EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension

Prostanoid EP4 agonist L-902,688 activates PPARγ and attenuates pulmonary arterial hypertension

(2018) Hsin-Hsien Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Selectively targeting prostanoid E (EP) receptor-mediated cell signalling pathways: Implications for lung health and disease

(2018) Leonard F. Lebender et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Risk assessment, prognosis and guideline implementation in pulmonary arterial hypertension

(2017) Athénaïs Boucly et al.   EUROPEAN RESPIRATORY JOURNAL

An EP4 Receptor Agonist Inhibits Cardiac Fibrosis Through Activation of PKA Signaling in Hypertrophied Heart

(2017) Qi Wang et al.   International Heart Journal

The anti-inflammatory effects of PGE2on human lung macrophages are mediated by the EP4receptor

(2016) Sharonjit K Gill et al.   BRITISH JOURNAL OF PHARMACOLOGY

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

(2015) Nazzareno Galiè et al.   EUROPEAN HEART JOURNAL

The molecular targets of approved treatments for pulmonary arterial hypertension

(2015) Marc Humbert et al.   THORAX

Anti-inflammatory effects of PGE2in the lung: role of the EP4receptor subtype

(2015) Mark A Birrell et al.   THORAX

Propylthiouracil Attenuates Experimental Pulmonary Hypertension via Suppression of Pen-2, a Key Component of Gamma-Secretase

(2015) Ying-Ju Lai et al.   PLoS One

Iloprost reverses established fibrosis in experimental right ventricular failure

(2014) Jose Gomez-Arroyo et al.   EUROPEAN RESPIRATORY JOURNAL

Prostaglandin E 2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling

(2013) Utako Yokoyama et al.   CIRCULATION

Riociguat for the Treatment of Pulmonary Arterial Hypertension

(2013) Hossein-Ardeschir Ghofrani et al.   NEW ENGLAND JOURNAL OF MEDICINE

E-type prostanoid receptor 4 (EP4) in disease and therapy

(2013) Viktoria Konya et al.   PHARMACOLOGY & THERAPEUTICS

Pathobiology of pulmonary arterial hypertension and right ventricular failure

(2012) Norbert F. Voelkel et al.   EUROPEAN RESPIRATORY JOURNAL

Molecular pathogenesis of pulmonary arterial hypertension

(2012) Marlene Rabinovitch   JOURNAL OF CLINICAL INVESTIGATION

The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

(2012) Naoki Nakagawa et al.   KIDNEY INTERNATIONAL

The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats

(2012) Michaela Lang et al.   PLoS One

Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

(2011) Sonsoles Piera-Velazquez et al.   AMERICAN JOURNAL OF PATHOLOGY

Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

(2011) Sandra Geschka et al.   PLoS One

Treatment of pulmonary arterial hypertension: The role of prostacyclin and prostaglandin analogs

(2011) Zeenat Safdar   RESPIRATORY MEDICINE

EP4 receptor as a new target for bronchodilator therapy

(2011) J. Buckley et al.   THORAX

Smooth Muscle Proliferation and Role of the Prostacyclin (IP) Receptor in Idiopathic Pulmonary Arterial Hypertension

(2010) Emilia Falcetti et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart

(2010) E. E. Creemers et al.   CARDIOVASCULAR RESEARCH

Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models

(2010) Yuliya Sharkovska et al.   JOURNAL OF HYPERTENSION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension

(2009) Kamal K. Mubarak   RESPIRATORY MEDICINE

Role of the Prostanoid EP4 Receptor in Iloprost-mediated Vasodilatation in Pulmonary Hypertension

(2008) Ying-Ju Lai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pharmacological activation of the prostaglandin E2 receptor EP4 improves cardiac function after myocardial ischaemia/reperfusion injury

(2008) Keiichi Hishikari et al.   CARDIOVASCULAR RESEARCH