Editorial Material
Medicine, General & Internal
Oladapo O. Yeku, Dan L. Longo
Summary: This editorial discusses the scientific basis of a clinical trial conducted by Prager and colleagues, which tested the efficacy of trifluridine-tipiracil and bevacizumab in treating patients with refractory metastatic colorectal cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Gerald W. Prager, Julien Taieb, Marwan Fakih, Fortunato Ciardiello, Eric Van Cutsem, Elena Elez, Felipe M. Cruz, Lucjan Wyrwicz, Daniil Stroyakovskiy, Zsuzsanna Papai, Pierre-Guillaume Poureau, Gabor Liposits, Chiara Cremolini, Igor Bondarenko, Dominik P. Modest, Karim A. Benhadji, Nadia Amellal, Catherine Leger, Loick Vidot, Josep Tabernero
Summary: In this study, researchers found that treatment with trifluridine-tipiracil plus bevacizumab could prolong overall survival in patients with metastatic colorectal cancer compared to trifluridine-tipiracil alone.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Zaoqu Liu, Long Liu, Siyuan Weng, Chunguang Guo, Qin Dang, Hui Xu, Libo Wang, Taoyuan Lu, Yuyuan Zhang, Zhenqiang Sun, Xinwei Han
Summary: The study developed a machine learning-based method to predict prognosis, recurrence, and treatment benefits in colorectal cancer patients, and constructed an immune-related long non-coding RNA signature.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Colorectal cancer is one of the most common and lethal malignant tumors in the world. MicroRNAs have been identified as key regulators in CRC and potential targets to overcome drug resistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Ning Zhang, Xianyu Hu, Yinan Du, Juan Du
Summary: Colorectal cancer is the third most common and fourth most deadly cancer worldwide, with microRNAs playing essential roles in CRC and serving as potential targets for therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tahani Bakhsh, Safiah Alhazmi, Najla Ali Alburae, Ali Farsi, Faisal Alzahrani, Hani Choudhry, Ahmed Bahieldin
Summary: Colorectal cancer is a common type of cancer worldwide, and early diagnosis is crucial for effective treatment. Current blood biomarkers for CRC diagnosis are not accurate enough. Studies have found that specific miRNAs in extracellular vesicles can be used as noninvasive biomarkers for the screening and diagnosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Satoru Nihei, Tatsuki Ikeda, Tomohiko Aoki, Futa Murasato, Mizunori Yaegashi, Koichi Asahi, Kenzo Kudo
Summary: This study analyzed plasma endothelin-1 (ET-1) levels as an indicator of renal endothelial dysfunction in colorectal cancer patients, and found that higher plasma ET-1 levels before treatment might increase the risk of proteinuria in patients treated with bevacizumab.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Oncology
Marinde J. G. Bond, Babette I. Kuiper, Karen Bolhuis, Aysun Komurcu, Martinus J. van Amerongen, Thiery Chapelle, Cornelis H. C. Dejong, Marc R. W. Engelbrecht, Michael F. Gerhards, Dirk J. Grunhagen, Thomas van Gulik, John J. Hermans, Koert P. de Jong, Joost M. Klaase, Niels F. M. Kok, Wouter K. G. Leclercq, Mike S. L. Liem, Krijn P. van Lienden, I. Quintus Molenaar, Ulf P. Neumann, Gijs A. Patijn, Arjen M. Rijken, Theo M. Ruers, Cornelis Verhoef, Johannes H. W. de Wilt, Geert Kazemier, Anne M. May, Cornelis J. A. Punt, Rutger-Jan Swijnenburg
Summary: This study evaluated the variability in assessing resectability and local treatment planning for patients with initially unresectable colorectal cancer liver metastases. The results showed differences and disagreements in the evaluations, highlighting the need for consensus guidelines to prevent unwarranted variability in clinical practice.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Cecile Torregrosa, Simon Pernot, Pauline Vaflard, Audrey Perret, Christophe Tournigand, Violaine Randrian, Solene Doat, Cindy Neuzillet, Valerie Moulin, Morgane Stouvenot, Gael Roth, Tiffany Darbas, Benjamin Auberger, Tiphaine Godet, Marion Jaffrelot, Aurelien Lambert, Olivier Dubreuil, Cassandre Gluszak, Alice Bernard-Tessier, Anthony Turpin, Lola-Jade Palmieri, Olivier Bouche, Gael Goujon, Thierry Lecomte, David Sefrioui, Christophe Locher, Lucien Grados, Pauline Gignoux, Stephanie Trager, Elise Nassif, Angelique Saint, Pascal Hammel, Cedric Lecaille, Mathilde Bureau, Marine Perrier, Damien Botsen, Vincent Bourgeois, Julien Taieb, Edouard Auclin
