Site-Mutation of Hydrophobic Core Residues Synchronically Poise Super Interleukin 2 for Signaling: Identifying Distant Structural Effects through Affordable Computations

Identifying Residues that Determine SCF Molecular-Level Interactions through a Combination of Experimental and In silico Analyses

(2017) Eitan Rabinovich et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

(2017) Yan Li et al.   Nature Communications

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

The rise of IL-2 therapy — a novel biologic treatment for SLE

(2016) Jens Y. Humrich et al.   Nature Reviews Rheumatology

Protein Engineering by Combined Computational and In Vitro Evolution Approaches

(2016) Lior Rosenfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Biophysical and computational methods to analyze amino acid interaction networks in proteins

(2016) Kathleen F. O'Rourke et al.   Computational and Structural Biotechnology Journal

Rational coupled dynamics network manipulation rescues disease-relevant mutant cystic fibrosis transmembrane conductance regulator

(2015) Elizabeth A. Proctor et al.   Chemical Science

Alteration of the C-Terminal Ligand Specificity of the Erbin PDZ Domain by Allosteric Mutational Effects

(2014) Javier Murciano-Calles et al.   JOURNAL OF MOLECULAR BIOLOGY

Amino Acid Networks in a (β/α)8 Barrel Enzyme Change during Catalytic Turnover

(2014) Jennifer M. Axe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

The role of distant mutations and allosteric regulation on LovD active site dynamics

(2014) Gonzalo Jiménez-Osés et al.   Nature Chemical Biology

Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes

(2013) Romain A. Studer et al.   BIOCHEMICAL JOURNAL

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Solution NMR and Computational Methods for Understanding Protein Allostery

(2013) Gregory Manley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

RECENT ADVANCES IN RATIONAL APPROACHES FOR ENZYME ENGINEERING

(2012) Kerstin Steiner et al.   Computational and Structural Biotechnology Journal

ProDy: Protein Dynamics Inferred from Theory and Experiments

(2011) A. Bakan et al.   BIOINFORMATICS

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction Energy Based Protein Structure Networks

(2010) M.S. Vijayabaskar et al.   BIOPHYSICAL JOURNAL

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Visualizing lowly-populated regions of the free energy landscape of macromolecular complexes by paramagnetic relaxation enhancement

(2008) G. Marius Clore   Molecular BioSystems

Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease

(2008) Chun Tang et al.   NATURE

Reassessing a sparse energetic network within a single protein domain

(2008) C. N. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology