Review
Biochemistry & Molecular Biology
Alicja M. Kmiecik, Piotr Dziegiel, Marzenna Podhorska-Okolow
Summary: Cancer is heterogeneous, and the protein NUCB2/NESF-1 plays a crucial role in cancer development and progression. High expression of NUCB2/NESF-1 is associated with poor outcomes in various cancers and promotes cell proliferation, migration, and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rafal Lenda, Michal Padjasek, Artur Krezel, Andrzej Ozyhar, Dominika Bystranowska
Summary: This study analyzed the effect of Zn(II) and Ca(II) on the structure of human nesfatin-1, -2, and -1/2. The results revealed that human nesfatin-1 is an intrinsically disordered protein, while nesfatin-2 and nesfatin-1/2 have globular structures with intrinsically disordered regions. Zn(II) treatment led to structurization and compaction of nesfatin-1, as well as destabilization of nesfatin-2 and nesfatin-1/2. Furthermore, nesfatin-1 and -2 seemed to be interdependent when linked together, as the properties of nesfatin-1/2 were not a simple sum of the properties exhibited by the individual peptides.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Yunlai Liang, Yating Ma, Kun Wang, Manglin Xiang, Bin Yi
Summary: The association of NUCB-2/Nesfatin-1 with nasopharyngeal carcinoma was unclear, so this study aimed to clarify its role in the development, progression, and diagnosis of NPC. The results showed that NUCB-2 level was higher in NPC tissue than in rhinitis tissue, and suppression of NUCB-2 inhibited NPC cell proliferation while improvement of NUCB-2 promoted cell propagation. Moreover, serum NUCB-2 level could potentially be a serological marker for the early diagnosis of nasopharyngeal carcinoma.
CANCER CELL INTERNATIONAL
(2023)
Article
Plant Sciences
Jing Xu, Chaofan Fu, Tao Li, Xiaoyan Xia, Huixing Zhang, Xude Wang, Yuqing Zhao
Summary: The study found that AE inhibited apoptosis and increased antioxidant levels in STZ-induced MIN6 cells. In the diabetic rat model, the AE group showed lower blood glucose levels, increased insulin secretion, and alleviated weight loss.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Siyi Ning, Caiying Liu, Kangtao Wang, Yubo Cai, Zhicheng Ning, Ming Li, Liang Zeng
Summary: NUCB2/Nesfatin-1 promotes breast cancer metastasis by reprogramming cholesterol metabolism. NUCB2/Nesfatin-1 is overexpressed in breast cancer patients and is associated with poor prognosis. Mechanistically, NUCB2/Nesfatin-1 upregulates cholesterol synthesis via the mTORC1 signal pathway, contributing to breast cancer migration and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Physiology
Vi Pham, Joshua G. Pemberton, John P. Chang, Ayelen Melisa Blanco, Atefeh Nasri, Suraj Unniappan
Summary: This study provides evidence that nesfatin-1 is a stress responsive peptide which modulates stress axis hormones in fish. It was found that nesfatin-1 affects cortisol release, ACTH secretion, and mRNA levels of CRF in various tissues of goldfish under stress conditions. The presence of nucb2/nesfatin-1-like immunoreactivity in the hypothalamus, pituitary, and interrenal cells points to the potential role of nesfatin-1 in regulating the HPI axis.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Cell Biology
Jasmine Hui, Gurpreet Kaur Aulakh, Suraj Unniappan, Baljit Singh
Summary: Deletion of the NUCB2/nesfatin-1 gene led to an increase in accumulation of adherent neutrophils in the lungs of NKO mice, suggesting an anti-inflammatory role of NUCB2/nesfatin-1 in acute lung inflammation.
