Article
Geriatrics & Gerontology
Hiromi Sano, Atsushi Nambu
Summary: ZNS is an anticonvulsant drug that has beneficial effects on Parkinson's disease and its side effect, L-DOPA-induced dyskinesia, but can also have adverse effects.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Zhihua Liu, Aijuan Yan, Jiahao Zhao, Shuyuan Yang, Lu Song, Zhenguo Liu
Summary: The study revealed the important role of p75NTR in patients with Parkinson's disease and suggested it as a new target for managing L-dopa-induced dyskinesia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. H. Greig, Jin Jung, Ho- Choi, Lars Olson, Barry J. J. Hoffer, Kuan-Yin Tseng
Summary: This study evaluated the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors and neurochemistry in a progressive Parkinson's disease MitoPark mouse model. The results showed that early administration of PT320 significantly reduced the severity of L-DOPA-induced abnormal involuntary movements, particularly in excessive standing and abnormal paw movements. However, late administration of PT320 did not improve any L-DOPA-induced dyskinesia measurements. Furthermore, early treatment with PT320 increased both tonic and phasic release of dopamine in striatal slices, indicating its potential role in alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Article
Neurosciences
Kuan-Yin Tseng, Tung-Tai Kuo, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Lars Olson, Barry J. Hoffer, Yuan-Hao Chen
Summary: The study demonstrates that TBZ attenuates abnormal striatal DA transmission and mitigates aberrant release of exogenous L-DOPA through modulating presymptomatic dynamics of DA. These findings support the potential of repositioning TBZ to counteract LID development.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
Changqing Zheng, Feng Zhang
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by motor symptoms, with L-DOPA being the most effective pharmacotherapy. However, L-DOPA can lead to motor fluctuations, including worsening symptoms and dyskinesia. Therefore, investigating the pathogenesis of LID and developing new interventions for its treatment are crucial in the management of PD.
Article
Neurosciences
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N. Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi
Summary: The striatum, the main structure of the basal ganglia, is subdivided into seven subregions with distinct roles in motor and emotional functions. Dopamine D1 receptor signaling is region-specifically regulated in the striatum, with aberrant activation in the IC associated with L-DOPA-induced dyskinesia. Future research focusing on D1 receptor signaling in the IC may lead to novel therapeutics for LID.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Feras Altwal, Fernando E. Padovan-Neto, Alexandra Ritger, Heinz Steiner, Anthony R. West
Summary: Research has shown that vilazodone may reduce dyskinesia in patients with Parkinson's disease without interfering with the prokinetic effects of L-DOPA, possibly through its action on 5-HT receptors.
Article
Immunology
Chang-Qing Zheng, Hong-Xia Fan, Xiao-Xian Li, Jing-Jie Li, Shuo Sheng, Feng Zhang
Summary: Resveratrol (RES) has shown potential in alleviating dyskinesia associated with Parkinson's disease treatment, reducing the abnormal movements induced by L-DOPA while protecting DA neurons from long-term damage, and inhibiting neuroinflammatory reactions mediated by glial cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Kai Yang, Xinyue Zhao, Changcai Wang, Cheng Zeng, Yan Luo, Taolei Sun
Summary: LID is a common issue in the treatment of Parkinson's disease, involving damage to multiple brain regions, with various theoretical models proposed to explain its mechanisms, necessitating a deeper understanding.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Maria Saez, Ettel Keifman, Samuel Alberquilla, Camila Coll, Ramon Reig, Mario Gustavo Murer, Rosario Moratalla
Summary: This study found that D2-type dopamine receptors and the striatopallidal pathway play important roles in modulating dyskinesia, and suggest that targeting striatopallidal axon terminals at the GPe may have therapeutic potential in the management of LID.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Sara Corsi, Simona Scheggi, Alessandra Pardu, Giulia Braccagni, Donatella Caruso, Lucia Cioffi, Silvia Diviccaro, Mauro Gentile, Silvia Fanni, Roberto Stancampiano, Carla Gambarana, Roberto Cosimo Melcangi, Roberto Frau, Manolo Carta
Summary: Research suggests a link between imbalances in the neurosteroid pathway and Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs). Specifically, the neurosteroid pregnenolone has been shown to counter LIDs and has similar effects to the 5 alpha-reductase inhibitor dutasteride. This study highlights pregnenolone as a potential novel tool for targeting LIDs in PD.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Physiology
Ana E. Speck, Aderbal S. Aguiar Jr, Samira G. Ferreira, Henrique B. Silva, Angelo R. Tome, Paula Agostinho, Rodrigo A. Cunha, Rui D. Prediger
Summary: In experimental murine models of LID, physical exercise can reduce abnormal corticostriatal neuroplasticity, alleviate the severity of LID.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Cell Biology
Brik A. Kochoian, Cassandra Bure, Stella M. Papa
Summary: A lot of research has been focused on therapeutic strategies for controlling L-DOPA-induced dyskinesias (LIDs) in Parkinson's disease. The only FDA-approved treatment for LIDs is amantadine, but there is a need for novel therapies with improved pharmacological profiles.
