期刊
GENE
卷 557, 期 2, 页码 113-122出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2014.12.020
关键词
Ubiquitin; Ubiquitin protein ligases; NEDD4 family; IGF signalling; PTEN
资金
- National Health and Medical Research Council (NHMRC) Project [1020755, 1059393]
- NHMRC [1002863]
- National Health and Medical Research Council of Australia [1059393] Funding Source: NHMRC
Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the pathophysiological significance of this important ubiquitin ligase. (C) 2014 Elsevier B.V. All rights reserved.
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