Article
Cardiac & Cardiovascular Systems
Teruaki Wada, Yasutsugu Shiono, Takashi Kubo, Kentaro Honda, Masahiro Takahata, Kunihiro Shimamura, Mitsuru Yuzaki, Takashi Tanimoto, Yoshiki Matsuo, Atsushi Tanaka, Takeshi Hozumi, Yoshiharu Nishimura, Takashi Akasaka
Summary: The study aimed to assess the impact of instantaneous wave-free ratio (iFR) on graft failure after coronary artery bypass grafting (CABG). The results showed that graft failure rates were significantly higher in vessels with negative iFR (>0.89) compared to those with positive iFR (<0.89).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Jincheng Liu, Bao Li, Yanping Zhang, Liyuan Zhang, Suqin Huang, Hao Sun, Jian Liu, Xi Zhao, Mingzi Zhang, Wenxin Wang, Youjun Liu
Summary: This study proposed a high-fidelity geometric multiscale model (HFMM) to characterize coronary pressure and flow under the resting state, aiming to better predict myocardial ischemia using CT-iFR. Through prospective enrollment of 57 patients, it was found that CT-iFR had greater accuracy in identifying myocardial ischemia compared to CCTA and CT-FFR. Furthermore, the computational time of CT-iFR was faster.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Soohong Min, Gwansuk Kang, Dong-Guk Paeng, Joon Hyouk Choi
Summary: The study aimed to predict wedge pressure using wave separation analysis and investigate its impact on FFR and iFR. Results showed high correlations between FFR and reconstructed FFR, as well as between iFR and reconstructed iFR. This suggests that FFR and iFR can be expressed as variations in trans-stenotic forward pressure derived from the same formula.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Stephanie C. El Hajj, Takumi Toya, Takayuki Warisawa, John Nan, Bradley R. Lewis, Christopher M. Cook, Christopher Rajkumar, James P. Howard, Henry Seligman, Yousif Ahmad, Shunichi Doi, Akihiro Nakajima, Masafumi Nakayama, Sonoka Goto, Rafael Vera-Urquiza, Takao Sato, Yuetsu Kikuta, Yoshiaki Kawase, Hidetaka Nishina, Sunao Nakamura, Hitoshi Matsuo, Javier Escaned, Yoshihiro J. Akashi, Justin E. Davies, Amir Lerman
Summary: This international multicenter study evaluated the use of iFR in assessing angiographically intermediate LMCD. Results showed that an iFR of <= 0.89 correlates with intravascular ultrasound minimum lumen area <6 mm(2), regardless of body surface area. The study supports the use of iFR for the evaluation of intermediate LMCD.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Jingyuan Zhang, Kun Xu, Yumeng Hu, Lin Yang, Xiaochang Leng, Hongfeng Jin, Yiming Tang, Xiaowei Liu, Chen Ye, Yitao Guo, Lei Wang, Jianjun Zhang, Yue Feng, Caiyun Mou, Lijiang Tang, Jianping Xiang, Changqing Du
Summary: AccuiFRct, a novel CT-iFR method based on deep learning and computational fluid dynamics, showed good correlation with invasive FFR and iFR, demonstrating its potential as a noninvasive tool for detecting ischemia-causing coronary lesions and aiding in clinical decision-making.
BMC CARDIOVASCULAR DISORDERS
(2022)
Review
Cardiac & Cardiovascular Systems
Anselm W. Stark, Andreas A. Giannopoulos, Alexander Pugachev, Isaac Shiri, Andreas Haeberlin, Lorenz Raber, Dominik Obrist, Christoph Grani
Summary: This systematic review examines the role of computational fluid dynamics (CFD) simulations in the assessment of anomalous aortic origin of a coronary artery (AAOCA). The review found that CFD simulations offer a noninvasive alternative for patient-specific hemodynamic analysis in AAOCA. However, both dedicated and general-purpose CFD models have limitations and further research is needed to accurately simulate the pathophysiological changes in AAOCA.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Hernan Mejia-Renteria, Daniel Faria, Joo Myung Lee, Seung Hun Lee, Ji-Hyun Jung, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Masahiro Hoshino, Tomoyo Sugiyama, Yoshihisa Kanaji, Nieves Gonzalo, Tsunekazu Kakuta, Bon-Kwon Koo, Javier Escaned
Summary: The effect of aging on coronary stenosis functional assessment with FFR and iFR was investigated. FFR values increased with age, while iFR values remained unchanged. In patients over 60 years old, revascularization deferral based on FFR, along with abnormal iFR and CFR values, was associated with worse long-term patient outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Computer Science, Interdisciplinary Applications
Anthony Aubry, Hamid R. Karbasian, Brian C. Vermeire
Summary: This paper demonstrates the use of Large Eddy Simulation (LES) and the Mesh Adaptive Direct Search (MADS) optimization algorithm for shape optimization of Low Pressure Turbine (LPT) cascades. The results show that using LES for LPT cascade optimization is feasible and can lead to significant improvements in performance.
