期刊
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
卷 99, 期 1, 页码 4-9出版社
WILEY
DOI: 10.1111/iep.12265
关键词
extracellular matrix; integrins; vesicular trafficking; mTOR; nutrient signalling; cell metabolism
类别
资金
- University of Sheffield
- Royal Society
Integrins are the key mediators of cell-extracellular matrix (ECM) interaction, linking the ECM to the actin cytoskeleton. Besides localizing at the cell surface, they can be internalized and transported back to the plasma membrane (recycled) or delivered to the late endosomes/lysosomes for degradation. We and others have shown that integrin can be endocytosed together with their ECM ligands. In this short review, I will highlight how extracellular protein (including ECM) endocytosis impinges on the activation of the mechanistic target of rapamycin (mTOR) pathway, a master regulator of cell metabolism and growth. This supports the intriguing hypothesis that ECM components may be considered as nutrient sources, primarily under soluble nutrient-depleted conditions.
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