Article
Fisheries
Zhaosheng Sun, Yuting Qin, Danjie Liu, Bangjie Wang, Zhao Jia, Junya Wang, Qian Gao, Jun Zou, Yue Pang
Summary: Chemokines are soluble peptides that guide cell migration in development and immune defense. The CXC chemokine system in lamprey has been found to have diversified, showing variations in gene organization and expression patterns in different tissues, indicating an evolutionary adaptation in jawless fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Soudeh Ghafouri-Fard, Kasra Honarmand, Mohammad Taheri
Summary: Multiple sclerosis (MS) is considered to be a chronic inflammatory disorder of the central nervous system caused by abnormal immune responses. Chemokines play an important role in the pathogenesis of MS, with several members of this family being dysregulated in MS patients' peripheral blood, cerebrospinal fluid, or CNS lesions. Studies in animal models have shown the critical roles of chemokines in the pathophysiology of MS.
METABOLIC BRAIN DISEASE
(2021)
Review
Immunology
Gertraud Orend, Richard P. Tucker
Summary: Tenascin-C plays important roles in immunity, interacting with Toll-like receptor 4, integrin alpha 9 beta 1, and chemokines. While tenascins predate the appearance of adaptive immunity, the first tenascin-C appears to have evolved in early chordate lineages. Adaptive immunity evolved independently in jawless and jawed vertebrates, with the former using variable lymphocyte receptors and the latter using immunoglobulins.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geosciences, Multidisciplinary
Zhaohui Pan, Zhibin Niu, Zumin Xian, Min Zhu
Summary: Antiarcha data are crucial for quantitative studies of basal jawed vertebrates. The lack of structured data on key groups of early vertebrates, such as Antiarcha, has hindered our understanding of their diversity and distribution patterns. This study presents an unprecedented open-access Antiarcha dataset, including 60 genera and 6025 specimens spanning from the Ludfordian to the Famennian globally. The dataset, curated by an expert team, offers great research potential in testing qualitative hypotheses on biodiversity changes, spatiotemporal distribution, evolution, and community composition.
EARTH SYSTEM SCIENCE DATA
(2023)
Article
Biochemistry & Molecular Biology
Mengdan Dong, Hong Zhang, Chengyu Mo, Wenjing Li, Wanwan Zhang, Kuntong Jia, Wei Liu, Meisheng Yi
Summary: CXC chemokine signaling plays a crucial role in wound healing processes. Through de novo transcriptome sequencing, ten differentially expressed BsCXCRs were identified in skin ulcerated four-eyed sleeper fish. These receptors are mainly located in muscle and immune-related organs in healthy fish, but transiently upregulated in injured fish within one hour post-injury, suggesting their involvement in the early inflammatory response to skin injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Li-guo Ding, Guang-kun Han, Xin-you Wang, Ru-han Sun, Yong-yao Yu, Zhen Xu
Summary: This study investigated the composition of the teleost gallbladder microbiota and its potential role in mucosal immunity. The results showed that the gallbladder microbiome was similar to the gut microbiota. Infection induced inflammation and disrupted microbial homeostasis in the gallbladder. Beneficial bacteria from the Lactobacillales order increased in abundance in the bile microbial community, while the structure of the Mycoplasmatales order in the gut microbial community changed significantly.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Respiratory System
Lian-Tao Hu, Wen-Jun Deng, Zhen-Sheng Chu, Luo Sun, Chun-Bin Zhang, Shi-Zhen Lu, Jin-Ru Weng, Qiao-Sheng Ren, Xin-Yu Dong, Wei-Dong Li, Xue-Bin Li, Yun-Ting Du, Yue Li, Wei-Qun Wang
Summary: The expression profiles and prognostic values of CXCR members in lung adenocarcinoma (LUAD) were explored using multiple public databases. The results showed altered expression levels of CXCRs in LUAD tissues and their association with prognosis and immune infiltration.
BMC PULMONARY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu
Summary: The study found that spike-specific CXCR3(+) T-FH cells play a crucial role in antibody maintenance and recall responses after SARS-CoV-2 infection and vaccination, exhibiting a more durable response and better ability to induce antibody secretion.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Editorial Material
Multidisciplinary Sciences
Matt Friedman
Summary: Scarce evidence suggests that important evolutionary developments for jawed vertebrates may have taken place during or prior to the Silurian period. Fossil discoveries unveil insights into this particular interval.
