Review
Plant Sciences
Jumoke A. Aboyewa, Nicole R. S. Sibuyi, Mervin Meyer, Oluwafemi O. Oguntibeju
Summary: The application of metallic nanoparticles, especially biogenically synthesized ones using natural materials like plants, has transformed the field of medicine. South Africa, with about 10% of the world's plant species, plays a crucial role in synthesizing these nanoparticles. Utilizing African plant biodiversity for nanomedicine has great potential for future applications.
Article
Multidisciplinary Sciences
Nouf M. Al-Enazi, Khawla Alsamhary, Fuad Ameen, Mansour Kha
Summary: In this study, cobalt-doped zinc oxide nanoparticles were successfully synthesized using the green synthesis method. The cytotoxicity and antimicrobial effects of the synthesized nanoparticles were investigated, and it was found that cobalt doping led to a slight decrease in particle size and an increase in toxicity.
Article
Chemistry, Multidisciplinary
Farahnaz Behzad, Seyed Morteza Naghib, Mohammad Amin Jadidi Kouhbanani, Seyede Nafise Tabatabaei, Yasser Zare, Kyong Yop Rhee
Summary: Metallic nanoparticles, especially noble metal nanoparticles such as silver, gold, and platinum, have attracted research interest for their excellent properties and diverse applications, particularly in antimicrobial fields. Green approaches using plant extracts for producing nanoparticles offer novel antimicrobial features to address microbial contaminations in various industries. The development of noble metal nanoparticles aims to resolve existing toxicity concerns and explore their antimicrobial effects, facing future challenges in this field.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Environmental Sciences
Ali Ahmad, Syed Salman Hashmi, Jose M. Palma, Francisco J. Corpas
Summary: Nanotechnology has the potential to greatly influence plant physiology and agriculture. While nanoparticles (NPs) can improve crop production and nutrition, they may also have toxic effects on plants. Understanding the dynamics of nanoparticle toxicity in plants is crucial for agricultural sustainability and combating climate change.
Review
Biochemistry & Molecular Biology
Piyush Kumar Thakur, Varsha Verma
Summary: Cancer is a major cause of mortality worldwide, with challenges in clinical management due to side effects of traditional treatment. Nanotechnology shows promise in improving cancer treatment and drug development, offering potential for enhancing quality of life for humans.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heba M. Abdallah, Mahmoud H. Abu Elella, Marwa M. Abdel-Aziz
Summary: Tuberculosis (TB) is a highly lethal infectious disease. Traditional anti-TB drugs have limitations in terms of toxicity and treatment efficacy. In recent years, the development of new anti-TB drugs using natural biopolymers has gained attention due to their biodegradability, biocompatibility, and non-toxicity. This study successfully engineered chitosan biguanidine (ChBG) nanoparticles as a safe and effective anti-TB drug. The nanoparticles showed uniform distribution and a small particle size of approximately 38 nm. They exhibited significant inhibitory activity against different M. tuberculosis strains, including drug-resistant strains, with minimal inhibitory concentrations (MIC) lower than that of isoniazid. Furthermore, the ChBG nanoparticles showed no cytotoxicity against normal lung cells in the tested concentration range.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Samaneh Ghazal, Niloufar Khandannasab, Hasan Ali Hosseini, Zahra Sabouri, Abdolrasoul Rangrazi, Majid Darroudi
Summary: In this study, copper doping nickel oxide nanoparticles were synthesized using a sol-gel method with okra plant extract. The nanoparticles were characterized through various analyses, showing promising photocatalytic degradation of dye and low cytotoxicity towards cancer cells.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Mina Jamzad, Bahar Mokhtari, Pantea-Sadat Mirkhani
Summary: In this study, iron oxide (Fe3O4), cuprous oxide (Cu2O), and silver (Ag) nanoparticles were synthesized using a simple and green method mediated by the aqueous extract of Froriepia subpinnata. The synthesized nanoparticles were characterized and evaluated for their antimicrobial activity, as well as their potential for adsorbing the Azo dye Acid-Red 58. The Cu2O and Ag nanoparticles showed high effectiveness against the tested pathogenic microorganisms, while the aqueous extract of F. subpinnata exhibited growth inhibition of the A549 cell line. The synthesized Fe3O4 nanoparticles also showed satisfactory potential for adsorbing the Azo dye Acid-Red 58.
