomy & Morphology
Rewaida Abdel-Gaber, Maysar Abu Hawsah, Esam M. Al-Shaebi, Tahani Al-Otaibi, Felwa A. Thagfan, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The biosynthesized nano-selenium from Azadirachta indica leaf extracts (BNS) showed promising therapeutic effects against Eimeria papillata-induced infection in mice. It not only suppressed the oocyst output by 97.21% but also improved feed intake and exhibited antioxidant activity. BNS could be a potential treatment for coccidiosis.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Immunology
Rewaida Abdel-Gaber, Maysar Abu Hawsah, Tahani Al-Otaibi, Ghada Alojayri, Esam M. Al-Shaebi, Osama B. Mohammed, Manal F. Elkhadragy, Saleh Al-Quraishy, Mohamed A. Dkhil
Summary: The study aimed to determine whether biosynthesized selenium nanoparticles (Bio-SeNPs) using Azadirachta indica leaves extract could treat mice with Eimeria papillata infection in the jejunal tissue. The results showed that Bio-SeNPs significantly reduced the oocyst output in mice feces and the number of developmental parasitic stages in the jejunal tissues. Additionally, Bio-SeNPs lowered oxidative stress and inflammatory indicators, protecting the mice against jejunal damage caused by infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Rewaida Abdel-Gaber, Masheil Alghamdi, Saleh Al Quraishy, Esam M. Al-Shaebi, Manal F. Elkhadragy, Saeed El-Ashram, Mohamed A. Dkhil
Summary: Fish products are a significant source of animal protein but can also contain various parasites, including monogeneans. This study focused on the monogenean parasites infecting the soldier bream Argyrops filamentosus from the Red Sea coast of Jeddah, Saudi Arabia. One species, Haliotrema susanae, was found to infect 50% of the investigated fish species. This study provides the first report of Haliotrema species as ectoparasites of sparid fish and adds a new genetic sequence for this parasite species.
Article
Multidisciplinary Sciences
Hanadi B. Baghdadi, Rewaida Abdel-Gaber, Saleh Al Quraishy, Marwa M. Abou Hadied, Tahani Al-Otaibi, Manal F. Elkhadragy, Esam M. Al-Shaebi, Mohamed Dkhil
Summary: The focus of this study was to examine the potential parasites' ability to serve as bio-indicators of pollution in marine ecosystems. Forty samples of the king soldier bream were collected from the Red Sea for this purpose. Only 25 fish samples were found to be infected with a nematode parasite, Hysterothylacium reliquens, and the levels of certain metals were detected in both the parasite stages and the fish host tissues. The study revealed that fish nematodes could be helpful bioindicators for assessing heavy metal contamination in aquatic ecosystems.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Felwa A. Thagfan, Mohamed A. Dkhil, Esam M. Al-Shaebi, Rewaida Abdel-Gaber, Saleh Al-Quraishy, Sherif Elshanat
Summary: This study compared the response of the liver to induced coccidiosis on treatment with nanosilver synthesized from Zingiber officinale (NS) and the reference anticoccidial drug amprolium in Eimeriapapillate-infected mice. The results showed that NS was able to inhibit the sporulation of E. papillate by approximately 73% and improve the liver function in mice. Treatment with NS also improved the parasite-induced liver histological injury and increased the levels of glutathione and glutathione peroxidase. Overall, NS outperformed amprolium in E. papillata-induced mice.
Article
Multidisciplinary Sciences
Doaa Soliman, Mona A. Ibrahim, Sherif R. Mohamed, Felwa A. Thagfan, Manal F. El-khadragy, Wafa A. Al-Megrin, Murad A. Mubaraki, Mohamed A. Dkhil
Summary: The study aims to evaluate the antitumor effect of propolis extract (PE) against urethane-induced lung cancer compared to Cisplatin (CIS) in rats. Various tests and analyses were conducted, which indicated that PE can improve oxidative stress, gene expression, and histopathology caused by urethane, and increase the expression of EGFR-mRNA. Furthermore, PE can reduce abnormal collagen fiber distribution, papillary adenocarcinoma growth, bronchial wall thickening, inflammation, and alveolar collapse. Therefore, PE can be considered as an excellent source of natural chemicals that fight lung cancer.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Veterinary Sciences
A. S. Fathalla, M. A. Ibrahim, S. R. Mohamed, M. A. Dkhil, F. A. Thagfan, R. Abdel-Gaber, D. Soliman
Summary: This study evaluated the anticancer performance of Cassia alata methanolic leaf extracts (CMLE) in ethyl carbamate-stimulated lung adenocarcinoma (LAD) and compared it with the function of Cisplatin (CIPL). The results showed that CMLE treatment had a good anticancer effect with less toxicity compared to Cisplatin.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2023)
Article
Parasitology
Tahani Al-Otaibi, Maysar Abu Hawsah, Ghada Alojayri, Mohammed M. Mares, Hossam M. A. Aljawdah, Saleh N. Maodaa, Esam M. Al-Shaebi, Mohamed A. Dkhil, Felwa A. Thagfan, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: This study evaluated the anticoccidial activity of Persea americana fruit extract (PAFE) in mice and found that the 500 mg/kg dose was the most effective in reducing oocyst output and parasite stages, while increasing goblet cell count. PAFE also showed antioxidant and anti-inflammatory activities, making it a promising treatment for coccidiosis.
PARASITOLOGY INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Murad A. A. Mubaraki, Hussain A. A. Almuayrifi, Taghreed A. Hafiz, Abdulaziz Alyousef, Mohamed A. A. Dkhil, Felwa A. A. Thagfan, Rewaida Abdel-Gaber, Mohammad A. A. Al-Najjar, Abdulsalam Alkhudhayri, Sherif Elshanat
Summary: This study evaluated the prevalence and trends of transfusion-transmitted infections (TTIs) in two hospitals in Riyadh and determined the best type of tests to ensure blood transfusion safety. Serological and nucleic acid tests (NAT) were performed on blood donors to screen for various infections. The study revealed the seriousness of the residual risk of TTI and suggested that utilizing NAT could improve blood safety and be cost-effective.
Article
Environmental Sciences
Mohamed A. Dkhil, Felwa A. Thagfan, Mostafa Y. Morad, Esam M. Al-Shaebi, Sherif Elshanat, Amira A. Bauomy, Murad Mubaraki, Taghreed A. Hafiz, Saleh Al-Quraishy, Rewaida Abdel-Gaber
Summary: This study investigates the action of silver nanoparticles prepared from Zingiber officinale rhizomes in the treatment of mice infected with Eimeria papillata. The results demonstrate that the nanoparticles can improve the jejunal mucosa and reduce the pathological damage associated with the infection.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)