Article
Oncology
Cornelia Liedtke, Chafika Mazouni, Kenneth R. Hess, Fabrice Andre, Attila Tordai, Jaime A. Mejia, W. Fraser Symmans, Ana M. Gonzalez-Angulo, Bryan Hennessy, Marjorie Green, Massimo Cristofanilli, Gabriel N. Hortobagyi, Lajos Pusztai
Summary: This study compared the response to neoadjuvant chemotherapy and survival between patients with triple-negative breast cancer (TNBC) and non-TNBC. The results showed that TNBC patients had higher pathologic complete response rates but lower 3-year progression-free survival rates and 3-year overall survival rates. TNBC was associated with increased risk for visceral metastases, lower risk for bone recurrence, and shorter postrecurrence survival. Patients with TNBC had worse survival if they had residual disease after neoadjuvant chemotherapy.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Environmental Sciences
Xuan Li, Tao Yu, Muxin Zhai, Yongyuan Wu, Baojing Zhao, Cancan Duan, Huiru Cheng, Han Li, Zhaolian Wei, Yuanyuan Yang, Zhen Yu
Summary: This study found that cadmium exposure reduces placental angiogenesis in preeclampsia by decreasing the expression of PLGF and VEGF and increasing the expression of sFlt1. Cadmium exposure also decreases the expression of thyroid hormone receptor alpha and Dio2. These results suggest that cadmium exposure impairs placental angiogenesis in preeclampsia by disturbing thyroid hormone receptor signaling.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Article
Pharmacology & Pharmacy
Xiaojie Zhang, Kai Chen, Zhu Meng, Ru Jia, Feifei Lian, Feng Lin
Summary: In this study, we found that exposure to cadmium in pregnant rats can lead to the development of preeclampsia-like symptoms, including hypertension, albuminuria, and fetal growth restriction. Furthermore, cadmium exposure also inhibits the synthesis of progesterone in the placenta, which contributes to the onset of preeclampsia in pregnant rats.
Review
Biology
Amani A. Mahbub
Summary: Several epidemiological studies have suggested that the use of female sex steroid hormones can reduce the risk of colon cancer. This review summarizes the available data on the effects of estradiol and progesterone treatments in male and female in vitro and in vivo models of colon cancer, along with their potential molecular mechanisms. The studies showed that estradiol treatment and activation of its beta receptor inhibited cell proliferation, induced cell cycle arrest, and promoted apoptosis through molecular pathway modulation. Similarly, the inhibition of the alpha receptor also had antitumorigenic effects. Limited studies on progesterone revealed promising tumoricidal actions. Furthermore, the combination of estradiol and progesterone showed enhanced anticancer activities compared to monotherapy. Overall, these studies suggest that female sex steroid hormones could be a novel and effective therapeutic strategy against colon cancer.
Article
Biology
Alejandro La Greca, Nicolas Bellora, Francois Le Dily, Rodrigo Jara, Ana Silvina Nacht, Javier Quilez Oliete, Jose Luis Villanueva, Enrique Vidal, Gabriela Merino, Cristobal Fresno, Inti Tarifa Reischle, Griselda Vallejo, Guillermo Vicent, Elmer Fernandez, Miguel Beato, Patricia Saragueta
Summary: Estrogen and progesterone play important roles in the development and transcriptional regulation of endometrial cancer. PAX2 is involved in fine-tuning the interplay between ERalpha and PR in transcriptional regulation, and the open chromatin state of specific regions is associated with regulated genes.
