Review
Polymer Science
Sara Perez Davila, Laura Gonzalez Rodriguez, Stefano Chiussi, Julia Serra, Pio Gonzalez
Summary: This paper reviews the effects of sterilization techniques on the properties of PLA medical devices, focusing on how conventional sterilization methods impact their physicochemical and biocompatible properties. It also presents emerging and alternative sterilization methods for sensitive biomaterials.
Article
Multidisciplinary Sciences
Francis M. Cavallo, Richard Kommers, Alexander W. Friedrich, Corinna Glasner, Jan Maarten van Dijl
Summary: The microbiological safety of medical devices is crucial for patients and manufacturers. This study explores the use of high oxygen concentrations to disinfect surfaces contaminated with different bacteria. The results demonstrate that some opportunistic pathogens, like Pseudomonas aeruginosa, are highly sensitive to oxygen concentrations higher than atmospheric levels. Additionally, high oxygen concentrations effectively reduce P. aeruginosa contamination in nebulizers used by cystic fibrosis patients. However, complete elimination of microbial contaminants may require combining oxygen-based disinfection with other agents, such as ethanol or hydrogen peroxide.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Saharnaz Bargh, Mine Silindir-Gunay, A. Yekta Ozer, Melike Ekizoglu, Didem Kart, Burak Kutlu, Rahime Nohutcu
Summary: The study found that both gamma radiation and microwave are effective sterilization methods for periodontological grafts, with minimum sterilization doses of 5 kGy and 3 minutes, respectively. Microwave sterilization can be used as an alternative novel method to gamma radiation sterilization, successfully sterilizing various coded periodontological grafts.
Article
Polymer Science
Stana Kovacevic, Beti Rogina-Car, Ana Kis
Summary: This research tested a newly developed 3D fabric as a packaging material for hospital sterilization. The study found that the woven fabric had exceptional puncture strength and formed an effective microbial barrier, making it suitable for use in medical sterilization.
Article
Chemistry, Physical
Mao Kaneko, Masanori Hiratsuka, Ali Alanazi, Hideki Nakamori, Kazushige Namiki, Kenji Hirakuri
Summary: DLC coatings show good performance in intracorporeal medical devices, with strong adhesion and stability, resistance to damage, and maintained anti-reflection properties. Therefore, DLC coatings can help improve the surface quality of medical devices and extend their lifespan.
Review
Engineering, Chemical
Emmanuel I. Epelle, Andrew Macfarlane, Michael Cusack, Anthony Burns, Jude A. Okolie, Parag Vichare, Luc Rolland, Mohammed Yaseen
Summary: The control of infectious diseases can be improved through carefully designed decontamination equipment and systems. Ozone has gained significant research interest as a powerful antimicrobial agent in the past decade. The COVID-19 pandemic has driven the development of new ozone-based technologies for decontamination purposes. It is important to consider key factors that affect the application of lab-based findings to large-scale ozone systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Physics, Applied
Paolo Seri, Silvia Nici, Martina Cappelletti, Silvia G. Scaltriti, Arturo Popoli, Andrea Cristofolini, Gabriele Neretti
Summary: Nowadays, sterilization methods for disposable medical devices have drawbacks in terms of safety, energy consumption, and costs. This study presents a sterilization method using indirect nonthermal plasma treatment, which has advantages in terms of low environmental impact and backward compatibility. The method utilizes reactive species produced by a plasma reactor to achieve sterilization of devices enclosed in protective packaging. Complete sterilization was achieved for various devices using USP and EU-PHARMA protocols, with the need for pretreatment of carton packaging.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Chemistry, Physical
Leonard S. Fifield, Matt Pharr, David Staack, Suresh D. Pillai, Larry Nichols, James McCoy, Tony Faucette, Tucker T. Bisel, Min Huang, Md Kamrul Hasan, Lucas Perkins, Scott K. Cooley, Mark K. Murphy
Summary: Effective sterilization methods for single-use devices are in growing demand in the medical industry. This study compared the effects of e-beam and X-ray radiation with gamma radiation for sterilization of medical devices, finding that both e-beam and X-ray irradiation are viable alternatives.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Health Policy & Services
Tuncay Bayrak, Saliha Isil Soylu
Summary: Reprocessing of single use medical devices has become popular after the new EU Medical Device Regulation in 2017. A new regulation model and tracking system were proposed based on stakeholder opinions, with most respondents agreeing that it can reduce healthcare spending and ensure patient safety.
