期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ijms19071947
关键词
Alzheimer's disease; yeast; Tau; amyloid beta; ubiquitin; aggregation; oligomerization; prion
资金
- Aspirant fellowship of Research Foundation-Flanders (FWO) [1101317N]
- FWO [1287517N]
- FWO SBO Fellowship [1S80418N]
- FWO SBO [S006617N]
- KU Leuven
- University of Kent
- Biotechnology and Biological Sciences Research Council
In this review article, yeast model-based research advances regarding the role of Amyloid-beta (A beta), Tau and frameshift Ubiquitin UBB+1 in Alzheimer's disease (AD) are discussed. Despite having limitations with regard to intercellular and cognitive AD aspects, these models have clearly shown their added value as complementary models for the study of the molecular aspects of these proteins, including their interplay with AD-related cellular processes such as mitochondrial dysfunction and altered proteostasis. Moreover, these yeast models have also shown their importance in translational research, e.g., in compound screenings and for AD diagnostics development. In addition to well-established Saccharomyces cerevisiae models, new upcoming Schizosaccharomyces pombe, Candida glabrata and Kluyveromyces lactis yeast models for A beta and Tau are briefly described. Finally, traditional and more innovative research methodologies, e.g., for studying protein oligomerization/aggregation, are highlighted.
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