Article
Obstetrics & Gynecology
Sevtap Han, Ali Fuat Cicek, Aytekin Tokmak, Tugce Yildirir Ustun, Nilufer Ercan Gokay, Mecit Orhan Uludag, Murside Ayse Demirel
Summary: Resveratrol treatment can lower serum estradiol levels, increase progesterone levels, and enhance receptor expression in rats with endometritis. When combined with marbofloxacin, it can further increase receptor expression.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Antonio Martinez-Ortega, Alvaro Flores-Martinez, Eva Venegas-Moreno, Elena Dios, Diego Del Can, Eloy Rivas, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, Elena Fajardo, Florinda Roldan, Natividad Gonzalez-Rivera, Rosario Oliva, Jose Ignacio Fernandez-Pena, Alfonso Soto-Moreno, David A. Cano
Summary: This study systematically analyzed the expression of estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in craniopharyngiomas (CPs) and explored their potential association with tumor aggressiveness features. The results showed that a substantial proportion of CPs displayed PR expression, but most CPs expressed low levels of ER alpha. No major association between PR and ER alpha expression and clinical aggressiveness features was observed in CPs. Additionally, beta-catenin accumulation was not related to tumor recurrence in this series.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Michal Kunc, Marta Popeda, Wojciech Biernat, Elzbieta Senkus
Summary: ER alpha(+)/PgR(-) phenotype is not rare in breast cancer, and loss of PgR expression may signify resistance to endocrine therapy and poorer outcomes. Different mechanisms of PgR loss have distinct consequences on cancer cell biology.
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Review
Oncology
Andrea Ronchi, Francesca Pagliuca, Federica Zito Marino, Marina Accardo, Immacolata Cozzolino, Renato Franco
Summary: Biomarkers on cancer tissue samples can be identified through technologies like immunohistochemistry and in situ hybridization, especially in breast cancer pathology for diagnostic, prognostic, and therapeutic response purposes. Pathologists play an increasingly important role in defining prognosis and choosing therapy based on immunohistochemical biomarkers, guiding treatment and classifying breast cancer into distinct subtypes.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Hengqiang Zhao, Yiping Gong
Summary: Single estrogen receptor (ER)+ and progesterone receptor (PR)+ tumors account for about 10% of all breast cancers. The prognosis of these tumors varies based on HER2 status, with single ER+ and PR+ patients showing different survival outcomes in different HER2 subtypes. In HER2- subtype, single PR+ patients had poorer prognoses than single ER+ patients, while in HER2+ subtype, single ER+ and PR+ patients showed similar prognoses compared with ER-PR- patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
H. Mirzaei-Alamouti, R. Hadionnejad, A. Abdollahi, A. Bahari, F. Fatahnia, R. Masoumi, M. P. Green, M. Vazirigohar, M. Mansouryar
Summary: This study investigated the effects of varying the plane of nutrition on gene expression related to mammary gland development in a seasonal sheep breed. The findings showed a positive impact of high-nutrient diet on mammary gland development, and revealed a complex relationship between the expression of genes critical for mammary gland function and development. These findings provide valuable insights for future nutritional strategies to optimize animal liveweight gain and mammary gland development.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Oncology
Danian Dai, Hongmei Wu, Hongkai Zhuang, Rong Chen, Cheng Long, Bo Chen
Summary: This study investigated the clinical and genetic characteristics of ER + / PR- breast cancer patients in China. Different PR statuses indicated diverse biological processes of ER + breast cancer and survival outcomes. Tailored treatment strategies may be needed for ER + / PR- patients.
Article
Medicine, Research & Experimental
Eun-Jin Kang, Jae-Eon Lee, Sung-Min An, Jae Ho Lee, Hyeog Soong Kwon, Byoung Chul Kim, Seon Jong Kim, Joo Man Kim, Dae Youn Hwang, Young-Jin Jung, Seung Yun Yang, Seung Chul Kim, Beum-Soo An
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2015)