Review
Pharmacology & Pharmacy
Jabulile Happiness Xulu, Tanaka Ndongwe, Kenneth M. Ezealisiji, Vuyelwa J. Tembu, Nontobeko P. Mncwangi, Bwalya A. Witika, Xavier Siwe-Noundou
Summary: Theranostics, a tool capable of simultaneous detection and treatment of diseases, is gaining momentum in modern medicine. Medicinal plant-derived metallic nanoparticles (MNPs) have shown potential in the diagnosis and treatment of various diseases, including cancer, malaria, microbial, and cardiovascular diseases.
Review
Environmental Sciences
Jing Li, Chuanxi Wang, Le Yue, Feiran Chen, Xuesong Cao, Zhenyu Wang
Summary: Given the rapid development of nanotechnology, understanding the effects of nanoparticles on living organisms is crucial. Quantitative structure-activity relationship (QSAR) is an effective computational technique that saves time, costs, and animal sacrifice. This review presents general procedures for constructing and applying nano-QSAR models of metal-based and metal-oxide nanoparticles (MBNPs and MONPs), and reviews the roles of molecular descriptors in the toxicological interpretation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Polymer Science
Yingqi Mi, Jingjing Zhang, Lulin Zhang, Qing Li, Yuanzheng Cheng, Zhanyong Guo
Summary: Chitosan nanoparticles loaded with adriamycin exhibited a burst effect followed by steady release, and demonstrated enhanced antioxidant activities and cytotoxicities against cancer cells. With reduced cytotoxicity and enhanced biological activity, these novel nanoparticles could serve as promising candidates for drug loading/release in drug delivery systems.
Article
Biochemistry & Molecular Biology
Menghua Shi, Jie Deng, Jinying Min, Hanyu Zheng, Mengpei Guo, Xiaolin Fan, Shuiyuan Cheng, Shaopeng Zhang, Xiaolong Ma
Summary: In this study, Morchella sextelata polysaccharide (MSP) was used as a stabilizer for the synthesis of selenium nanoparticles (SeNPs). The synthesized MSP-SeNPs exhibited red color, spherical shape, and amorphous nature. They showed high scavenging activity against DPPH and ABTS radicals, and significant anti-proliferation effect on HepG2 and Hela cancer cells. The mitochondria-dependent apoptosis pathway was identified as the mechanism of action.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Yuan-Yun Zhao, Feng Qian, Wenfeng Shen, Chengliang Zhao, Jianguo Wang, Chunxiao Xie, Fengling Zhou, Chuntao Chang, Yanjun Li
Summary: The approach of synthesizing metal and alloy nanoparticles by ultrasound-assisted dealloying of metallic glasses without the use of reducing agents and surfactants simplifies the up-scaling synthesis process. The formation mechanism involves the glass-liquid phase transition and ultrasound-driven ligament-breakage effects. This method provides a general strategy for synthesizing unprecedented multimetallic nanoparticles.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Food Science & Technology
Bo Ao, Jing Lv, Hongmei Yang, Fei He, Yuanliang Hu, Bing Hu, Honglin Jiang, Xixiang Huo, Junming Tu, Xian Xia
Summary: In this study, biological selenium nanoparticles (Bio-SeNPs) synthesized by Moringa oleifera extract and selenite were used to inhibit Listeria monocytogenes and Corynebacterium diphtheriae. The results showed that these Bio-SeNPs exhibited significant antibacterial activity and could effectively inhibit the growth of both strains.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Maria P. Nikolova, Payal B. Joshi, Murthy S. Chavali
Summary: The development of eco-friendly nano assembly using biosynthesis has led to the production of metallic and metal oxide nanoparticles with various pharmaceutical applications. These biogenic nanoparticles have shown potential as tumoricidal, anti-inflammatory, antimicrobial, and antiviral agents. The review discusses the types of renewable biological systems used for biosynthesis and the role of biogenic nanoparticles as drug carriers. The review also highlights the impact of the biosystem on the morphology, size, shape, and structure of the produced nanomaterial, as well as the toxicity and recent advancements in enhancing biocompatibility and reducing side effects.
