Article
Health Care Sciences & Services
Elena-Daniela Grigorescu, Cristina-Mihaela Lacatusu, Mariana Floria, Georgiana-Diana Cazac, Alina Onofriescu, Alexandr Ceasovschih, Ioana Cretu, Bogdan-Mircea Mihai, Laurentiu Sorodoc
Summary: This study found a higher prevalence of MAC in T2DM patients than previously reported, with insulin resistance and inflammation being predictive factors for MAC, although significant markers differ across studies. This suggests that widely available screening methods can help in the early identification of MAC in diabetes patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Aku Enam Motto, Povi Lawson-Evi, Kwashie Eklu-Gadegbeku
Summary: This study evaluated the antidiabetic properties of hydro alcoholic extract and supernatant fraction of Anogeissus leiocarpus roots. The extract and supernatant showed significant decrease in blood glucose level, improvement in lipid profile, and increased antioxidant potential in diabetic rats. The supernatant fraction exerted stronger antidiabetic and antioxidant effects than the total extract.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Babiker Saad Almugadam, Peng Yang, Li Tang
Summary: The study revealed a significant decrease in richness and diversity of jejunum microbiota in T2DM, while Ceftriaxone sodium-induced gut dysbiosis reduced food-water intake and affected microbiota diversity, along with diabetic parameters.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Health Care Sciences & Services
Alvaro Astasio-Picado, Alba angel Babiano, Miriam Lopez-Sanchez, Rocio Ruiz Lozano, Paula Cobos-Moreno, Beatriz Gomez-Martin
Summary: This article provides evidence on the effectiveness and safety of ozone therapy in the treatment of wounds in patients with diabetic foot. It compares ozone therapy with other treatment methods and presents the findings of a literature review.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sohail Akhtar, Mujahid Latif, Omer Shabbir Ahmed, Aqsa Sarwar, Ayisham Alina, Muhammad Imran Khan
Summary: This study explores the prevalence of foot ulcers among diabetic patients in Punjab, Pakistan and identifies associated factors. The results indicate a relatively high prevalence of foot ulcers in Punjab, highlighting the need for better strategies and preventive measures to address this epidemic.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Dermatology
Mohamed S. Imam, Ahmed Khalid Almutairi, Abdullah Mutrik Alhajri, Mishary Mosleh Alharby, Mohammed H. Alanazi, Ahmad G. Alotaibi, Mohamed E. A. Abdelrahim
Summary: This meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. The results showed that hyperbaric oxygen treatment had significantly higher rates of healed ulcers, adverse events, and ulcer area reduction, as well as lower mortality, compared to standard treatment. However, there was no significant difference in amputation and healing time between the two treatments. It is important to note that the selected studies had small sample sizes and limited comparisons.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Sujit Kumar Das, Pinki Roy, Prabhishek Singh, Manoj Diwakar, Vijendra Singh, Ankur Maurya, Sandeep Kumar, Seifedine Kadry, Jungeun Kim
Summary: Diabetes is a chronic condition caused by uncontrolled blood sugar levels, and early diagnosis of complications such as diabetic foot ulcers (DFUs) can help prevent severe consequences. The use of deep learning, machine learning, and computer vision techniques provides promising solutions for assisting clinicians in diagnosing DFUs. This article provides a comprehensive overview of the current status of automatic DFU identification and highlights the dominance of CNN-based solutions in the field. It emphasizes the importance of combining traditional ML and advanced DL techniques for more reliable and efficient diagnostic decisions.