Summary: In second-line treatment, for patients with metastatic colorectal cancer, the combination of FOLFIRI and bevacizumab is associated with longer overall survival and progression-free survival compared to the combination of FOLFIRI and aflibercept.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Immunology
Yaping Chen, Xiao Zheng, Changping Wu
Summary: Colorectal cancer has the second highest mortality rate globally, and various treatments have improved patient survival. The emergence of ICIs as a new immunotherapy option for advanced CRC is promising, highlighting the importance of understanding the relationship between tumor immune microenvironment and immunotherapy efficacy for selecting appropriate treatment strategies. This review outlines the latest research progress in the immune microenvironment and immunotherapy strategies for CRC.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Calin Cainap, Ovidiu-Vasile Bochis, Catalin Vlad, Raluca Popita, Patriciu Achimas-Cadariu, Andrei Havasi, Andreea Vidrean, Alexandra Dranca, Andra Piciu, Anne-Marie Constantin, Tiberiu Tat, Maniu Dana, Ovidiu Crisan, Cosmin Vasile Cioban, Ovidiu Balacescu, Ovidiu Coza, Loredana Balacescu, Monica Mihaela Marta, Madalina Bota, Simona Cainap
Summary: This study examined the use of bevacizumab beyond disease progression in mCRC patients, showing that doubling the dose of bevacizumab may improve survival. Factors such as dose intensity, primary tumor location, and cumulative exposure to bevacizumab beyond progression were found to significantly influence patient survival.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Qun Xu, Jinyou Li, Yue Wu, Wenjing Zhou, Zherong Xu
Summary: This study investigated the relationship and mechanism between bevacizumab and muscle atrophy through RNA sequencing and bioinformatics analysis. The findings suggest that bevacizumab may lead to muscle mass loss and timp4 and CDKN1A genes are potentially associated with muscle atrophy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhonglin Zhu, Tianan Guo, Junyong Weng, Shanbao Li, Congcong Zhu, Qiuyan Zhao, Ye Xu
Summary: A study investigated the relationship between miRNAs and cuproptosis in colorectal cancer (CRC). Six cuproptosis-related miRNAs were identified and found to be associated with patient survival and immunotherapy sensitivity. Specifically, miR-653 was highly expressed in CRC tissues and promoted cell proliferation and inhibited apoptosis by negatively regulating the expression of DLD.
Review
Biochemistry & Molecular Biology
Monika Prendecka-Wrobel, Dominika Pigon-Zajac, Daria Sondej, Karolina Grzywna, Katarzyna Kaminska, Mariusz Szuta, Teresa Malecka-Massalska
Summary: Colorectal cancer is linked to diet, and researchers are investigating the impact of nutrients on its prevention and treatment. They are studying the role of certain dietary components, such as saturated animal fats, and substances like polyunsaturated fatty acids, curcumin, and resveratrol in colorectal cancer development. Understanding the mechanisms by which food affects cancer cells, particularly the role of microRNAs, is crucial in this research area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chiara Cremolini, Carlotta Antoniotti, Daniele Rossini, Sara Lonardi, Fotios Loupakis, Filippo Pietrantonio, Roberto Bordonaro, Tiziana Pia Latiano, Emiliano Tamburini, Daniele Santini, Alessandro Passardi, Federica Marmorino, Roberta Grande, Giuseppe Aprile, Alberto Zaniboni, Sabina Murgioni, Cristina Granetto, Angela Buonadonna, Roberto Moretto, Salvatore Corallo, Stefano Cordio, Lorenzo Antonuzzo, Gianluca Tomasello, Gianluca Masi, Monica Ronzoni, Samantha Di Donato, Chiara Carlomagno, Matteo Clavarezza, Giuliana Ritorto, Andrea Mambrini, Mario Roselli, Samanta Cupini, Serafina Mammoliti, Elisabetta Fenocchio, Enrichetta Corgna, Vittorina Zagonel, Gabriella Fontanini, Clara Ugolini, Luca Boni, Alfredo Falcone
Article
Medicine, General & Internal
Samanta Salvi, Erika Bandini, Silvia Carloni, Valentina Casadio, Michela Battistelli, Sara Salucci, Ilaria Erani, Emanuela Scarpi, Roberta Gunelli, Giacomo Cicchetti, Michele Guescini, Massimiliano Bonafe, Francesco Fabbri
Summary: Prostate Cancer (PCa) is a common urological cancer which leads to overdiagnosis due to lack of specific diagnostic methods. This study explores the use of extracellular vesicles (EVs) as potential markers for liquid biopsy, showing promising results in detecting physiological and pathological processes related to cancer. The research aims to develop a new workflow for investigating EVs from various biological sources, with significant alterations in EVs potentially related to PCa and BPH.
