Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice

Editorial (Thematic Issue: “Nanosize Drug Delivery System”)

(2014) Biswajit Mukherjee   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Quaternized starch-based carrier for siRNA delivery: From cellular uptake to gene silencing

(2014) Eliz Amar-Lewis et al.   JOURNAL OF CONTROLLED RELEASE

Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles

(2014) Shoshy Mizrahy et al.   Nanoscale

Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response

(2013) Matthew R. Pawlus et al.   CELLULAR SIGNALLING

Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis

(2013) Xuli Zhao et al.   CURRENT DRUG TARGETS

BRG1 and BRM Chromatin-Remodeling Complexes Regulate the Hypoxia Response by Acting as Coactivators for a Subset of Hypoxia-Inducible Transcription Factor Target Genes

(2013) J. A. Sena et al.   MOLECULAR AND CELLULAR BIOLOGY

In Vivo Tumor Detection Using Polarization and Wavelength Reflection Characteristics of Gold Nanorods

(2013) Dror Fixler et al.   NANO LETTERS

STAT3 or USF2 Contributes to HIF Target Gene Specificity

(2013) Matthew R. Pawlus et al.   PLoS One

Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2  (HIF2 ) Cooperatively Activate HIF2 Target Genes during Hypoxia

(2012) M. R. Pawlus et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

Hypoxia-inducible factors: Crosstalk between inflammation and metabolism

(2012) Jessica E.S. Shay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis

(2011) S. Veenbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

(2011) Eiji Kozawa et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display

(2011) Yanbin Pi et al.   BIOMATERIALS

Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

(2011) J-H Ryu et al.   CELL DEATH AND DIFFERENTIATION

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

(2010) Nahid Akhtar et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

HIF-2α - a mediator of osteoarthritis?

(2010) Christopher L Murphy   CELL RESEARCH

Intra-articular lentivirus-mediated delivery of galectin-3 shRNA and galectin-1 gene ameliorates collagen-induced arthritis

(2010) C-R Wang et al.   GENE THERAPY

Targeted nanodelivery of drugs and diagnostics

(2010) Margaret A. Phillips et al.   Nano Today

Shifting HIFs in osteoarthritis

(2010) Matthew Husa et al.   NATURE MEDICINE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

HIF2α central player in osteoarthritis

(2010) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rabbit

(2010) S. Laverty et al.   OSTEOARTHRITIS AND CARTILAGE

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

(2009) Vijaykumar M. Baragi et al.   ARTHRITIS AND RHEUMATISM

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Alterations in the vimentin cytoskeleton in response to single impact load in an in vitro model of cartilage damage in the rat

(2008) Frances MD Henson et al.   BMC MUSCULOSKELETAL DISORDERS

Multi-functional nanocarriers for targeted delivery of drugs and genes

(2008) Lara Jabr-Milane et al.   JOURNAL OF CONTROLLED RELEASE

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-κBp65-specific siRNA

(2007) L.X. Chen et al.   OSTEOARTHRITIS AND CARTILAGE