COMPUTERS & FLUIDS
(2022)
Article
Engineering, Civil
Jesper Roland Kjaergaard Qwist, Erik Damgaard Christensen
Summary: This study focuses on addressing the unphysical velocity oscillations at the free surface in the two-phase solution procedure of OpenFOAM. The proposed method, named Direct Surface Description (DSD), imposes boundary conditions directly on the free surface to improve the accuracy of wave-induced load estimation. The implementation of the DSD method in OpenFOAM is validated and compared to existing solution methods, showing promising results in accurately predicting free surface kinematics and simulating complex and realistic cases.
COASTAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Ashkan Eftekhari, Emil Nielsen Holck, Jelmer Westra, Niels Thue Olsen, Niels Henrik Bruun, Lisette Okkels Jensen, Thomas Engstrom, Evald Hoj Christiansen
Summary: This study conducted a meta-analysis of the 5-year outcomes of iFR-guided and FFR-guided revascularization, revealing an increased all-cause mortality and major adverse cardiovascular events rate in the iFR group.
EUROPEAN HEART JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Wooyoung Jeon, Sunho Park, Gyu-Mok Jeon, Jong-Chun Park
Summary: In this paper, a rogue wave generated by wave energy focusing was simulated in a numerical wave tank. The study compared the characteristics of the generated rogue wave with a regular wave and investigated its effects on floating bodies.
APPLIED SCIENCES-BASEL
(2022)
Article
Computer Science, Interdisciplinary Applications
Alireza Asadbeygi, Simon Lee, John Kovalchin, Hoda Hatoum
Summary: This study investigated the impact of coronary artery aneurysm (CAA) shape indices on local hemodynamics using the response surface method (RSM) and validated the regression models. The results indicated that aneurysm diameter is the main determining factor in thrombotic risk, and cases with shorter length experienced flow stagnation.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Engineering, Biomedical
Nhien Tran-Nguyen, Francesca Condemi, Andrew Yan, Stephen Fremes, Piero Triverio, Laura Jimenez-Juan
Summary: This prospective study used computational fluid dynamics to investigate how graft hemodynamics may vary among different types of grafts one month after coronary artery bypass graft (CABG) surgery. The study found differences in abnormal wall shear stress area among different types of grafts, suggesting a possible influence on long-term graft failure rates.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Jannis Stader, Marios Antoniadis, Matti Ussat, Rolf Wachter, Daniel Lavall, Michael Metze, Martin Neef, Christian Spies, Ulrich Laufs, Karsten Lenk
Summary: This study compared the novel method of Quantitative Flow Ratio (QFR) with the established invasive measurements of coronary blood flow using Instantaneous Wave-free Ratio (iFR) or Resting Full-cycle Ratio (RFR) in daily cathlab routine. The results showed a significant correlation between QFR and iFR or RFR, with QFR measurement requiring less time and lower radiation dose.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher C. Y. Wong, Ashkan Javadzadegan, Cuneyt Ada, Jerrett K. Lau, Ravinay Bhindi, William F. Fearon, Leonard Kritharides, Martin K. C. Ng, Andy S. C. Yong
Summary: This study aimed to evaluate the relationship between wall shear stress (WSS), functionally significant epicardial coronary stenoses, and microcirculatory dysfunction. The results showed that fractional flow reserve and instantaneous wave-free ratio independently predicted the total burden of low WSS and maximum lesion WSS in coronary arteries, while microcirculatory dysfunction was not associated with WSS.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Engineering, Biomedical
Boyan Mao, Wenxin Wang, Zhou Zhao, Xi Zhao, Lanlan Li, Huixia Zhang, Youjun Liu
BIOMEDICAL ENGINEERING ONLINE
(2016)
Article
Engineering, Biomedical
Wenxin Wang, Boyan Mao, Haoran Wang, Xueying Geng, Xi Zhao, Huixia Zhang, Jinsheng Xie, Zhou Zhao, Bo Lian, Youjun Liu
BIOMEDICAL ENGINEERING ONLINE
(2016)
