Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Cui Wang, Xiaoyi Wang, Yinyin Xie, Tingting Peng, Yongfeng Wang, Nan Li, Xiangbo Huang, Xiaomei Hu, Nanchang Xie
Summary: This study demonstrated that ATF5 can attenuate low-magnesium-induced endoplasmic reticulum stress (ERS) by preventing the accumulation of mitochondrial reactive oxygen species (ROS), thereby rescuing neuronal cells from apoptosis.
Article
Biochemistry & Molecular Biology
Fawzi Khoder-Agha, Thomas Kietzmann
Summary: Reactive oxygen species (ROS) and glycans play crucial roles in cells, both dynamically responding to stressors to maintain cellular balance. The delicate balance of redox potential and glycan biosynthesis vitality are essential for cell survival.
Article
Genetics & Heredity
Junting Weng, Danjuan Liu, Bingbing Shi, Min Chen, Shuoyun Weng, Rongjie Guo, Xiaoping Zhou
Summary: This study investigated the therapeutic effects of the neutrophil elastase inhibitor Sivelestat sodium (SIV) in treating lipopolysaccharide (LPS)-induced acute lung injury (ALI) by improving endoplasmic reticulum stress (ERS). The results showed that SIV could improve ALI and suppress the LPS-induced ERS response.
Article
Biochemistry & Molecular Biology
Danyang Li, Ruqin Lin, Yangyang Xu, Qingmei Chen, Fengru Deng, Yiqun Deng, Jikai Wen
Summary: Long-term exposure to Cereulide causes oxidative stress in liver and kidney tissues, leading to activation of ER stress pathways and ultimately apoptosis and tissue damage. Inhibition of these pathways can reduce the toxic effects of this toxin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jiajian Cao, Chunhua Wang, Ning Hao, Toru Fujiwara, Tao Wu
Summary: In this review, we summarize the perceptions and responses of ER stress and oxidative protein folding in plants and analyze the production and signaling of ROS under ER stress in detail. This provides a theoretical basis for reducing ER stress and improving crop survival rate.
Article
Biochemistry & Molecular Biology
Li Yang, Xing Wang, Yongfei Zhao, Ke Xue, Jiankang Liang, Xiaohan Wang, Jing Deng, Zhengjian Qi
Summary: In this study, an AIE-type strong endoplasmic reticulum-targeted luminogen (MTOQS) was developed. MTOQS efficiently produced reactive oxygen species (ROS) in cellular and non-cellular environments, effectively reducing levels of GSH and MDA in cancer cells. Through dual organelle oxidative stress, MTOQS altered cancer cell metabolism and culture environment, leading to apoptosis by damaging endoplasmic reticulum and mitochondria.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Xing-Yang Xiang, Ting Liu, Yue Wu, Xu-Shun Jiang, Jun-Ling He, Xue-Mei Chen, Xiao-Gang Du
Summary: The study found that BBR can reduce PA-induced podocyte apoptosis, while 4-phenylbutyric acid significantly decreased PA-induced cell apoptosis and expression of ER stress-related proteins, indicating that ER stress is involved in PA-induced podocyte apoptosis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Yung Hyun Choi, Hyesook Lee, Chang-Hee Kang, Mi-Hwa Lee, Chang-Min Lee, Gi-Young Kim
Summary: The study showed that fisetin can effectively prevent PM2.5-induced apoptosis by inhibiting the ER stress response and production of reactive oxygen species (ROS).
Article
Biochemistry & Molecular Biology
Yuxin Huang, Xiyuan Ping, Yilei Cui, Hao Yang, Jing Bao, Qichuan Yin, Hailaiti Ailifeire, Xingchao Shentu
Summary: This study investigates how lens epithelial cells adapt and maintain normal growth and metabolic activity under hypoxic conditions. The findings show that the glycolysis pathway is upregulated, enabling the cells to maintain energy metabolism and resist cell apoptosis caused by ER stress and ROS production. The study also provides insights into possible cellular damage repair mechanisms.
Review
Biochemistry & Molecular Biology
Yang Liu, Shujun Zhou, Du Xiang, Lingao Ju, Dexin Shen, Xinghuan Wang, Yanfeng Wang
Summary: Acute lung injury (ALI) is a condition caused by various factors leading to acute hypoxic respiratory insufficiency, with oxidative stress playing a significant role in its pathogenesis. While antioxidants can alleviate ALI by scavenging ROS, they may have no significant effect and could even aggravate severe organ injury.
Article
Anatomy & Morphology
Ming Yan, Yun Zhang, Wanting Niu, Kezhou Liu, Lingyun Xue, Kexin Zhou
Summary: During orthodontic tooth movement, the most mechanosensitive cells in alveolar bone, osteocytes, suffer from compressive force and lead to alveolar bone resorption on the compression side. The mechanisms of compressive force-induced osteocyte death remain unclear. This study establishes an OTM model and examines the involvement of reactive oxygen species (ROS)-mediated endoplasmic reticulum stress (ERS) pathway in compressive force-induced osteocyte death.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Oncology
Yue Li, Chen Chen, Hai-Lin Liu, Chen-Guang Li, Zhen-Fa Zhang, Chang-Li Wang
Summary: The study demonstrates that pazopanib induces apoptosis of SCLC cells through the upregulation of ROS levels via the ER-stress pathway. Further research on relevant biomarkers for accurately selecting patients who will benefit from pazopanib should be carried out.
Article
Immunology
Wenyang Jiang, Jie Ren, Hongling Zhou, Ruyuan He, Donghang Li, Rui Xiong, Zhuokun He, Dan Cheng
Summary: This study found that TMEM16A plays an important role in sepsis-induced acute lung injury (ALI) by regulating endoplasmic reticulum stress-induced ferroptosis in alveolar epithelial type II (AT2) cells. Knockout of TMEM16A improved lung function and alleviated lung pathological injury in LPS-treated mice. Inhibition of TMEM16A by shikonin also showed therapeutic effect on LPS-induced ALI in vivo.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)