Article
Pharmacology & Pharmacy
Clarissa A. Pisano, Daniela Mercatelli, Martina Mazzocchi, Alberto Brugnoli, Ilaria Morella, Stefania Fasano, Nurulain T. Zaveri, Riccardo Brambilla, Gerard W. O'Keeffe, Richard R. Neubig, Michele Morari
Summary: The study indicates that RGS4 physiologically inhibits NOP receptor signaling and the chemical probe CCG-203920 can enhance NOP responses and improve the antidyskinetic potential of NOP receptor agonists.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Kim-Ann Saal, Dagmar Galter, Sigrun Roeber, Mathias Baehr, Lars Toenges, Paul Lingor
Article
Neurosciences
Richard Andersson, Dagmar Galter, Daniela Papadia, Andre Fisahn
Article
Clinical Neurology
Caroline Ran, Karin Wirdefeldt, Lovisa Brodin, Mehrafarin Ramezani, Marie Westerlund, Fengqing Xiang, Anna Anvret, Thomas Willows, Olof Sydow, Anders Johansson, Dagmar Galter, Per Svenningsson, Andrea Carmine Belin
PARKINSONS DISEASE
(2017)
Article
Neurosciences
Diego Luis-Ravelo, Hector Estevez-Silva, Pedro Barroso-Chinea, Domingo Afonso-Oramas, Josmar Salas-Hernandez, Julia Rodriguez-Nunez, Abraham Acevedo-Arozena, Daniel Marcellino, Tomas Gonzalez-Hernandez
EXPERIMENTAL NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Allissa A. Dillman, Elisa Majounie, Jinhui Ding, J. Raphael Gibbs, Dena Hernandez, Sampath Arepalli, Bryan J. Traynor, Andrew B. Singleton, Dagmar Galter, Mark R. Cookson
SCIENTIFIC REPORTS
(2017)
Letter
Neurosciences
Bruno Lima Giacobbo, Tomas Mediavilla, Daniel J. Marcellino, Fahad Sultan
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Neurosciences
Haian Mao, Tomas Mediavilla, Hector Estevez-Silva, Daniel Marcellino, Fahad Sultan
Summary: Motor learning induces plasticity in the brain, particularly in the cerebellum. This study focuses on the synaptic plasticity in the deep cerebellar nuclei (DCN) during motor learning. The researchers found that the increase in vGluT2 expression in a specific part of the DCN during skilled reaching tasks is due to an increase in co-expression of vGluT2 in vGluT1 presynapses, rather than the formation of new vGluT2 synapses. These findings suggest that synaptic remodeling plays an important role in motor learning.
Article
Neurosciences
Hector M. Estevez-Silva, Tomas Mediavilla, Bruno Lima Giacobbo, Xijia Liu, Fahad R. Sultan, Daniel J. Marcellino
Summary: This study investigated the disease-modifying effects of pridopidine in a SOD1 G93A mouse model of ALS. The results showed that pridopidine can modify ALS-associated cachexia and motor deficits, but did not extend the survival of the animals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Bruno Lima Giacobbo, Oezguen oezalay, Tomas Mediavilla, Madelene Ericsson, Jan Axelsson, Anna Rieckmann, Fahad Sultan, Daniel Marcellino
Summary: This study investigates changes in dopamine receptor availability and gray matter density in the striatum during aging in mice. Longitudinal imaging in mice can serve as a model for normal brain aging, complementing cross-sectional research in humans. The findings suggest that a natural loss of dopaminergic D-2 receptors in the striatum can be assessed in mice, reflecting estimates from humans. However, the tracer used for imaging D-1 receptors in mice may not yet replicate human findings.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Hector M. Estevez-Silva, German Cuesto, Ninovska Romero, Jose Miguel Brito-Armas, Abraham Acevedo-Arozena, Angel Acebes, Daniel J. Marcellino
Summary: Sigma-1 receptor agonists ACR16 and PRE-084 have been shown to promote the formation of new synapses and dendritic spines in vitro, while also exhibiting neuroprotective effects against oxidative stress and excitotoxicity. In an APP/PS1 mouse model, ACR16 improved spatial learning and memory deficits through activation of the PI3K/Akt pathway.
Article
Biology
Tomas Mediavilla, Ozgun Ozalay, Hector M. Estevez-Silva, Barbara Frias, Greger Oradd, Fahad R. Sultan, Claudio Brozzoli, Benjamin Garzon, Martin Lovden, Daniel J. Marcellino
Summary: Observations in rodents suggest that learning-dependent changes may involve increased dendritic spine density, alterations in astrocyte volume, and adaptations within intracortical myelin. Using a motor skill learning paradigm, this study found nonlinear increases in intracortical myelin during learning, supporting the hypothesis that myelin is a component of structural changes observed by voxel-based morphometry.
Article
Multidisciplinary Sciences
Nunya Chotiwan, Ebba Rosendal, Stefanie M. A. Willekens, Erin Schexnaydre, Emma Nilsson, Richard Lindqvist, Max Hahn, Ionut Sebastian Mihai, Federico Morini, Jianguo Zhang, Gregory D. Ebel, Lars-Anders Carlson, Johan Henriksson, Ulf Ahlgren, Daniel Marcellino, Anna K. Overby
Summary: The authors use a multimodal imaging-snRNAseq transcriptomics strategy to study the distribution of a neurotropic tick-borne flavivirus in the brain. They find that absence of interferon signaling increases infection of resident microglia. Using multimodal imaging and single nuclei RNA-sequencing, they visualize viral pathogenesis and define molecular mechanisms. The study highlights the importance of understanding viral tropism and the role of immune response in neurotropic flavivirus infection.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
B. Giacobbo, T. Mediavilla, J. Axelsson, M. Ericsson, D. Marcellino, F. Sultan
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Multidisciplinary Sciences
Shrikant S. Kolan, Tommy Lidstrom, Tomas Mediavilla, Andy Dernstedt, Sofie Degerman, Magnus Hultdin, Karl Bjork, Daniel Marcellino, Mattias N. E. Forsell
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Sandra Gellhaar, Dan Sunnemark, Hakan Eriksson, Lars Olson, Dagmar Galter
CELL AND TISSUE RESEARCH
(2017)