Article
Oncology
Sung-Min An, Sun Suk Kim, Jun Kim, Mee-Na Park, Jae-Eon Lee, Seong Keun Cho, Kyu-Sup Lee, Beum-Soo An
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Ye Young Shin, Jea Sic Jeong, Mee-Na Park, Jae-Eon Lee, Sung-Min An, Wan-Seob Cho, Seung Chul Kim, Beum-Soo An, Kyu-Sup Lee
MOLECULAR MEDICINE REPORTS
(2018)
Article
Engineering, Biomedical
Sung-Min An, Keum-Yong Seong, Sang-Gu Yim, Young Jun Hwang, Seong Hwan Bae, Seung Yun Yang, Beum-Soo An
ACTA BIOMATERIALIA
(2018)
Article
Obstetrics & Gynecology
Jea Sic Jeong, Dong Hyung Lee, Jae-Eon Lee, Sung-Min An, Pyong In Yi, Geun-Shik Lee, Dae Youn Hwang, Seung Yun Yang, Seung Chul Kim, Beum-Soo An
REPRODUCTIVE SCIENCES
(2020)
Article
Biophysics
Ye-Eun Kang, Keum-Yong Seong, Sang-Gu Yim, Yechan Lee, Sung-Min An, Seung Chul Kim, Kyujung Kim, Beum-Soo An, Kyu-Sup Lee, Seung Yun Yang
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Oncology
Ye Young Shin, Sung-Min An, Jea Sic Jeong, Seung Yun Yang, Geun-Shik Lee, Eui-Ju Hong, Eui-Bae Jeung, Seung Chul Kim, Beum-Soo An
Summary: The induction of pre-eclampsia conditions dysregulates steroid hormones through the regulation of steroidogenic enzymes, depending on specific pre-eclampsia symptoms.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Chemistry, Analytical
Jaewon Jung, Sung-Min An, Eun-Kyung Lim, Seung-Chul Kim, Beum-Soo An, Sungbaek Seo
Summary: A sensing platform based on PDA was developed to detect testosterone as a potential biomarker of preterm birth. By conjugating anti-T antibodies to PDA assemblies and using a mixture of acetonitrile and distilled water as a solvent, the platform showed over 3.4 times higher sensitivity for detecting T compared to other sex steroid hormones studied.
Article
Reproductive Biology
So Young Kim, Young Joo Lee, Sung-Min An, Min Jae Kim, Jea Sic Jeong, Da Som Kim, Yong Lim, Eui-Man Jung, Seung-Chul Kim, Beum-Soo An
Summary: The purpose of this study was to investigate lipid metabolism in the placenta of gestational diabetes mellitus individuals and its impact on the fetus. The study found that lipogenesis was stimulated in high blood glucose conditions, while lipolysis was activated as gestational diabetes mellitus progressed. This imbalance in lipid metabolism may cause metabolic complications in the fetus.
BIOLOGY OF REPRODUCTION
(2022)
Article
Energy & Fuels
Nam Seon Kang, Kichul Cho, Sung Min An, Eun Song Kim, Hyunji Ki, Chung Hyeon Lee, Grace Choi, Ji Won Hong
Summary: This study investigated the morphological, molecular, and biochemical characteristics of Graesiella emersonii from the Geumgang Estuary in Korea. It found that this species is a commercially exploitable source of bioactive compounds and biofuels with potential applications in microalgae-based industries. The study also identified the optimal growth conditions for G. emersonii and determined its fatty acid composition and value-added carotenoids production.
Article
Plant Sciences
Sung Min An, Jihoon Kim, Nam Seon Kang, Kichul Cho, Jung A. Lee, Eun Song Kim
Summary: A new species of benthic diatoms, Halamphora minima, was discovered from a tidal mudflat. It is the smallest species of the genus Halamphora known to date. This study provides a detailed description of the characteristics and phylogenetic analysis of H. minima.
Article
Andrology
Sung-Min An, Min Jae Kim, Jea Sic Jeong, So Young Kim, Da Som Kim, Beum-Soo An, Seung Chul Kim
Summary: Oxytocin (OXT) plays a crucial role in pregnancy by regulating the differentiation of placental cells and steroid hormone synthesis. Studies have shown that OXT enhances the production of progesterone and dehydroepiandrosterone (DHEA) by increasing the expression of steroidogenic enzymes. Additionally, OXT affects placental cell differentiation, which is closely associated with steroidogenesis.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2023)
Article
Toxicology
Sung-Min An, Min Jae Kim, Keum-Yong Seong, Jea Sic Jeong, Hyeon-Gu Kang, So Young Kim, Da Som Kim, Da Hee Kang, Seung Yun Yang, Beum-Soo An
TOXICOLOGICAL RESEARCH
(2019)
Article
Toxicology
So-Hye Hong, Jae-Eon Lee, Sung-Min An, Ye Young Shin, Dae Youn Hwang, Seung Yun Yang, Seong-Keun Cho, Beum-Soo An
TOXICOLOGICAL RESEARCH
(2017)