期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 308, 期 5, 页码 534-538出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2018.05.007
关键词
STEC O80:H2; Extraintestinal; Virulence; Hybrid; Core genome
资金
- Swiss Federal Office of Public Health, Division Communicable Diseases
Shiga toxin-producing E. coil (STEC) O80:H2 is an uncommon hybrid pathotype that has recently emerged in France. We analysed 18 STEC O80:H2 isolated from humans in Switzerland during 2010-2017. All isolates carried stx2a or stx2d, the rare eae variant eae-xi, and at least seven virulence genes associated with pS88, a plasmid that is found in extraintestinal pathogenic E. cob (ExPEC). Whole genome sequencing (WGS) identified additional chromosomal extraintestinal virulence genes encoding for type 1 fimbria (fimA, fimC and fimH), aerobactin (iuc/iutA) and afimbrial adhesins (afaA/C/D/E-VIII). Core genome multi-locus sequence typing (cgMLST) detected two closely related but distinct subclusters with different six2 and iuc/iutA genotypes. All isolates were multidrug resistant (MDR), but susceptible to third generation cephalosporins and azithromycin. STEC/ExPEC hybrid pathotypes such as STEC O80:H2 represent a therapeutical challenge in the event of extraintestinal infection.
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