Article
Chemistry, Analytical
Rania Edrees Adam Mohammad, Abdalla Ahmed Elbashir, Jamilah Karim, Noorfatimah Yahaya, Nurul Yani Rahim, Mazidatulakmam Miskam
Summary: This study successfully removed fluoroquinolones (FQs) from aquatic systems using graphene oxide-based magnetic nanoparticles (GO@Fe3O4) as adsorbents. The results showed that GO@Fe3O4 adsorbent had high adsorption capacity and removal efficiency, indicating its potential as an alternative adsorbent.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Review
Biotechnology & Applied Microbiology
Syed Fariq Fathullah Syed Yaacob, Mamman Suwaibatu, Raja Zalinda Raja Jamil, Nur Nadhirah Mohamed Zain, Muggundha Raoov, Faiz Bukhari Mohd Suah
Summary: Cyclodextrins, composed of starch molecules, have toroidal structures with hydrophilic edges and hydrophobic cavities. They can form inclusion complexes and be used as functional monomers in imprinting technology. This study highlights the application of cyclodextrins in the remediation of phenolic compounds.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Analytical
Nur Farahin Mohd Ali, Muhammad Sajid, Wan Ibrahim Thani Abd Halim, Ahmad Husaini Mohamed, Nur Nadhirah Mohamad Zain, Sazlinda Kamaruzaman, Nor Suhaila Mohamad Hanapi, Wan Nazihah Wan Ibrahim, Noorfatimah Yahaya
Summary: Bisphenols in the natural environment have gained global attention due to their potential hazards to human health and the aquatic ecosystem. However, their trace-level presence makes the direct determination in food and water matrices challenging. Therefore, sensitive, effective, rapid, and simple extraction and concentration methods are required.
MICROCHEMICAL JOURNAL
(2023)
Review
Biochemical Research Methods
Siti Munirah Ishak, Noorfatimah Yahaya, Saw Hong Loh, Sazlinda Kamaruzaman, Nur Nadhirah Mohamad Zain, Maisarah Nasution Waras, Wan Nazwanie Wan Abdullah, Mazidatulakmam Miskam, Muggundha Raoov, Noorizan Abd Aziz, Yahaya Hassan
Summary: This review provides an overview of the extraction methods for saxitoxin, including conventional liquid-liquid extraction and solid-phase extraction, as well as the emerging microscale sample preparation method. Despite their tedious procedures, liquid-liquid extraction and solid-phase extraction remain the most commonly used techniques due to their high sensitivity and selectivity in detecting saxitoxin. However, microscale sample preparation offers potential as a green technique for the development of advanced adsorbents with better sensitivity.
Article
Chemistry, Analytical
Mohamad Shariff Shahriman, Sharifah Mohamad, Nur Nadhirah Mohamad Zain, Muggundha Raoov
Summary: A paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) film was developed for the extraction and analysis of multiple antibiotics in environmental water samples. The method showed good linearity, low detection limits, and high extraction recoveries. It offers advantages of small sample volume, fast extraction, and feasibility in daily analysis.
Article
Food Science & Technology
Ain Nabila Syahira Shamsol Azman, Jun Jie Tan, Muhammad Nazrul Hakim Abdullah, Hasnah Bahari, Vuanghao Lim, Yoke Keong Yong
Summary: This study utilized network pharmacology to assess the potential pharmacological effects of bioactive compounds in Tualang honey on atherosclerosis. The results showed that 6 compounds in Tualang honey had potential therapeutic effects on atherosclerosis, supporting its use as a promising treatment for the disease.
Article
Chemistry, Medicinal
Batoul Alallam, Abd Almonem Doolaanea, Mulham Alfatama, Vuanghao Lim
Summary: Zinc oxide nanoparticles (Green-ZnO-NPs) were prepared using pure curcumin and showed additive antimicrobial and anticancer effects with curcumin. The physicochemical properties of Green-ZnO-NPs were characterised, and their inhibitory effect on bacterial strains and cancer cells was evaluated. The results demonstrated that Green-ZnO-NPs have potential as an alternative therapeutic agent for cancer treatment.