Editorial Material
Biochemistry & Molecular Biology
Alessandro Passardi, Emanuela Scarpi, Paola Ulivi
Summary: This editorial summarizes six scientific papers on molecular and translational research on colorectal cancer, contributing to the current understanding of potential biomarkers and treatment targets. It aims to identify new strategies to improve diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Elena Lastraioli, Scott P. Fraser, R. Mine Guzel, Jessica Iorio, Lapo Bencini, Emanuela Scarpi, Luca Messerini, Vincenzo Villanacci, Giulia Cerino, Niccolo' Ghezzi, Giuseppe Perrone, Mustafa B. A. Djamgoz, Annarosa Arcangeli
Summary: The voltage-gated sodium channel subtype nNav1.5 is highly expressed in colorectal cancer tissues compared to normal tissues, and its expression level is inversely correlated with disease-free survival. nNav1.5 also co-occurs with other biomarkers associated with metastasis in colorectal cancer, suggesting its potential as a novel clinical biomarker and a target for anti-metastatic therapies.
Article
Biochemistry & Molecular Biology
Alessandro Passardi, Ilario Giovanni Rapposelli, Emanuela Scarpi, Francesco Giulio Sullo, Giulia Bartolini, Elisa Neri, Giulia Ghigi, Luca Tontini, Giorgio Ercolani, Manlio Monti, Silvia Ruscelli, Laura Matteucci, Martina Valgiusti, Giovanni Luca Frassineti, Antonino Romeo
Summary: The combination of chemotherapy and radiotherapy is a widely used treatment option for locally advanced pancreatic cancer (LAPC). The study found that ECOG performance status and CA 19-9 levels were associated with improved overall survival and progression-free survival, with low CA19-9 levels predicting resectability. Further research is needed to better understand tumor biology in LAPC for improved prediction of resectability and prognosis.
Article
Oncology
Vincenza Conteduca, Chiara Casadei, Emanuela Scarpi, Nicole Brighi, Giuseppe Schepisi, Cristian Lolli, Giorgia Gurioli, Ilaria Toma, Giulia Poti, Alberto Farolfi, Ugo De Giorgi
Summary: This study investigates the correlation between PSA response endpoints, plasma DNA analysis and progression free/overall survival in prostate cancer, highlighting the importance of a multimodal approach in predicting outcomes.
Article
Oncology
Emanuela Scarpi, Oriana Nanni, Marco Maltoni
Summary: Accurate prediction of survival is crucial in a palliative care setting. The Palliative Prognostic (PaP) score has been developed to assign patients to different risk groups based on 30-day survival probability. This study focused on developing and validating a PaP nomogram for individualized prediction of survival at 15, 30, and 60 days. The nomogram showed good performance and calibration, making it a valuable tool for end-of-life care decision-making.
Article
Immunology
Elena Pancisi, Anna Maria Granato, Emanuela Scarpi, Laura Ridolfi, Silvia Carloni, Cinzia Moretti, Massimo Guidoboni, Francesco De Rosa, Sara Pignatta, Claudia Piccinini, Valentina Soldati, Luana Calabro, Massimo Framarini, Monica Stefanelli, Jenny Bulgarelli, Marcella Tazzari, Francesca Fanini, Massimiliano Petrini
Summary: Advanced therapy medical products (ATMPs) are an important and rapidly growing field in innovative medicine. In this study, a stability program was developed to evaluate the quality parameters and establish the shelf life of frozen dendritic cell (DC) vaccines. The data collected demonstrate that freezing and thawing do not disturb the functional and quality characteristics of the DC vaccine product over time.