Review
Medicine, Research & Experimental
Yujia Zhang, Jing Zhang, Zhou Xu, Deju Zhang, Panpan Xia, Jitao Ling, Xiaoyi Tang, Xiao Liu, Rui Xuan, Meiying Zhang, Jianping Liu, Peng Yu
Summary: Non-coding RNA (ncRNA) is a significant component of the human genome, controlling various biological processes. It plays a crucial role in the onset and development of diabetes-related complications, such as diabetic foot ulcer (DFU). Understanding the mechanism and progress of ncRNA-protein binding in DFU can contribute to the early diagnosis and targeted intervention of DFU.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Spectroscopy
Bhavya Srivastava, Souvik Sen, Santanu Bhakta, Kamalika Sen
Summary: The study focused on analyzing sorbitol levels in diabetic blood samples and comparing them with non-diabetic samples, as well as studying the reduction in sorbitol levels upon the addition of caffeine. The results showed that caffeine could potentially help reduce sorbitol levels in diabetic patients, thus controlling the development and progression of diabetic neuropathy.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Medicine, General & Internal
Wei Chai, Yuqing Wang, Huancheng Zheng, Song Yue, Yan Liu, Yili Wu, Xuezhi Li
Summary: The study analyzed the pathogen spectrum and antibiotic susceptibility of diabetic foot ulcers, finding that dominant pathogens were sensitive to at least one antibiotic, but the antibacterial efficacy of common antibiotics decreased over time. Identification and testing of antibiotic susceptibility of dominant pathogens are essential for effective treatment of diabetic foot ulcers.
FRONTIERS IN MEDICINE
(2021)
Article
Dermatology
Deborah Christensen, Albert Botchway
Summary: A retrospective chart cohort review over 3 years shows that using a felt foot plate can effectively heal a diabetic foot ulcer, and patient weight and growth factors do not affect healing times.
ADVANCES IN SKIN & WOUND CARE
(2023)
Article
Dermatology
Liu He, Ya-Qing Xia, Cai-Feng Yang, Jia-Li He, Xian-Yu Tang
Summary: A meta-analysis was conducted to evaluate the management of diabetic foot wound ulcers (DFWUs) using laser therapy (LT). The results showed that LT had a significant effect on reducing ulcer size and promoting complete healing in individuals with DFWUs compared to control. However, caution should be exercised in interpreting the results due to the small sample size of the selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Medicine, General & Internal
Jean-Baptiste Bonnet, Ariane Sultan
Summary: The diabetic foot ulcer (DFU), a common and serious complication of diabetes, is influenced by the individual's social environment and access to healthcare. Financial insecurity and social protection systems play a significant role in DFU prognosis, while the relationship between socioeconomic and socio-educational deprivations and DFU is more complex. Understanding the correlation between DFU risk and social deprivation depends on how social deprivation is calculated and how questions about the relationship are framed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Vijay Viswanathan, Sukanya Nachimuthu
Summary: People with diabetes have a higher risk of lower-limb amputations. The risk of avoidable lower-limb amputations has increased during the COVID-19 lockdown. Factors such as missed hospital visits, improper diet, nonadherence to medications, and physical inactivity may contribute to this increase.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2023)
Review
Pharmacology & Pharmacy
Thangaraj Abiramalatha, Viraraghavan Vadakkencherry Ramaswamy, Anand Kumar Ponnala, Venkat Reddy Kallem, Yogeshkumar Murkunde, Alan Mathew Punnoose, Aravindhan Vivekanandhan, Abdul Kareem Pullattayil, Prakash Amboiram
Summary: This systematic review evaluates interventions in preclinical studies for their neuroprotective effects against PVL, highlighting stem cells, erythropoietin, and melatonin as potential therapies with promising outcomes. With most interventions showing only partial efficacy, it is suggested that future research should focus on combination treatments and personalized approaches tailored to different subgroups of preterm neonates.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Pharmacology & Pharmacy
Suchitra Mohanty, Poonam Yadav, Harini Lakshminarayanan, Priyanshu Sharma, Aravindhan Vivekanandhan, Devarajan Karunagaran
Summary: The study found that RETRA selectively induces necroptosis in cervical cancer cells without cytotoxic effects on normal cells. The induction of cell death by RETRA is associated with mitochondrial hyperpolarization and increased ROS production, emphasizing its importance in the treatment of cervical cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Correction
Endocrinology & Metabolism
Arutselvi Devarajan, Satyavani Kumpatla, Vijay Viswanathan
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Endocrinology & Metabolism