HEALTH POLICY AND TECHNOLOGY
(2021)
Article
Chemistry, Physical
Leonard S. Fifield, Matt Pharr, David Staack, Suresh D. Pillai, Larry Nichols, James McCoy, Tony Faucette, Tucker T. Bisel, Min Huang, Md Kamrul Hasan, Lucas Perkins, Scott K. Cooley, Mark K. Murphy
Summary: A study compared the effects of gamma, e-beam, and X-ray radiation on medical device polymers, finding that e-beam and X-ray are viable alternatives to gamma irradiation.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Food Science & Technology
Jun-Jie Ma, Zhi-Wei Wang, Jing Xu, Chang-Ying Hu, Tian-Cheng Qiu, Zhan-Yan Huang
Summary: An ultra-high-performance liquid chromatography-tandem mass spectrometry method was used to evaluate the migration levels of primary aromatic amines (PAAs) in 147 laminated food bags on the market. Results showed that 3% of the bags were non-compliant. The main migrating substances were found to be 4,4' -methylenedianiline (4,4' -MDA), 2,4' -methylenedianiline (2,4' -MDA) and 2,2' -methylenedianiline (2,2' -MDA) (MDAs), with 2,2' -MDA being the main contributor to the excess of total migration of PAAs. Autoclaving increased the migration of 4,4' -MDA and 2,4' -MDA to food simulants, while Co-60-gamma irradiation resulted in a significant decrease in the migration of MDAs. The study suggests that irradiation and high-pressure processing are relatively safe methods in terms of PAAs migration.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Food Science & Technology
Jun-Jie Ma, Zhi-Wei Wang, Jing Xu, Chang-Ying Hu, Tian-Cheng Qiu, Zhan-Yan Huang
Summary: The study used an ultra-high-performance liquid chromatography-tandem mass spectrometry method to evaluate the migration levels of primary aromatic amines in 147 laminated food bags, finding 3% of them to be non-compliant. By conducting migration tests and simulated food processing experiments, the effects of autoclaving, irradiation, and high-pressure processing on the migration of substances were investigated, showing that irradiation and HPP are relatively safe sterilization methods in terms of PAAs migration.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Materials Science, Multidisciplinary
Roland Told, Zoltan Ujfalusi, Attila Pentek, Monika Kerenyi, Krisztina Banfai, Andras Vizi, Peter Szabo, Szilvia Melegh, Judit Bovari-Biri, Judit E. Pongracz, Peter Maroti
Summary: This study evaluates the effect of different sterilization and disinfection methods on the most commonly used additive manufacturing technologies and materials in medical device development. The results show significant structural or aesthetic alterations after the sterilization and disinfection treatments, but no significant cytotoxic effect is observed.
MATERIALS & DESIGN
(2022)
Review
Biotechnology & Applied Microbiology
Mehdi Kazemzadeh-Narbat, Hao Cheng, Rosa Chabok, Mario Moises Alvarez, Cesar De La Fuente-Nunez, K. Scott Phillips, Ali Khademhosseini
Summary: This review discusses the use of antimicrobial peptides (AMPs) as an alternative to conventional antibiotics to reduce infections in medical devices, focusing on their broad-spectrum antimicrobial activity and strategies for incorporating them into medical devices materials. The regulatory perspective on AMP coatings, specifically in the US market, aims to bridge the gap between academic studies and preclinical testing to advance the regulatory science of antimicrobial coatings.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Article
Medicine, General & Internal
Samuel J. Lee, Lauren Cho, Eyal Klang, James Wall, Stefano Rensi, Benjamin S. Glicksberg
Summary: This study identified a gap in both quantity and diversity of high-risk devices indicated for the pediatric population through analyzing PMA statements. The scarcity of pediatric devices limits therapeutic possibilities for children, and efforts should be made to address this gap and prioritize clinical specialties in need of pediatric device innovation.
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Vladislav Volarevic, Valentin Djonov, Ana Volarevic
Summary: AT-MSC-Exos are potential therapeutic agents for neural and retinal diseases by delivering neurotrophins, immunoregulatory factors, and pro-angiogenic miRNAs to alleviate inflammation and promote cell survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Carl Randall Harrell, Dragica Pavlovic, Dragana Miloradovic, Milica Dimitrijevic Stojanovic, Valentin Djonov, Vladislav Volarevic
Summary: d-MAPPS enhances antitumor immune response against breast cancer cells and suppresses tumor growth.
ANALYTICAL CELLULAR PATHOLOGY
(2022)
Article
Medicine, General & Internal
Zoran Kovacevic, Tatjana Lazarevic, Nela Maksimovic, Milka Grk, Vladislav Volarevic, Marina Gazdic Jankovic, Svetlana Djukic, Katarina Janicijevic, Marina Miletic Kovacevic, Biljana Ljujic
Summary: Galectin 3 plays a significant role in the development of chronic renal failure. This study found that LGALS3 gene polymorphisms rs4644 and rs4652 are associated with biochemical parameters and diseases in ESRD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: This review article summarizes the therapeutic effects and mechanisms of mesenchymal stem cells (MSC) and their exosomes (MSC-Exos) in the treatment of inflammatory eye diseases and ocular graft-versus-host disease (oGVHD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marija Zdravkovic, Carl Randall Harrell, Vladimir Jakovljevic, Valentin Djonov, Vladislav Volarevic
Summary: Mesenchymal stem cells (MSCs) are adult stem cells that regulate tissue homeostasis through their regenerative, pro-angiogenic and immunomodulatory properties. In obstructive sleep apnea (OSA), MSCs are recruited from their niches in inflamed and injured tissues to reduce hypoxia, suppress inflammation, prevent fibrosis and enhance tissue regeneration. Animal studies have demonstrated the therapeutic efficacy of MSCs in attenuating OSA-induced tissue injury and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Carl Randall Harrell, Lisa Feulner, Valentin Djonov, Dragica Pavlovic, Vladislav Volarevic
Summary: Dry eye disease is a complex eye disorder characterized by a deficiency in tear fluid quantity and/or quality. It involves various underlying pathologies such as loss of homeostasis, tear instability, hyperosmolarity, and detrimental inflammatory responses. Dry eye disease leads to neurosensory dysfunction and visual disturbance, significantly impacting patients' quality of life. Understanding the pathogenic processes of dry eye disease is crucial for developing effective treatment approaches.
Review
Cell Biology
Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic
Summary: Cigarette smoke and nicotine have detrimental effects on the therapeutic potential of MSCs by reducing proliferation, migration, as well as chondrogenic and osteogenic differentiation abilities.
HISTOLOGY AND HISTOPATHOLOGY
(2022)