Article
Biochemistry & Molecular Biology
Jessica Iorio, Lorenzo Antonuzzo, Emanuela Scarpi, Massimo D'Amico, Claudia Duranti, Luca Messerini, Clotilde Sparano, Damiano Caputo, Daniele Lavacchi, Domenico Borzomati, Alice Antonelli, Lorenzo Nibid, Giuseppe Perrone, Alessandro Coppola, Roberto Coppola, Francesco di Costanzo, Elena Lastraioli, Annarosa Arcangeli
Summary: hERG1 protein is expressed in human neuroendocrine tumors originating from the ileum or pancreas, and it has prognostic value in these cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Giulia Lorenzoni, Elisabetta Petracci, Emanuela Scarpi, Ileana Baldi, Dario Gregori, Oriana Nanni
Summary: Sequential multiple assignments randomized trials (SMARTs) are an experimental design in which patients are randomized multiple times according to pre-specified decision rules. This study investigates the current state of SMART designs in oncology and identifies a discrepancy between the statistical literature and actual procedures used in cancer clinical trials. A systematic review found that SMART designs in oncology are still limited and there is a need for formal reporting guidelines.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Valentina Zampiga, Ilaria Cangini, Erika Bandini, Irene Azzali, Mila Ravegnani, Alessandra Ravaioli, Silvia Mancini, Michela Tebaldi, Gianluca Tedaldi, Francesca Pirini, Luigi Veneroni, Giovanni Luca Frassineti, Fabio Falcini, Rita Danesi, Daniele Calistri, Valentina Arcangeli
Summary: PVs and LPVs in BRCA1/2 genes are associated with a high risk of breast and/or ovarian cancer, and more BRCA1/2 variants have recently been found to be linked to pancreatic cancer. Inherited factors, particularly deleterious variants of BRCA2, play a role in 10% to 20% of pancreatic cancers. The frequency of BRCA1/2 germline alterations varies among ethnic groups, and the accurate estimation of PVs/LPVs variants in Italian HBOC families is still uncertain. This study aims to determine the prevalence of a BRCA2 PV in a specific cohort of HBOC patients and their relatives from the eastern coast of Emilia Romagna, Italy, and provides important evidence for genetic counseling and surveillance programs due to the increased risk of pancreatic and breast cancer.
Article
Biochemistry & Molecular Biology
Maria Concetta Cursano, Emilio Francesco Giunta, Emanuela Scarpi, Chiara Casadei, Alessandra Virga, Paola Ulivi, Sara Bleve, Nicole Brighi, Giorgia Ravaglia, Francesco Pantano, Vincenza Conteduca, Daniele Santini, Ugo De Giorgi
Summary: This study evaluated the prevalence of DNA damage repair (DDR) gene mutations in castration-resistant prostate cancer (CRPC) patients and their impact on clinical outcomes related to bone metastases. The results showed that DDR mutations were associated with larger bone metastases volume, but did not affect skeletal-related events incidence and time to onset.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Manlio Monti, Andrea Prochowski Iamurri, David Bianchini, Chiara Gallio, Luca Esposito, Daniela Montanari, Silvia Ruscelli, Chiara Molinari, Flavia Foca, Alessandro Passardi, Giovanni Vittimberga, Paolo Morgagni, Giovanni Luca Frassineti
Summary: This study aimed to investigate the association between routine blood parameters, inflammatory response markers, sarcopenia, adipose tissue depletion, and compliance to neoadjuvant/perioperative chemotherapy for gastric cancer. The results showed that changes in platelet to lymphocyte ratio (PLR) were associated with treatment interruption, while fat loss and sarcopenia were not related to compliance.
Article
Oncology
Chiara Molinari, Gianluca Tedaldi, Francesca Rebuzzi, Paolo Morgagni, Laura Capelli, Sara Ravaioli, Maria Maddalena Tumedei, Emanuela Scarpi, Anna Tomezzoli, Riccardo Bernasconi, Maria Raffaella Ambrosio, Alessia D'Ignazio, Leonardo Solaini, Francesco Limarzi, Giorgio Ercolani, Giovanni Martinelli, Paola Ulivi, Luca Saragoni
Summary: The study characterized differences between Pen A, Pen B, and T3N0 gastric cancers, identifying MUC6 overexpression in Pen A and GATA6 amplification in Pen B as notable biomarkers. Co-occurrence of TP53 mutation and loss of heterozygosity was mainly seen in Pen A tumors.
Article
Oncology
Andrea Casadei Gardini, Emanuela Scarpi, Martina Valgiusti, Manlio Monti, Silvia Ruscelli, Laura Matteucci, Giulia Bartolini, Bernadette Vertogen, Flavia Pagan, Giulia Rovesti, Giovanni Luca Frassineti, Alessandro Passardi
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)