Arutselvi Devarajan, Satyavani Kumpatla, Vijay Viswanathan
Summary: This study aimed to explore the profile, regular hospital visits, glucose monitoring, and treatment outcomes among people with type 1 diabetes in India. The results showed that individuals who made regular hospital visits and practiced self-monitoring of blood glucose had fewer complications.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Endocrinology & Metabolism
Anu Maria Jacob, Arutselvi Devarajan, Sukanya Nachimuthu, Manjula Datta, Vijay Viswanathan
Summary: The study aimed to estimate the direct and indirect cost of treating diabetes among people living in low resource urban setting. It found that individuals living with diabetes in this setting spent more on direct medical cost, with out of pocket expenditure mainly on hospitalization, followed by medicines and investigations. Strengthening and provision of appropriate primary public health care services for diabetes may reduce out of pocket expenditure in private health care facilities.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Endocrinology & Metabolism
Vivekanandhan Aravindhan, Anup Bobhate, Kuppan Sathishkumar, Vijay Viswanathan
Summary: IL-38, a novel anti-inflammatory cytokine, may play a crucial role in the diabetes-tuberculosis nexus.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Multidisciplinary Sciences
A. G. Unnikrishnan, R. K. Sahay, Uday Phadke, S. K. Sharma, Parag Shah, Rishi Shukla, Vijay Viswanathan, S. K. Wangnoo, Santosh Singhal, Mathew John, Ajay Kumar, Mala Dharmalingam, Subodh Jain, Shehla Shaikh, Willem J. Verberk
Summary: Through studying newly diagnosed T2DM patients in India, it is found that they have high cardiovascular disease risk. This indicates the need for further extension of ASCVD risk identification programs and prevention strategies to reduce the occurrence of cardiovascular diseases.
Article
Endocrinology & Metabolism
Ambika Gopalakrishnan Unnikrishnan, Vijay Viswanathan, Fang Liz Zhou, Lichen Hao, Prithvi Kamath, Monica Bertolini, Jose Fernando Botero, Leonardo Mancillas-Adame
Summary: This study assessed the impact of MDC usage frequency on clinical outcomes in patients with type 2 diabetes. The results showed that high frequency usage was associated with better achievement of blood glucose targets and faster time to target, without increasing the risk of hypoglycemia.
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Vivekanandhan Aravindhan, Anup Bobhate, Kuppan Sathishkumar, Aruna Patil, Satyavani Kumpatla, Vijay Viswanathan
Summary: This study investigated the prevalence of latent tuberculosis infection (LTBI) among diabetes patients and the relationship with immunoendocrine biomarkers.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ali A. Rizvi, Amita Kathuria, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Andrej Janez, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The COVID-19 pandemic has been impacting the world for three years. The SARS CoV 2 virus spreads rapidly and has a high morbidity and mortality in individuals with risk factors. After the acute phase, patients may experience long-term symptoms known as Long COVID or Post-COVID Syndrome, which may be caused by chronic inflammation and immunologic state. The prediction, course, and management of COVID-related hyperglycemia and diabetes still need further elucidation.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Hardy Kornfeld, Elizabeth Procter-Gray, Satyavani Kumpatla, Kevin Kane, Wenjun Li, Matthew J. Magee, Subash Babu, Vijay Viswanathan
Summary: This study aimed to investigate the impact of pulmonary TB on glycemic status, as well as the associations of glycemic trends with antidiabetic therapy and TB outcomes. Data from two prospective cohort studies in Chennai, India were analyzed and it was found that baseline A1C levels decreased after TB treatment initiation in all groups. However, in patients with baseline diabetes, rising A1C levels during and after treatment were significantly associated with adverse TB outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Mainas, Luigi Nibali, Mark Ide, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Alberto Firenze, Massimo Galia, Su-Yen Goh, Andrej Janez, Sanjay Kalra, Nitin Kapoor, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Amirhossein Sahebkar, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: Periodontitis is a disease that leads to the loss of periodontal attachment and bone resorption. COVID-19 is a contagious disease caused by SARS-CoV-2. Investigations have shown a possible relationship between periodontitis and COVID-19, as both conditions can lead to cardiometabolic impairments. This review aims to summarize the existing evidence regarding the link between periodontitis and COVID-19 and their associated complications.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