CELL AND TISSUE RESEARCH
(2021)
Article
Oncology
Noriko Tagawa, Honoka Ogura, Hikaru Miyawaki, Akihiro Asakawa, Ikuo Kato
Summary: This study found that peripheral administration of nesfatin-1 increased blood concentrations of GLP-1 and insulin, and decreased blood glucose concentrations in food-deprived mice. Furthermore, the study demonstrated that nesfatin-1 increased insulin concentrations by accelerating GLP-1 secretion. These findings suggest the potential therapeutic value of nesfatin-1 for GLP-1 release.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Aristea Psilopanagioti, Sofia Nikou, Souzana Logotheti, Marina Arbi, Dionysios V. Chartoumpekis, Helen Papadaki
Summary: The study focuses on the expression of GLP-1R in the human hypothalamus and its relationship with BMI. The results suggest that GLP-1R may play a role in regulating energy balance in the human hypothalamus, particularly in the LH region, which is associated with appetite and reward. The study also indicates a potential interaction between GLP-1R and nucleobindin-2/nesfatin-1 in signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sophia Kristina Rupp, Andreas Stengel
Summary: Studies have shown that NUCB2/nesfatin-1 is widely distributed in the brain and spinal cord and plays a role in autonomic regulation, with nesfatin-1 modulating autonomic functions in various regions. Additionally, the autonomic nervous system influences the activity of nesfatin-1 neurons, with the vagus nerve playing a crucial role in nesfatin-1 regulation. While data is still limited, research has clearly demonstrated the complex interplay between nesfatin-1 and the autonomic nervous system.
Article
Agriculture, Dairy & Animal Science
Jithine Jayakumar Rajeswari, Suraj Unniappan
Summary: The study found that nesfatin-1 and Nlp can stimulate insulin production in adipose tissue and modulate growth hormone and insulin-like growth factors and glucose transporters in goldfish. These results strongly support the tissue-specific regulatory roles of nesfatin-1 and Nlp in growth and glucose metabolism in goldfish.
Review
Biochemistry & Molecular Biology
Saleh Rahmati, Behnam Mohammadi, Zahra Karimi-Mehr, David Robert Broom
Summary: The aim of this rapid review is to assess the impact of physical activity and exercise on NUCB2 gene expression and Nesfatin-1 concentration. Human studies show that Nesfatin-1 concentration either remains unchanged or increases after exercise training, with higher intensity and longer duration of exercise training leading to a greater increase. Animal studies using mouse models generally demonstrate increased tissue NUCB2/Nesfatin-1 with regular exercise training. However, there is a lack of research on the acute response and biopsy studies in humans, as well as investigations on the effects of acute exercise in animals. Comparative studies and further research are recommended to enhance our understanding of the effects of exercise on NUCB2/Nesfatin-1 in humans and animals.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Cell Biology
Anna Skorupska-Stasiak, Dominika Bystranowska, Jozef Ba Tran, Artur Krezel, Andrzej Ozyhar
Summary: This study investigated the structural and biochemical properties of the C-terminal half of Nucb2 and found that its product, nesfatin-3, had completely different properties from its precursor protein. Despite their similarities, nesfatin-3 is likely to play different roles in physiological processes and have different effects on tissue function, metabolism, and its regulation. The results of this study clearly demonstrated that nesfatin-3 possesses divalent metal ion binding properties that were not found in the nucleobindin-2 precursor protein.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Endocrinology & Metabolism
James M. Fulcher, Adam C. Swensen, Yi-Chun Chen, C. Bruce Verchere, Vladislav A. Petyuk, Wei-Jun Qian
Summary: This study investigated the forms and quantities of improperly processed insulin and other hormone products following carboxypeptidase E (CPE) deletion in pancreatic islets using top-down proteomics. The results showed an increase in dibasic residue-containing proinsulin and other proteoforms of improperly processed proinsulin, suggesting novel substrates of CPE. Interestingly, some known substrates of CPE remained unaffected, implying compensatory mechanisms by paralogous processing enzymes. This study provides unique insights into the complexity of hormone processing products and the regulatory mechanisms.
Article
Cell Biology
Xadeni Burgos-Gamez, Paulina Morales-Castillo, Cristina Fernandez-Mejia
Summary: During lactation, the maternal physiology adapts to meet the nutritional needs of the offspring, with the pancreas playing a central role in digestion and metabolism. Recent studies have uncovered the molecular mechanisms involved in the endocrine pancreas during breastfeeding, as well as unexpected changes in the pancreas at the end of lactation and after weaning. This review aims to gather information on these changes and their impact on glucose homeostasis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)