Article
Biophysics
Xi Zhao, Youjun Liu, Lanlan Li, Wenxin Wang, Jinsheng Xie, Zhou Zhao
JOURNAL OF BIOMECHANICS
(2016)
Article
Biophysics
Xi Zhao, Youjun Liu, Jinsheng Xie, Zhou Zhao, Aike Qiao
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2016)
Article
Biophysics
Mingzi Zhang, Yujie Li, Xi Zhao, David I. Verrelli, Winston Chong, Makoto Ohta, Yi Qian
JOURNAL OF BIOMECHANICS
(2017)
Article
Biophysics
Wenxin Wang, Youjun Liu, Xi Zhao, Jinsheng Xie, Aike Qiao
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2017)
Article
Biophysics
Lanlan Li, Youjun Liu, Xi Zhao, Boyan Mao, Huixia Zhang
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2017)
Article
Engineering, Multidisciplinary
Wenxin Wang, Dalin Tang, Boyan Mao, Bao Li, Xi Zhao, Jian Liu, Youjun Liu
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2018)
Article
Cardiac & Cardiovascular Systems
Chun Xiang Tang, Chun Yu Liu, Meng Jie Lu, U. Joseph Schoepf, Christian Tesche, Richard R. Bayer, H. Todd Hudson, Xiao Lei Zhang, Jian Hua Li, Yi Ning Wang, Chang Sheng Zhou, Jia Yin Zhang, Meng Meng Yu, Yang Hou, Min Wen Zheng, Bo Zhang, Dai Min Zhang, Yan Yi, Yuan Ren, Chen Wei Li, Xi Zhao, Guang Ming Lu, Xiu Hua Hu, Lei Xu, Long Jiang Zhang
JACC-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Mingzi Zhang, Jinlong Liu, Haibo Zhang, David I. Verrelli, Qian Wang, Liwei Hu, Yujie Li, Makoto Ohta, Jinfen Liu, Xi Zhao
Summary: This study validated two novel computational strategies, TVA and TVF, for estimating pressure gradients in patients with aortic coarctation. Compared to unrefined Doppler echocardiography, TVA showed stronger correlation, higher sensitivity, and specificity in identifying critical pressure drops.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Physiology
Bao Li, Ke Xu, Jincheng Liu, Boyan Mao, Na Li, Hao Sun, Zhe Zhang, Xi Zhao, Haisheng Yang, Liyuan Zhang, Tianming Du, Jianhang Du, Youjun Liu
Summary: Traditional EECP treatment for coronary heart disease patients focuses solely on blood pressure values, but long-term application leads to improved hemodynamic environment around coronary arteries. Studies have shown that increasing pressure amplitude and pressurization duration during counterpulsation can enhance coronary blood flow and reduce wall shear stress, with duration being the predominant factor.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Zhongzhi Jia, Junhao Mei, Wei Ding, Xi Zhao, Wen Gong, Haiyang Yu, Lihao Qin, Zeyu Piao, Wenhua Chen, Liming Tang
Summary: This study explored the role of hemodynamic factors in the occurrence of superior mesenteric artery dissection (SMAD) and identified histopathologic changes in the artery wall using a fluid-structure interaction simulation method. The results showed that increased aortomesenteric angle and SMA curvature were risk factors for SMAD, causing local hemodynamic abnormalities and histopathologic changes in the anterior wall of the SMA.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Bao Li, Tao Liu, Jincheng Liu, Youjun Liu, Boqiang Cao, Xi Zhao, Wenxin Wang, Mengchao Shi, Liyuan Zhang, Ke Xu, Mingyan Chen, Chuanqi Wen, Mingzi Zhang
Summary: This study compared the simulated haemodynamics of intracranial aneurysms using generic boundary conditions and flow conditions measured in vivo. The results showed that incorporating patient-specific boundary conditions is critical for accurately characterising aneurysmal haemodynamics using computational fluid dynamics (CFD), while different outflow strategies may not introduce significant uncertainties.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Xi Zhao, Linghsuan Meng, Xu Tong, Xiaotong Xu, Wenxin Wang, Zhongrong Miao, Dapeng Mo
Summary: This study aims to validate a novel computational strategy for determining the reference value of microcirculatory resistance in patients with cerebrovascular stenosis. Results show a strong correlation and agreement between the computational strategy and invasive pressure measurements as well as transcranial Doppler assessment.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