Review
Polymer Science
Batoul Alallam, Hazem Choukaife, Salma Seyam, Vuanghao Lim, Mulham Alfatama
Summary: Kidney disease is a significant global burden, and drug delivery to the kidneys is challenging. Nanotechnology offers potential solutions, as nanomaterials with unique properties have shown promising potential in renal therapy. Various types of nanosystems have been developed to improve drug delivery to the kidneys, and this review discusses their features and strategies.
Article
Chemistry, Physical
Nor Munira Hashim, Musthahimah Mohamad, Nik Nur Syazni Nik Mohamed Kamal, Mohd Yusmaidie Aziz, Sharlina Mohamad, Noorfatimah Yahaya, Nur Nadhirah Mohamad Zain
Summary: In this study, new hydrophobic deep eutectic solvents (HDES) were successfully prepared and functionalized onto magnetic nanoparticles as an efficient adsorbent for diclofenac and ibuprofen. The cytocompatibility study indicated that HDES offers new possibilities for safe distribution and application.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Analytical
Dyia Syaleyana Md Shukri, Noorfatimah Yahaya, Mazidatulakmam Miskam, Rizana Yusof, Ahmad Husaini Mohamed, Sazlinda Kamaruzaman, Nur Nadhirah Mohamad Zain, Nadhiratul-Farihin Semail
Summary: Misuse and incorrect disposal of fluoroquinolones (FQs) have resulted in environmental pollution and contamination of FQs in food chains. As a result, researchers have been striving to develop innovative and simple techniques for FQs analysis in real samples, with a focus on micro- and macroscale dispersive solid-phase extraction (DSPE). Recent studies have reported the use of DSPE-based techniques for sample preparation and detection of FQs in various matrices. This study summarizes current FQs detection methods using chromatographic and DSPE-based combinations, and evaluates the advantages and analytical performance of DSPE in detecting trace levels of FQs.
MICROCHEMICAL JOURNAL
(2023)
Article
Polymer Science
Ghufran Ullah, Asif Nawaz, Muhammad Shahid Latif, Kifayat Ullah Shah, Saeed Ahmad, Fatima Javed, Mulham Alfatama, Siti Aisyah Abd Ghafar, Vuanghao Lim
Summary: Bilayer/multilayer tablets are commonly used to tailor drug release, and this research aimed to formulate a novel gastro-retentive tablet to eliminate H. pylori in the gastrointestinal tract. Bilayer tablets were prepared using the direct compression technique, and the controlled-release bilayer tablets were prepared using hydrophilic swellable polymers (sodium alginate, chitosan, and HPMC-K15M). The study concluded that the combination of sodium alginate, chitosan, and HPMC polymers resulted in a gastro-retentive and controlled-release drug delivery system.
Article
Chemistry, Analytical
S. Mamman, S. F. F. S. Yaacob, M. Raoov, F. S. Mehamod, N. N. M. Zain, F. B. M. Suah
Summary: This study evaluated the removal of bisphenol A (BPA), 2,4-dinitrophenol (2,4-DNP), and 2,4-dichlorophenol (2,4-DCP) using a new magnetic adsorbent methacrylic acid-functionalized beta-cyclodextrin (Fe3O4@MAA-beta CD). The materials were characterized and various operational parameters were optimized. The result showed that 2,4-DNP had the highest affinity towards the adsorbent, and BPA was used as a model analyte for further study. The adsorption followed pseudo-second order kinetics and Freundlich and Halsey isotherms fitted the equilibrium data.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Ahmad Husaini Mohamed, Nur Athirah Noorhisham, Noorfatimah Yahaya, Sharifah Mohamad, Sazlinda Kamaruzzaman, Hasnah Osman, Hassan Y. Aboul-Enein
Summary: Despite the benefits of organophosphorus pesticides (OPPs) in controlling diseases and insects, their accumulation in the soil system can pose a serious threat to ecosystems and human health. It is crucial to isolate and preconcentrate OPPs from the soil matrix to achieve reliable detection due to low residue levels and the complexity of the soil. Sample preparation techniques have been reported to improve analytical measurements, including recovery, precision, detection limit, and quantification limit. The efficiency of extraction depends on the interaction between OPPs and the extraction media.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)