Article
Biochemistry & Molecular Biology
Maria E. Velizhanina, Alexey P. Galkin
Summary: This study found that the FXR1 protein in various vertebrates possesses amyloid properties, and these properties have existed for at least 365 million years. This discovery is of significant importance for understanding the regulatory role of FXR1 amyloid fibrils in the vertebrate brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Chuanjie Qin, Nazakat Hussain Memon, Quan Gong, Qinchao Shi, Qingfa Yang
Summary: The interaction of CXC chemokine ligand 12/CXC receptor 4 ligand/receptor in the immune system plays a crucial role in response against bacterial infection in vertebrates. The study on Pelteobagrus vachellii revealed a 24-hour variation in the expression of CXCR4 and CXCL12 genes, highlighting the importance of understanding the immune rhythm in teleosts.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Fisheries
Dan Qiao, Yanjing Zhao, Chao Pei, Xianliang Zhao, Xinyu Jiang, Lei Zhu, Jie Zhang, Li Li, Xianghui Kong
Summary: This study identified and characterized 61 CC chemokines from allotetraploid common carp, revealing their unique features in cell migration, gene arrangement, and chromosomal location. Additionally, the study predicted and verified the antimicrobial activity of certain CC chemokines, highlighting their important role in immune system evolution and pathogen infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Fuyu Jin, Yaqian Li, Xuemin Gao, Xinyu Yang, Tian Li, Shupeng Liu, Zhongqiu Wei, Shifeng Li, Na Mao, Heliang Liu, Wenchen Cai, Hong Xu, Haibo Zhang
Summary: Exercise training has the potential to mitigate the progression of silicosis by suppressing the SRB/NLRP3 and TLR4 pathways. Macrophage-derived IL-17A plays a key role in silica-induced pulmonary inflammation and fibrosis. Exercise training effectively inhibits the IL-17A-CXCL5-CXCR2 axis in silicotic mice, reducing collagen deposition and preserving elastic fibers, ultimately slowing down pulmonary fibrosis advancement and improving lung function post silica exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Anthony K. Redmond, Aoife McLysaght
Summary: This study demonstrates significant progress in partitioned phylogenomic analysis by using site-heterogeneous models and amino acid recoding to alleviate branching artefacts caused by systematic errors. The reanalysis of key datasets shows that partitioned phylogenomics does not support comb jellies as sister to other animals. Branching artefacts can confound the reconstruction of deep evolutionary relationships.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Milton Tan, Anthony K. Redmond, Helen Dooley, Ryo Nozu, Keiichi Sato, Shigehiro Kuraku, Sergey Koren, Adam M. Phillippy, Alistair D. M. Dove, Timothy Read
Summary: This study reported the long-read sequencing of the whale shark genome, providing the best chondrichthyan genome assembly and studying the genomic evolution of ancestral gene families, immunity, and giant vertebrates. The research found a significant increase in gene families at the origin of jawed vertebrates.
Review
Immunology
Katherine M. Buckley, Helen Dooley
Summary: The ongoing arms race between hosts and microbes has driven the evolution of novel strategies for diversifying immune response molecules. Different organisms have different mechanisms for generating and maintaining diversity. In addition to pathogen detection, immunological diversity also plays important roles in allorecognition systems.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Fiona K. Bakke, Manu Kumar Gundappa, Hanover Matz, David A. Stead, Daniel J. Macqueen, Helen Dooley
Summary: This study used mass spectrometry-based proteomics to identify and quantify candidate immune proteins in the plasma of nurse sharks. By integrating transcriptome data, they identified 626 plasma proteins and discovered some proteins involved in the immune response. This research enhances genetic and protein-level resources for nurse shark research and improves our understanding of elasmobranch plasma proteome.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Kritika Srinivasan Rajsri, Michael P. McRae, Glennon W. Simmons, Nicolaos J. Christodoulides, Hanover Matz, Helen Dooley, Akiko Koide, Shohei Koide, John T. McDevitt
Summary: This article introduces a rapid diagnostic method that can quantitatively measure SARS-CoV-2 antibodies. This method could help clinicians make decisions on booster shots and assess convalescent plasma donors, as well as enable researchers to measure antibody levels against new viral variants in immunized or infected individuals.
Article
Immunology
Anthony K. Redmond, Rita Pettinello, Fiona K. Bakke, Helen Dooley
Summary: In this study, the TNFSF repertoires of five cartilaginous fish genomes were analyzed. It was found that sharks have more TNFSF genes, with about 30 genes, compared to any other vertebrate species. This suggests that the ancestral jawed vertebrate had a larger and more diverse TNFSF repertoire than previously thought, challenging the notion that the cartilaginous fish immune system is primitive compared to mammals.
JOURNAL OF IMMUNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Anthony K. Redmond, Aoife McLysaght
NATURE COMMUNICATIONS
(2022)
Letter
Multidisciplinary Sciences
Anthony K. Redmond, Aoife McLysaght
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Anthony K. Redmond, Dearbhaile Casey, Manu Kumar Gundappa, Daniel J. Macqueen, Aoife McLysaght
Summary: Whole genome duplication (WGD) is an important event in evolution, generating new genes and potentially promoting survival during mass extinctions. Paddlefish and sturgeon, sister lineages, show genomic evidence of ancient WGD. Although the duplications appear to be independent, they actually stem from a shared WGD event over 200 million years ago, prior to the Permian-Triassic extinction. The shared WGD is masked by lineage divergence before the completion of rediploidization.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Kritika Srinivasan Rajsri, Michael P. McRae, Nicolaos J. Christodoulides, Isaac Dapkins, Glennon W. Simmons, Hanover Matz, Helen Dooley, David Fenyo, John T. McDevitt
Summary: As COVID-19 public health measures are being eased globally, the emergence of new SARS-CoV-2 strains continues to pose a high risk for vulnerable populations. The waning of antibody-mediated protection acquired from vaccination and/or infection and the ineffectiveness of monoclonal antibody prophylaxis in immunocompromised populations necessitate the monitoring of new variants and their impact on vaccine performance. Screening methods such as surveillance of new SARS-CoV-2 infections and serology testing are gaining consensus, particularly for at-risk groups.
BIOENGINEERING-BASEL
(2023)
Letter
Multidisciplinary Sciences
Anthony K. Redmond, Aoife McLysaght
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Hanover Matz, Richard S. Taylor, Anthony K. Redmond, Thomas M. Hill, Rose Ruiz Daniels, Mariana Beltran, Neil C. Henderson, Daniel J. Macqueen, Helen Dooley
Summary: By studying the spleens of nurse sharks, we found that sharks are capable of producing robust antigen-specific responses and affinity maturation of B cells, despite the absence of germinal centers (GCs) observed in other animals. We also identified immune-related marker gene expression in the spleen cells of sharks and tracked their localization in the splenic follicles. These findings provide insights into the evolutionary foundation of GCs.
Meeting Abstract
Immunology
Hanover C. Matz, Helen Dooley
JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
